Standardized mortality in eating disorders—a quantitative summary of previously published and new evidence

Nielsen, Søren R.K.; Møller-Madsen, S.; Isager, Torben; Jørgensen, Jan; Pagsberg, Anne Katrine; Theander, Sten

doi:10.1016/s0022-3999(97)00267-5

Cited by 148 publications

(76 citation statements)

References 27 publications

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“…Even though an adaptive role by 5-HTT locus, meiotic drive, population drift, or a bottleneck effect due to the reported increased mortality in AN, 7 could be invoked to explain this observation, at present (and given our sample size) all these hypotheses appear largely speculative. Nevertheless, we cannot exclude that deviation from H-W is related to an etiopathogenetic effect of the 5-HTTLPR in BN.…”

Section: Molecular Psychiatrymentioning

confidence: 87%

Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa

et al. 2000

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Section: Molecular Psychiatrymentioning

confidence: 87%

Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa

et al. 2000

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“…It varies widely in severity, but is usually associated with considerable disruption, suffering and morbidity, both psychiatric and physical. Furthermore, it has one of the highest mortalities of any functional psychiatric disorder (Neilsen et al, 1998). It is often difficult to manage within general services and new specialist services are being created throughout the country (Palmer & Treasure, 1999).…”

Section: Discussionmentioning

confidence: 99%

Anorexia nervosa: service consumption and outcome of local patients in the Leicester service

Palmer¹,

Gatward²,

Black³

et al. 2000

Psychiatr. bull.

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Aims and MethodA retrospective case note study provided data on the service consumption and outcome of treatment for a cohort of adult anorexia nervosa sufferers treated in a specialised secondary service.ResultsA cohort of 106 patients was studied. Only just over a quarter were ever admitted. Of a subset of 78 patients, first seen before 1994, nearly one-fifth failed to engage in treatment. Those who were admitted spent on average a total of 10 months in hospital, were in touch for four years and had over 100 therapy sessions. The majority who were treated solely as out-patients remained in touch with the service on average for over two years.Clinical ImplicationsServices for anorexia nervosa sufferers need to plan for prolonged contact with their patients and high rates of service consumption.

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“…The available literature, in particular recent reviews (Sullivan, 1995;Nielsen, 2001), quote an unusually high mortality rate (5-6%) after a 10-year follow-up, for a young, mainly female population that is affected by major eating disorders, and mostly due to suicide, alcohol abuse or medical complications of marasmic malnutrition (Sullivan, 1995;Nielsen et al, 1998;Emborg, 1999;Herzog et al, 2000;Keel et al, 2003). Finally, some recent papers have cast some doubts on the severity of this pathological condition, and claimed a reduction in the mortality rate in the last decades (Wentz et al, 2001;Korndorfer et al, 2003), even suggesting a protective action of malnutrition, owing to eating disorders, on cardiovascular mortality (Korndorfer et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Long-term mortality in anorexia nervosa: a report after an 8-year follow-up and a review of the most recent literature

Signorini¹,

Filippo²,

Panico³

et al. 2006

Eur J Clin Nutr

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Objective: To evaluate long-term mortality rate of anorexia nervosa (AN) patients in a southern Italy population compared to the most recent literature. Design: Retrospective and review setting. Patients and interventions: One hundred and forty-seven female AN patients, consecutively admitted from 1994 to 1997 to the Outpatient Unit, were re-examined between June and November 2003. Our data are compared with 10 other studies published since 1988. Results: One hundred and twenty-three deaths in 2240 patients, amounting to a total mortality rate of 5.25% were reported in the literature. Deaths due to suicide, AN-related and AN-unrelated diseases were 1.20, 3.07 and 0.98%, respectively. After correcting for unrelated deaths, mortality rate was 4.27%. In our 8-year follow-up, we found a mortality rate of 2.72% (1.82% after correcting for unrelated deaths). Standardized mortality ratio was 9.7. Conclusion: We interpret our favourable findings as a consequence of an integrated, clinical-nutritional and psychiatric approach. Finally, considering AN demographic characteristics, that is young female subjects in Westernized societies, mortality rate is confirmed to be dramatically high. Sponsorship: 'Federico II' University of Naples.

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Standardized mortality in eating disorders—a quantitative summary of previously published and new evidence

Cited by 148 publications

References 27 publications

Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa

Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa

Anorexia nervosa: service consumption and outcome of local patients in the Leicester service

Long-term mortality in anorexia nervosa: a report after an 8-year follow-up and a review of the most recent literature

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