Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis

Zele, Thibaut Van; Gevaert, Philippe; Watelet, Jean-Baptiste; Claeys, Geert; Holtappels, Gabriële; Claeys, C; Cauwenberge, Paul Van; Bachert, Claus

doi:10.1016/j.jaci.2004.07.013

Cited by 375 publications

(363 citation statements)

References 5 publications

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“…[38][39][40][41][42][43][44] In eosinophilic disease, these bacteria commonly include Staphylococcus spp. 8,45 These bacteria can drive the recurrent acute infections that plague CS patients, when they transform into their planktonic state and emerge from the biofilm. However, even in their indolent biofilm-associated state, these bacteria are not innocuous and can be a robust source of superantigens, [45][46][47][48][49] immune adjuvants, and of allergenic (IgE inducing) proteins (Fig.…”

Section: Sensitization To Colonizing Pathogens Bacteriamentioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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Section: Sensitization To Colonizing Pathogens Bacteriamentioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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“…The pathogenesis of NP involves nasal polyp fibroblasts through synthetizing IL-6 to modulate the activation of immune responses (plasma cell formation) and synthesis of stroma [21,23]. Van Zele et al [24] showed increased colonization of NP by Staphylococcus aureus and presence of specific IgE directed against Staphylococcus aureus exotoxins in NP tissue. Rates of colonization and IgE presence in NP tissue was increased in subjects with NP and co-morbid asthma [24].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Cytokine Levels in Nasal Fluid and Scored Clinical Parameters in Patients with Nasal Polyposis

Perić

Vojvodić

Radulović

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this study was to compare the cytokine levels in nasal fluid in subjects with nasal polyposis (NP) and co-morbid asthma and NP patients without asthma and to correlate these levels with clinical parameters of severity of disease. Forty NP patients (20 asthmatic and 20 nonasthmatic) were enrolled. Nasal secretion samples were collected from nasal cavities of all 40 subjects. The levels of Th1 cytokines IL-2, IL-12 and IFN-c, Th2 cytokines IL-4, IL-5, IL-6, and IL-10, chemokine IL-8, and proinflammatory cytokines IL-1b, TNF-a and TNF-b were measured using flow cytometric method. Each of the 40 patients was staged clinically according to global nasal symptom score, endoscopic score, and Lund-Mackay computed tomography (CT) score. The concentrations of Th2 cytokines IL-5, IL-6 and IL-10 were significantly higher (P \ 0.01, P \ 0.01, P \ 0.05) in patients with NP and asthma compared with NP patients without asthma.Positive correlations were observed between concentration of IL-2 in nasal secretions and global nasal symptom score, endoscopic score, and Lund-Mackay score only in NP patients without asthma. We also found positive correlation between CT score and the levels of IL-8, IL-4, and IL-1b in nonasthmatic patients. Finally, our results showed a positive correlation between IL-5 levels in nasal fluid and endoscopic score only in asthmatic patients. NP in asthmatic patients have different immunological patterns compared to those without asthma. We also concluded that concentrations of cytokines measured in nasal fluid were not sensitive enough to determine the severity of disease.

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“…Additionally, patients with abundant expression of Corynebacterium tuberculostearicum at the time of endoscopic surgery had an optimal outcome, while patients with high S. aureus had a suboptimal outcome (35). Coherently, an increase in nasal S. aureus carriage and the presence of S. aureus enterotoxin-specific IgE antibodies have been described in the mucosa of CRSwNP subjects and perennial allergic rhinitis patients (33,37), and this is even higher in CRSwNP patients with asthma comorbidity and aspirin sensitivity. The further analysis on antibiotic-resistant bacteria in allergic rhinitis highlighted that an increase in methicillin-resistant Staphylococcus aureus burden provides an insight into the difficulty of eradicating the bacterium (38).…”

Section: The Prevalence Of Bacteria In the Airwaysmentioning

confidence: 99%

“…Clearly, neonatal colonization with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumonia had a strong correlation with the subsequent recurrent wheeze and childhood asthma (6,29,30). Evidence was also available that S. aureus acted as a risk factor for asthma development in children and young adults, but not in older adults (31)(32)(33). It is evident that bacterial organisms act as important contributors to asthma exacerbations.…”

Section: The Prevalence Of Bacteria In the Airwaysmentioning

confidence: 99%

Viruses and bacteria in Th2‐biased allergic airway disease

Feng

Zhang

Gevaert

et al. 2016

Allergy

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Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.

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Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis

Cited by 375 publications

References 5 publications

Chronic sinusitis pathophysiology: The role of allergy

Chronic sinusitis pathophysiology: The role of allergy

Correlation Between Cytokine Levels in Nasal Fluid and Scored Clinical Parameters in Patients with Nasal Polyposis

Viruses and bacteria in Th2‐biased allergic airway disease

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