Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

Taamalli, Amani; Feriani, Anouar; Lozano‐Sánchez, Jesús; Ghazouani, Lakhdar; Mufti, Afoua; Allagui, Mohamed Salah; Segura‐Carretero, Antonio; Mhamdi, Ridha; Arráez‐Román, David

doi:10.3390/foods9060804

Cited by 25 publications

(18 citation statements)

References 50 publications

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“…In this sense, olive leaf composition has been studied by different authors [13][14][15][16][17], reporting the richness in bioactive compounds belonging to phenolic compounds, such as hydroxytyrosol, catechin, rutin, verbascoside, luteolin and oleuropein [18]. These compounds have been associated with antioxidant, anti-inflammatory, antiobesity or chemopreventive effects [15,[19][20][21][22][23][24], among other activities. Specifically, oleuropein, which is formed by elenolic acid, glucose and hydroxytyrosol, acts as a powerful antioxidant at skin level [2].…”

Section: Introductionmentioning

confidence: 99%

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

et al. 2021

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Olea europaea cultivar, native in the Mediterranean basin, has expanded worldwide, mainly due to the olive oil industry. This expansion is attributed to the benefits of olive oil consumption, since this product is rich in nutritional and bioactive compounds. However, the olive industry generates high amounts of wastes, which could be related to polluting effects on soil and water. To minimize the environmental impact, different strategies of revalorization have been proposed. In this sense, the aim of this work was to develop high cosmetic value added oleuropein-enriched extracts (O20 and O30), a bioactive compound from olive byproducts, performing a comprehensive characterization using high performance liquid chromatography coupled to mass spectrometry and evaluate their bioactivity by in vitro assays. A total of 49 compounds were detected, with oleuropein and its derivatives widely found in O30 extract, whereas iridoids were mainly detected in O20 extract. Moreover, 10 compounds were detected for the first time in olive leaves. Both extracts demonstrated strong antioxidant and antiradical activities, although O30 showed higher values. In addition, radical oxygen and nitrogen species scavenging and enzyme inhibition values were higher in O30, with the exception of HOCl and hyaluronidase inhibition assays. Regarding cell viability, olive byproduct extracts did not lead to a decrease in keratinocytes viability until 100 µg/mL. All data reported by the present study reflect the potential of industrial byproducts as cosmetic ingredients.

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Section: Introductionmentioning

confidence: 99%

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

et al. 2021

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“…Carbon tetrachloride (CCl 4 ) is a well-known hepatotoxin and potent industrial solvent widely used in laboratory to induce liver injury in animals (5). CCl 4 itself has no cytotoxic effect, but its rapid biotransformation to trichloromethyl and Cl − radicals with reacting oxygen catalyzed by cytochrome P450 in microsomes induced hepatotoxicity (6,7). It has been proved that several manifestations of liver damage are associated with oxidative stress and redox imbalance.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Pandit

Kumar

Kaur

et al. 2021

Environ Sci Pollut Res

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The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole and it is a principal aromatic component of star anise possessed several therapeutic properties. Results showed that CCl 4 treatment elevated the levels of different serum markers like serum glutamate oxaloacetate transaminase (SGOT) by 4.74 fold, serum glutamate pyruvate transaminase (SGPT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold and total bilirubin by 2.38 fold in contrast with control. It was observed that decreased levels of various liver antioxidant enzymes viz. CAT, GR, and GSH were signi cantly ameliorated by the pre-administration of rats with different doses (40, 80, and 160 mg kg -1 bw) of trans-Anethole. Furthermore, pre-treatment of trans-Anethole reduced phase I enzymes level, whereas elevated level of phase II detoxifying enzymes. Furthermore, histopathological examination showed that the treatment with trans-Anethole was potent in defending the liver from CCl 4 toxic injury and restored normal hepatic architecture. Also, trans-Anethole regulated p53 and Cyclin D1 expressions in liver tissue relative to group II treated with CCl 4 . Collectively, the ndings of the study showed a strong e ciency of trans-Anethole in ameliorating the effects caused by CCl 4 through modulation of antioxidants and xenobiotic-metabolizing enzymes.

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“…Several studies credit the Olea Europaea leaf extract (OLEX) for the majority of the beneficial effects that the Mediterranean diet has on human health [ 218 , 219 , 220 , 221 , 222 ]. Initially, the richness of monounsaturated fatty acids (MUFA), and in particular that of oleic acid, was considered the major healthful characteristic of OLEX.…”

Section: Candidates For Nutraceutical Supplementation In the Failimentioning

confidence: 99%

Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review

et al. 2021

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There is evidence demonstrating that heart failure (HF) occurs in 1–2% of the global population and is often accompanied by comorbidities which contribute to increasing the prevalence of the disease, the rate of hospitalization and the mortality. Although recent advances in both pharmacological and non-pharmacological approaches have led to a significant improvement in clinical outcomes in patients affected by HF, residual unmet needs remain, mostly related to the occurrence of poorly defined strategies in the early stages of myocardial dysfunction. Nutritional support in patients developing HF and nutraceutical supplementation have recently been shown to possibly contribute to protection of the failing myocardium, although their place in the treatment of HF requires further assessment, in order to find better therapeutic solutions. In this context, the Optimal Nutraceutical Supplementation in Heart Failure (ONUS-HF) working group aimed to assess the optimal nutraceutical approach to HF in the early phases of the disease, in order to counteract selected pathways that are imbalanced in the failing myocardium. In particular, we reviewed several of the most relevant pathophysiological and molecular changes occurring during the early stages of myocardial dysfunction. These include mitochondrial and sarcoplasmic reticulum stress, insufficient nitric oxide (NO) release, impaired cardiac stem cell mobilization and an imbalanced regulation of metalloproteinases. Moreover, we reviewed the potential of the nutraceutical supplementation of several natural products, such as coenzyme Q10 (CoQ10), a grape seed extract, Olea Europea L.-related antioxidants, a sodium–glucose cotransporter (SGLT2) inhibitor-rich apple extract and a bergamot polyphenolic fraction, in addition to their support in cardiomyocyte protection, in HF. Such an approach should contribute to optimising the use of nutraceuticals in HF, and the effect needs to be confirmed by means of more targeted clinical trials exploring the efficacy and safety of these compounds.

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Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

Cited by 25 publications

References 50 publications

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review

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