Staphylococcus aureus (MSSA) and MRSA (CC398) isolated from post-mortem samples from pigs

Wolf, P.J. van der; Rothkamp, Anja; Junker, K.; Neeling, Albert J. de

doi:10.1016/j.vetmic.2012.01.025

Cited by 23 publications

(19 citation statements)

References 11 publications

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“…Little information is available regarding pigs because Staphylococcus hyicus is the major pathogenic Staphylococcus species in these animals [47], although S. aureus has been isolated occasionally from lesions in pigs [47]. More recent reports, however, show that LA-MRSA CC398 may infect humans and pigs more often than previously thought [48][49][50], but this question needs further study.…”

Section: Cc398mentioning

confidence: 98%

Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Section: Cc398mentioning

confidence: 98%

Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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“…In addition most veterinary laboratories would assume any coagulase-positive staphylococci isolated from pigs were Staphylococcus hyicus and not investigate such isolates any further. However there are now reports of isolation of LA-MRSA from pathological lesions in pigs [66]. Apart from animal to animal spread which is a feature of this strain [67] one of the early features of LA-MRSA was its ready transfer from pigs to humans.…”

Section: Methicillin-resistant Staphylococcus Aureus (Mrsa)mentioning

confidence: 99%

Impact of antibiotic use in the swine industry

Barton

2014

Current Opinion in Microbiology

185

119

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Antibiotic resistance in bacteria associated with pigs not only affects pig production but also has an impact on human health through the transfer of resistant organisms and associated genes via the food chain. This can compromise treatment of human infections. In the past most attention was paid to glycopeptide and streptogramin resistance in enterococci, fluoroquinolone resistance in campylobacter and multi-drug resistance in Escherichia coli and salmonella. While these are still important the focus has shifted to ESBL producing organisms selected by the use of ceftiofur and cefquinome in pigs. In addition Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) suddenly emerged in 2007. We also need to consider multi-resistant strains of Streptococcus suis. Environmental contamination arising from piggery wastewater and spreading of manure slurry on pastures is also a growing problem.

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“…Despite the small number of isolates representative of the 1970's, this unique collection contained all the major biotypes described in pigs in the past [1], [2], [5], [35] and all the most common clonal lineages reported in pigs today except ST398 [15], [37], [38]. However, marked phenotypic and genotypic differences were observed between historical and contemporary isolates, indicating that the S. aureus population structure in pigs has undergone major changes over the last 40 years.…”

Section: Discussionmentioning

confidence: 99%

“…The two most common biotypes reported by Devriese in 1984 [2], biotype A (38/68 isolates) and the human ecovar (14/68 isolates), were represented in our historical collection (5/32 and 3/32 isolates, respectively) but were either rare (1/59 isolates belonging to biotype A) or absent (human ecovar) in our contemporary collection. A temporal reduction in the diversity of the porcine S. aureus population could be inferred on the basis of MLST since nine STs found among historical isolates could not be detected among contemporary isolates (Table 1), and are not currently associated with the pig host [15], [37], [38]. The temporal change in population structure was confirmed by spa typing since the spa types displayed by historical isolates are only occasionally reported in pigs today (t008, t012, t1236 and t526) [14], [15], [24], [38]–[40] or have only been reported in humans (t156 and t213) [41], [42].…”

Section: Discussionmentioning

confidence: 99%

Phenotypes and Genotypes of Old and Contemporary Porcine Strains Indicate a Temporal Change in the S. aureus Population Structure in Pigs

et al. 2014

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Introduction Staphylococcus aureus sequence type ST398 has recently gained attention due to the spread of methicillin-resistant strains among people exposed to livestock. The aim of this study was to explore temporal changes in the population structure of S. aureus in pigs over the last 40 years with particular reference to the occurrence of ST398.MethodsWe analysed a unique collection of 91 porcine strains isolated in six countries between 1973 and 2009 using a biotyping scheme described in the 1970's in combination with spa typing and multi-locus sequence typing (MLST). The collection comprised 32 historical isolates from 1973–1974 (n = 19) and from 1991–2003 (n = 13), and 59 contemporary isolates from 2004–2009. The latter isolates represented the most common MLST types (ST1, ST9, ST97 and ST433) and spa types isolated from pigs in Europe.Results and Discussion S. aureus sequence type ST398 was not found among old isolates from the 1970's or from 1991–2003, suggesting that this lineage was absent or present at low frequencies in pigs in the past. This hypothesis is supported by the observed association of ST398 with the ovine ecovar, which was not described in pigs by studies carried out in the 1970's. In addition, various phenotypic and genotypic differences were observed between old and contemporary isolates. Some biotypes commonly reported in pigs in the 1970's were either absent (human ecovar) or rare (biotype A) among contemporary isolates. Nine clonal lineages found among old porcine isolates are occasionally reported in pigs today (ST8, ST30, ST97, ST387, ST1092, ST2468) or have never been described in this animal host (ST12, ST133, ST1343). These results indicate that the population structure of porcine S. aureus has changed over the last 40 years and confirm the current theory that S. aureus ST398 does not originate from pigs.

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Staphylococcus aureus (MSSA) and MRSA (CC398) isolated from post-mortem samples from pigs

Cited by 23 publications

References 11 publications

Livestock-Associated MRSA and Its Current Evolution

Livestock-Associated MRSA and Its Current Evolution

Impact of antibiotic use in the swine industry

Phenotypes and Genotypes of Old and Contemporary Porcine Strains Indicate a Temporal Change in the S. aureus Population Structure in Pigs

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