Staphylococcal Exotoxins and Nasal Polyposis: Analysis of Systemic and Local Responses

Tripathi, Anju; Kern, Robert C.; Conley, David B.; Seiberling, Kristin; Klemens, Julie Chiang; Harris, Kathleen E.; Suh, Lydia; Huang, Jie; Grammer, Leslie C.

doi:10.1177/194589240501900401

Cited by 65 publications

(63 citation statements)

References 37 publications

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“…903 Serum SEA-specific, SEB-specific, and toxic shock syndrome toxin 1 (TSST-1)-specific IgE antibodies were detected in 0% vs 75% of healthy controls vs CRSwNP, respectively, and in about 60% of CRSwNP evidence of superantigen effects on the T cell receptor V-beta expansion in both CD4+ and CD8+ lymphocytes was noted. 904 The expansion of lymphocytes expressing T cell receptors with specific V beta-domains was limited to the polyp tissue, whereas much less bias was found in the blood. 905 The findings of superantigens in CRSwNP were independently confirmed by others, 906,907 and the association of those findings with an eosinophilic inflammation was also reported by multiple groups.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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548

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

548

888

View full text Add to dashboard Cite

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“…Flow cytometry also enabled T-cell repertoire analysis in tissues and organs. Expansions of several Vb families have been usually demonstrated in cases of autoimmune injury (18), infection (32,33), or tumor involvement (3,4,8,9,24,34), indicative of the presence of specific immune cells in pathologic lesions (18,35). In lymph nodes, such studies are rare, and have been only performed on small groups of patients with limited numbers of anti-Vb mAbs (23,34,(36)(37)(38).…”

Section: (Cdr3)mentioning

confidence: 99%

Efficient characterization of the TCR repertoire in lymph nodes by flow cytometry

et al. 2009

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Analysis of the T-cell receptor (TCR) repertoire by flow cytometry proved to be relevant for investigating T-cell diversity and detecting reactive cells in blood samples. We used this approach to characterize non-malignant T-lymphocytes in lymph nodes and give insights into their origin. The TCR repertoire of CD41 and CD81 T-cells from 81 lymph nodes was analyzed with a four-color flow cytometer using a wide panel of 25 anti-Vb monoclonal antibodies. Flow cytometry proved to be a useful and informative technique. We demonstrated a diversified TCR-Vb repertoire, and only low level expansions, in 53% of the samples. They involved nearly all Vb families, were more frequent in the CD81 subset of older patients, but were not related to pathology. No evidence could be demonstrated in favor of stimulation by common antigens. Interestingly, the TCR-Vb repertoire proved to be very similar in lymph nodes and blood samples. Our results argue that in the cases studied, lymph node enlargement is mainly due to an increased homing of circulating T-cells. They also provide reference values for expression of 25 TCR-Vb in lymph nodes, which could serve as a basis for further applications in diagnosis of T-cell lymphoproliferative disorders. ' 2009 International Society for Advancement of Cytometry

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“…8,45 These bacteria can drive the recurrent acute infections that plague CS patients, when they transform into their planktonic state and emerge from the biofilm. However, even in their indolent biofilm-associated state, these bacteria are not innocuous and can be a robust source of superantigens, [45][46][47][48][49] immune adjuvants, and of allergenic (IgE inducing) proteins (Fig. 2).…”

Section: Sensitization To Colonizing Pathogens Bacteriamentioning

confidence: 99%