Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa

Investigation of Epistasis Between the Serotonin Transporter and Norepinephrine Transporter Genes in Anorexia Nervosa

“…Interestingly, AN patients have similar S allele frequencies across both the current and case-control studies: 0.48-0.51 (w 2 ¼ 0.60, df ¼ 3, p ¼ 0.895). We also found no association between the S allele and AN-BP reported by Di Bella et al (2000), although our 16 AN-BP trios provide low power for this observation. Additionally we found no association between 5-HTTLPR and AN females, AN subtype, age at onset, or minimum BMI.…”

“…We also did not observe the increased S allele frequency seen in case-control study AN patients possibly due to clinical and/or genetic heterogeneity, variability of linkage disequilibrium between the 5-HTTLPR and another susceptibility allele in different samples, or population stratification affecting the case-control findings. Supporting population stratification, S allele frequencies in case-control study controls (Di Bella et al, 2000;Sundaramurthy et al, 2000;Fumeron et al, 2001) and in the nontransmitted alleles reported here range from 0.36 to 0.49 (w 2 ¼ 9.48, df ¼ 3, p ¼ 0.024) and S allele frequencies range from 0.11 to 0.70, worldwide (Gelernter et al, 1999). We used the TDT to diminish problems due to population stratification.…”

“…Rare variants include a 15-repeat allele (Nakamura et al, 2000) with undetermined effect on transcription. Case-control studies (Di Bella et al, 2000;Sundaramurthy et al, 2000;Fumeron et al, 2001) demonstrate a trend towards increased frequency of the S allele, and S/S or S/L genotypes in AN patients, reaching statistical significance for AN-BP patients once (Di Bella et al, 2000) (p ¼ 0.020, odds ratio 1.9, 95% CI 1.1À3.1). However, the one family-based study (Hinney et al, 1997), which used the transmission disequilibrium test (TDT) (Spielman et al, 1993) and 55 trios (AN child+ parents), provided no evidence for preferential transmission of the S allele as 52 S/L parents transmitted 27 S and 25 L alleles to AN children (p ¼ 0.90).…”

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

“…Studies on the use of serotonin reuptake inhibitors (SSRIs) in malnourished AN patients showed no benefits of treatment (Kaye et al 1998); however, SSRIs seem to be effective in preventing relapse in recovered AN patients (Kaye et al 2001). Genetic association studies showed possible implications of polymorphisms in the 5-HT 2A receptor, 5-HT 2C receptor, and serotonin transporter in AN (Collier et al 1997;Di Bella et al 2000;Hu et al 2003;Nacmias et al 1999;Westberg et al 2002), although other studies could not confirm these findings (Ando et al 2001;Gorwood et al 2002;Hinney et al 1997;Nishiguchi et al 2001).…”

Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake

“…[8][9][10] Our result might be a false positive because the AN sample is small. Nevertheless, in the more recent studies, 8,9 an excess of S allele was found in AN although this was not statistically significant. The discrepancy with Hinney et al 10 could be due to a different selection of patients.…”