StandardizedOlea europaeaL. leaf extract exhibits protective activity in carbon tetrachloride-induced acute liver injury in rats: the insight into potential mechanisms

Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

“…The reduced concentrations of these markers as a result of olive leaf extract administration observed during the present study might be due to the presence of bioactive compounds such as phenolic and triterpenoid compounds; although, there is a difference observed between fresh and dried leaf extracts ( Table 1 ). As in the present study, previous research works on olive leaf extracts showed that CCl 4 caused significant elevation of ALT, AST, ALP activities, while pretreatment with olive leaf extracts significantly suppresses the increase in their levels [ 24 , 25 ]. It has been reported that effective hepatoprotective agents must suppress the increase in ALT activity and bring it closer to a normal level in order to induce liver-healing.…”

“…Our results are in agreement with those reported in the literature. In fact, when investigating the protective activity of dried olive leaf extract on CCl 4 -induced liver damage in rats, the researchers reported that the concentration of MDA significantly increased in rats administered CCl 4 when compared to the control group [ 25 ]. A similar observation for increasing MDA levels was reported in another study [ 24 ] after which a significant decrease was registered in pretreated rats with (methanolic or butanolic) olive leaf extracts in comparison to CCl 4 -treated rats.…”

“…Oleuropein and hydroxytyrosol, as major compounds of olive leaves, have been reported to exert numerous pharmacological properties, including anticancer, antidiabetic, and anti-inflammatory activities [ 14 ]. Recently, the hepatoprotective activity of olive leaves against damage induced by CCl 4 [ 24 , 25 ], cadmium [ 26 , 27 ], paracetamol [ 28 ], thioacetamide [ 29 ], ethanol [ 5 ], fluoxetine [ 30 ] and deltamethrin [ 31 ] has receieved increasing interest in animal experiemts. However, available data about the hepatoprotective effect of olive leaf extracts or their major constituents are still scarce.…”

“…Hence, there is not enough literature about the hepatoprotective effect of olive leaves against CCl 4- induced damage. The existing published articles focused on methanolic or butanolic extracts of dried olive leaves obtained by Soxhlet apparatus [ 24 ] and ethanolic extract from dried olive leaves standardized to 16–24% of oleuropein [ 25 ]. As far we know, this is the first study on the hepatoprotective effect of Tunisian olive leaves on CCl 4 -induced toxicity.…”

Phenolic and Antioxidant Analysis of Olive Leaves Extracts (Olea europaea L.) Obtained by High Voltage Electrical Discharges (HVED)

“…Consequently, OLE as an antioxidant may reduce the risks for harmful health effects [3,10,11]. Also, recent studies on OLE confirmed potential coadjuvant use for cervical cancer treatments [12], inhibitory effects on the obesity [13], suppression of inflammatory cytokine production and the activation of NLRP3 inflammasomes in human placenta [14], potential as preventive therapy for neurodegenerative diseases [15], protective quality of testis and sperms [16], protection against intoxication of liver by carbon tetrachloride, kidney by cadmium, and brain by lead poisoning [17,18,19].…”