Staphylococcal enterotoxin B administration in pregnant rats alters the splenic lymphocyte response in adult offspring rats

Zhou, Ping; Zhang, Xinsheng; Xu, Zhizhan; Gao, Shanjun; Zheng, Qingwei; Xu, Mingzhu; Shen, Lin; Feng, Yu; Guan, Jing

doi:10.1186/s12866-016-0921-2

Cited by 95 publications

(84 citation statements)

References 23 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the MLVA-16 results obtained did not match those obtained by phylogeny based on WGS. This difference may be explained by the higher resolution power provided by WGS and homoplasy of B. abortus VNTR markers, as previously proposed [55][56][57][58].…”

Section: Discussionmentioning

confidence: 86%

Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis

et al. 2020

View full text Add to dashboard Cite

Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean and the Middle East. Epidemiological strategies combined with phylogenetic methods provide the high-resolution power needed to study relationships between surveillance data and pathogen population dynamics, using genetic diversity and spatiotemporal distributions. This information is crucial for prevention and control of disease spreading at a local and worldwide level. In Costa Rica (CR), the disease was first reported at the beginning of the 20 th century and has not been controlled despite many efforts. We characterized 188 B. abortus isolates from CR recovered from cattle, humans and water buffalo, from 2003 to 2018, and whole genome sequencing (WGS) was performed in 95 of them. They were also assessed based on geographic origin, date of introduction, and phylogenetic associations in a worldwide and national context. Our results show circulation of five B. abortus lineages (I to V) in CR, phylogenetically related to isolates from the United States, United Kingdom, and South America. Lineage I was dominant and probably introduced at the end of the 19 th century. Lineage II, represented by a single isolate from a water buffalo, clustered with a Colombian sample, and was likely introduced after 1845. Lineages III and IV were likely introduced during the early 2000s. Fourteen isolates from humans were found within the same lineage (lineage I) regardless of their geographic origin within the country. The main CR lineages, introduced more than 100 years ago, are widely spread throughout the country, in contrast to new introductions that seemed to be more geographically restricted. Following the brucellosis prevalence and the farming practices of several middle-and low-income countries, similar scenarios could be found in other regions worldwide.

show abstract

Section: Discussionmentioning

confidence: 86%

Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The WGS analysis supported this continental segregation [ 117 ]. However, comparisons of different bacteria from smaller geographic areas by WGS and MLVA are not always straightforward, as it will be further discussed [ 26 , 117 , 118 , 119 , 120 ].…”

Section: Brucella Host Distribution From Differmentioning

confidence: 99%

“…The use of MLVA has proved useful for tracking Brucella outbreaks or infection sources to study the molecular epidemiology of Brucella in specific countries [ 129 , 130 , 131 , 132 ] and in a worldwide context [ 98 ]. Despite its usefulness, the homoplasy in VNTR markers in some Brucella species, as B. abortus and B. ovis , lowers the levels of discrimination and resolution of cladograms as compared to WGS phylogenetic analysis [ 26 , 117 , 120 ]. To reduce homoplasy and to understand phylogenetic relationships deeper, a systematic approach in Brucella MLVA, is to use the most stable VNTRs or provide further weight to the markers [ 133 ].…”

Section: Brucella Speciation and Host Preferencmentioning

confidence: 99%

See 1 more Smart Citation

Brucella Genomics: Macro and Micro Evolution

Suárez-Esquivel

Chaves-Olarte

Moreno

et al. 2020

IJMS

View full text Add to dashboard Cite

Brucella organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae is that the various species show a ~97% similarity at the genome level. Still, the distinct Brucella species display different host preferences, zoonotic risk, and virulence. After 133 years of research, there are many aspects of the Brucella biology that remain poorly understood, such as host adaptation and virulence mechanisms. A strategy to understand these characteristics focuses on the relationship between the genomic diversity and host preference of the various Brucella species. Pseudogenization, genome reduction, single nucleotide polymorphism variation, number of tandem repeats, and mobile genetic elements are unveiled markers for host adaptation and virulence. Understanding the mechanisms of genome variability in the Brucella genus is relevant to comprehend the emergence of pathogens.

show abstract

“…PRP transfer between closely related enterococcal species is unsurprising, and many cases of transfer between E. faecalis and E. faecium have been reported [27,68]. However, in liquid matings, higher rates of PRP transfer from E. faecalis to E. faecium are observed rather than vice versa [69,70].…”

Section: Inter-and Intraspecies Dissemination Of Prpmentioning

confidence: 99%

Competent but complex communication: The phenomena of pheromone-responsive plasmids

et al. 2020

View full text Add to dashboard Cite

Enterococci are robust gram-positive bacteria that are found in a variety of surroundings and that cause a significant number of healthcare-associated infections. The genus possesses a high-efficiency pheromone-responsive plasmid (PRP) transfer system for genetic exchange that allows antimicrobial-resistance determinants to spread within bacterial populations. The pCF10 plasmid system is the best characterised, and although other PRP systems are structurally similar, they lack exact functional homologues of pCF10-encoded genes. In this review, we provide an overview of the enterococcal PRP systems, incorporating functional details for the less-well-defined systems. We catalogue the virulence-associated elements of the PRPs that have been identified to date, and we argue that this reinforces the requirement for elucidation of the less studied systems.

show abstract

Staphylococcal enterotoxin B administration in pregnant rats alters the splenic lymphocyte response in adult offspring rats

Cited by 95 publications

References 23 publications

Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis

Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis

Brucella Genomics: Macro and Micro Evolution

Competent but complex communication: The phenomena of pheromone-responsive plasmids

Contact Info

Product

Resources

About