Stanley Mason: His contribution to the science of Biorheology

Goldsmith, Harry L.

doi:10.3233/bir-1989-26202

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Computer simulation solving Navier–Stokes equations coupled with FSI provided similar hematocrit-dependent increases in the rate of platelet adhesion. Our biological and computer simulation experiments support the central migration of erythrocytes in flowing blood established by Fahraeus in the early 20th century 28 29 in a parallel plate flow chamber. The potential importance of near-wall access of platelets in the presence of erythrocytes was suggested by the biological and simulation experiments in this study.…”

Section: Discussionsupporting

confidence: 71%

Important Regulatory Roles of Erythrocytes in Platelet Adhesion to the von Willebrand Factor on the Wall under Blood Flow Conditions

et al. 2021

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The roles of erythrocytes on platelet adhesion to von Willebrand factor (VWF) on the vessel wall through their membrane glycoprotein (GP)Ibα under blood flow condition is still to be elucidated. Blood specimens containing fluorescently labeled platelet and native, biochemically fixed, or artificial erythrocytes, at various hematocrits were perfused on a surface of VWF immobilized on the wall at a shear rate of 1,500 s-1. Rates of platelet adhesions were measured in each condition. Computer simulation of platelet adhesion to the VWF on the wall at the same shear rate was conducted by solving governing equations with a finite-difference method on K-computer. The rates of platelet adhesion were calculated at various hematocrits conditions in the computational domain of 100 µm (x-axis) x 400 µm (y-axis) x 100 µm (z-axis). Biological experiments demonstrated the positive correlation between the rates of platelet adhesion and hematocrit values in native, fixed, and artificial erythrocytes. (r=0.992, 0.934, and 0.825 respectively, p<0.05 for all). The computer simulation results supported the hematocrit dependent increase in platelet adhesion rates on VWF (94.3/sec at 10%, 185.2/sec at 20%, and 327.9/sec at 30%, respectively). These results suggest the important contributing role of erythrocytes on platelet adhesion to the VWF. The augmented z-axis fluctuation of flowing platelet caused by the physical presence of erythrocytes is speculated as the cause for hematocrit dependent increase in platelet adhesion.

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Section: Discussionsupporting

confidence: 71%

Important Regulatory Roles of Erythrocytes in Platelet Adhesion to the von Willebrand Factor on the Wall under Blood Flow Conditions

et al. 2021

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“…It suggests the importance of the near-wall access of platelets by central migration of erythrocytes in owing blood which was established by Fahraeus R in early 20 th century. 32,33 The most important biological role of erythrocytes is to transport oxygen from lung to peripheral organ.…”

Section: Discussionmentioning

confidence: 99%

Important Physical Regulatory Roles of Erythrocytes on Platelet Adhesion Under Blood Flow Conditions.

Tamura¹,

Shimizu²,

Shiozaki³

et al. 2021

Preprint

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Aim: Functional roles of erythrocytes on platelet adhesion to vessel wall under blood flow condition is still to be elucidated. Methods: Blood specimens containing native, biochemically fixed, or artificial erythrocytes, at various hematocrits were perfused on immobilized von Willebrand factor (VWF) at a shear rate of 1,500 s− 1. Number of platelets adhered on VWF within the region of interest (ROI: 5x103 µm2) was serially measured for 2 minutes using the fluorescent microscopy system. Regression analyses were conducted to evaluate the relationship between the rates of platelet adhesion and the hematocrit values. Computer simulation of platelet adhesion on the wall of von Willebrand factor (VWF) at a shear rate of 1,500 s− 1 was conducted by solving governing equations with a finite-difference method on K-computer. Calculations were conducted at various hematocrits conditions in the computational domain of 100 µm (x-axis) x 400 µm (y-axis) x 100 µm (z-axis). Results: Biological experiments demonstrated the positive correlations between the rates of platelet adhesion and hematocrit values in native, fixed, and artificial erythrocytes. (r = 0.992, 0.934, and 0.825, p < 0.05 for all) The number of platelets adhered after 2 minutes blood perfusion at 24% hematocrit of 221.7 ± 22.6/5x103 µm2 (fixed erythrocytes) and 208.0 ± 26.5/5x103 µm2(artificial ones), respectively, were comparable to that with native ones of 195.9 ± 28.3/5x103 µm2. The simulation results demonstrated the hematocrit dependent increase in platelet adhesion rates (94.3/sec at 10%, 185.2/sec at 20%, and 327.9/sec at 30%, respectively) suggesting the importance of augmented z-axis fluctuation of flowing platelet by erythrocytes as the cause of platelet adhesion. Conclusions: Our experimental results indicate the importance of the physical roles of erythrocytes inducing wall-normal fluctuations of flowing platelets on their vessel adhesion under blood flow conditions.

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S. G. Mason—A retrospective

Ven

1990

International Journal of Multiphase Flow

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Stanley Mason: His contribution to the science of Biorheology

Cited by 3 publications

References 30 publications

Important Regulatory Roles of Erythrocytes in Platelet Adhesion to the von Willebrand Factor on the Wall under Blood Flow Conditions

Important Regulatory Roles of Erythrocytes in Platelet Adhesion to the von Willebrand Factor on the Wall under Blood Flow Conditions

Important Physical Regulatory Roles of Erythrocytes on Platelet Adhesion Under Blood Flow Conditions.

S. G. Mason—A retrospective

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