Impact of antibiotic use in the swine industry

Barton, Mary

doi:10.1016/j.mib.2014.05.017

Cited by 185 publications

(138 citation statements)

References 81 publications

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“…Indeed, by the turn of the 20th century, the majority of antibiotic usage in the United States was for agricultural purposes. This approach has led to a dramatic increase in antibiotic resistance in several human pathogens that originate from domesticated animals, including Campylobacter species (392).…”

Section: Impact Of Antibiotic Usage In Animals On Campylobacter Resismentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

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SUMMARY Campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. The incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. The dramatic increase in North America, Europe, and Australia is alarming, and data from parts of Africa, Asia, and the Middle East indicate that campylobacteriosis is endemic in these areas, especially in children. In addition to C. jejuni , there is increasing recognition of the clinical importance of emerging Campylobacter species, including Campylobacter concisus and Campylobacter ureolyticus . Poultry is a major reservoir and source of transmission of campylobacteriosis to humans. Other risk factors include consumption of animal products and water, contact with animals, and international travel. Strategic implementation of multifaceted biocontrol measures to reduce the transmission of this group of pathogens is paramount for public health. Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come. This review provides a comprehensive overview of the global epidemiology, transmission, and clinical relevance of Campylobacter infection.

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Section: Impact Of Antibiotic Usage In Animals On Campylobacter Resismentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

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“…At present, resistance to almost all known antibiotics has emerged with the sequential introduction of new or improved antibiotics in clinical and agricultural settings (1, 2). Therefore, continued development of new or improved antibiotics is of great importance to human health.…”

Section: Introductionmentioning

confidence: 99%

The Lantibiotic NAI-107 Efficiently Rescues Drosophila melanogaster from Infection with Methicillin-Resistant Staphylococcus aureus USA300

Thomsen

Mojsoska

Cruz

et al. 2016

Antimicrob Agents Chemother

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We used the fruit fly Drosophila melanogaster as a cost-effective in vivo model to evaluate the efficacy of novel antibacterial peptides and peptoids for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. A panel of peptides with known antibacterial activity in vitro and/or in vivo was tested in Drosophila. Although most peptides and peptoids that were effective in vitro failed to rescue lethal effects of S. aureus infections in vivo, we found that two lantibiotics, nisin and NAI-107, rescued adult flies from fatal infections. Furthermore, NAI-107 rescued mortality of infection with the MRSA strain USA300 with an efficacy equivalent to that of vancomycin, a widely applied antibiotic for the treatment of serious MRSA infections. These results establish Drosophila as a useful model for in vivo drug evaluation of antibacterial peptides. Since the golden era of antibiotic drug development of the 1940s to 1960s, the development and spread of multidrug resistance (MDR) have become a huge burden to societies. At present, resistance to almost all known antibiotics has emerged with the sequential introduction of new or improved antibiotics in clinical and agricultural settings (1, 2). Therefore, continued development of new or improved antibiotics is of great importance to human health. However, new antibiotics are lacking, and few are under development for treatment of MDR infectious bacteria, as drug development is costly and success from in vitro discovery to application in clinical settings is limited.Bacterial infections with methicillin-resistant Staphylococcus aureus (MRSA) are no longer sporadic in their distribution and prevalence (3, 4). MRSA strains are associated with both community (CA-MRSA)-and hospital (HA-MRSA)-acquired infections, with the highly ␤-lactam-resistant CA-MRSA clone USA300 accounting for up to 80% of all MRSA infections in the United States (5). High-level ␤-lactam resistance is due to acquisition of staphylococcal cassette chromosome mec (SCCmec) elements, including the mecA gene, which encodes an alternative version of the penicillin binding protein (PBP2A) that is inducible (6, 7) and has a lowered affinity for ␤-lactam antibiotics (8). SCCmec elements are often associated with carriage of genes encoding products involved in resistance to other antibiotics, including aminoglycoside-modifying enzymes, such as acetyltransferase, adenylyltransferase, or phosphotransferase (9). Due to this resistance, MRSA treatment often includes glycopeptide antibiotics, such as vancomycin, or oxazolidinones, such as linezolid. However, failure of vancomycin treatment has been reported for vancomycin-intermediate S. aureus (VISA) (10) and vancomycin-resistant S. aureus (VRSA) (11) strains. On the other hand, linezolid resistance is rare (12) but has been observed in association with mutations in the rRNA gene encoding the 23S RNA or through carriage of a Cfr rRNA methyltransferase gene (13,14). Furthermore, resistance to the last-resort antibiotic daptomycin has been reported (15,16...

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“…It must be kept in mind that, at weaning, the liquid or/and semiliquid diet becomes dry food. Thus, the piglets are exposed to antibiotics used in the food as growth promotion in some countries (Barton, 2014).…”

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confidence: 99%

“…Moreover, antibiotics are used with therapeutic purposes, with medicated feeds being the most common mode of administration of the drug (Barton, 2014). Antibacterial growth promoters belonging to different groups of antibiotics structurally unrelated exert their antibacterial activity by several mechanisms.…”

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confidence: 99%