Staphylococcal Infections

Evaluation and Treatment of Community-Acquired Staphylococcus aureus Infections in Term and Late-Preterm Previously Healthy Neonates

“…1,8 We recommend admitting all neonates with infections that are more severe than pustulosis and those who receive any evaluation for bacterial infection of the blood, urine, or CSF. Empiric antibiotics should be based on the local susceptibility pattern of CA S aureus isolates; clindamycin with or without gentamicin for patients with noninvasive disease and vancomycin, nafcillin, and gentamicin for patients with invasive infections are commonly used in our setting, where Ͻ10% of CA S aureus isolates are resistant to clindamycin.…”

“…CA organisms were isolated (1) within 48 hours of hospitalization; (2) during an outpatient visit; or (3) after 48 hours of hospitalization but clinical evidence suggested a CA infection, such as symptoms present at hospital admission. Exclusion criteria were (1) underlying illness predisposing to frequent hospitalizations or medical visits, (2) indwelling catheters or percutaneous medical devices, and (3) hospitalization within the past year excluding birth. 9 The Infectious Disease Research Laboratory coded and froze the S aureus specimens in horse blood at Ϫ80°C.…”

“…1 Communityacquired (CA) methicillin-resistant S aureus (MRSA) isolates have been documented in nosocomially transmitted infections in the NICU as have CA infections in previously healthy neonates at Texas Children's Hospital (TCH). 2,3 Postpartum women in endemic areas are also at risk for S aureus skin infections, including mastitis, and cesarean incision infections after an uncomplicated pregnancy and delivery.…”

“…[3][4][5][6][7][8] Treatment recommendations for CA S aureus disease in previously healthy neonates are limited. 1,8 For example, there are no clear guidelines regarding the decision to use local versus systemic antibiotics or oral versus parenteral therapy; empiric antibiotic selection; duration of therapy; inpatient versus outpatient treatment; and the indications for an evaluation for a serious bacterial infection (SBI) obtaining blood, urine, and cerebrospinal fluid (CSF) for culture.…”

Change of specific T cells in an emerging neonatal infectious disease induced by a bacterial superantigen

“…Although the new neonatal disease and TSS appeared to have the same cause, clinical symptoms of the new disease did not match the clinical criteria for TSS. We concluded that the disease was a special form of TSS and designated it NTED (10, 12).…”