1984
DOI: 10.1128/iai.46.3.710-714.1984
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Staphylococcus aureus peptidoglycan induces histamine release from basophil human leukocytes in vitro

Abstract: Whole killed cells, cell walls, and peptidoglycans of Staphylococcus aureus were found to release histamine from human leukocytes and isolated rat mast cells in vitro. The histamine-releasing capability increased in the order of whole bacteria, cell walls, and peptidoglycans. Peptidoglycan was found to release histamine by a nonimmunological mechanism, as demonstrated by release in cells deprived of surface immunoglobulins, whereas whole bacteria and cell walls seemed to operate both by immunological and nonim… Show more

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Cited by 36 publications
(12 citation statements)
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“…It is noteworthy that two organisms that frequently colonize the respiratory traet, H. infiuenzae and group A streptococci, induced little or no histamine release. The capsule bearing form of H. infiuenzae used in these experiments did not release histamine from human basophils [16]. However, the aeapsulated form, which, rather than the capsulated form, is found in asthma and chronic bronchitis, induces basophil histamine release by an IgE-dependent mechanism [10].…”
Section: Discussionmentioning
confidence: 79%
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“…It is noteworthy that two organisms that frequently colonize the respiratory traet, H. infiuenzae and group A streptococci, induced little or no histamine release. The capsule bearing form of H. infiuenzae used in these experiments did not release histamine from human basophils [16]. However, the aeapsulated form, which, rather than the capsulated form, is found in asthma and chronic bronchitis, induces basophil histamine release by an IgE-dependent mechanism [10].…”
Section: Discussionmentioning
confidence: 79%
“…The finding that peptidoglyean isolated from Staph. aureus failed to induce release from tonsillar mast cells indieates that the suggestion of peptidoglyean sugars being involved in bacteria-induced histamine release [16] might be of no significance in adenoidal cells.…”
Section: Discussionmentioning
confidence: 89%
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“…2% basophilocytes. The cells were obtained by Ficoll-Hypaque gradient centrifugation, washed twice, and suspended in a buffered (pH 7.4) solution of Tris-AMC (albumin, magnesium, calcium) (Espersen et al, 1984). The capability of microorganisms to trigger histamine release from the basophilocytes was examined by incubating the leukocytes for 40 min at 37°C with whole formalin-killed bacteria or their cell wall components (endotoxins, peptidoglycan), influenza A virus or fungal spores of moulds.…”
Section: Introductionmentioning
confidence: 99%