Standardization Study of Ghritas

Shaila, D.; Santosh, M. K.; Chandrakumar, T.; Rao, I. Sanjeeva

doi:10.1155/2004/609058

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…Physico-Chemical Evaluation of both Ghrita Formulations was done as per the methods described in Protocol for testing of Ayurvedic, Siddha and Unani medicines, (Ayush, 2008) for the parameters like colour, odour, taste, saponi ication value, iodine value, acid value and refractive index (Shaila and Santosh, 2004)…”

Section: Physico-chemical Evaluation Of Both Ghrita Formulationsmentioning

confidence: 99%

Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats

Shaikh¹,

Murthy²,

Shete³

et al. 2019

ijrps

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Previous studies proved the wound healing potential of Tilvadi Ghrita (TG) and Durva Ghrita (DG) on normal wounds, so this study was conducted to investigate wound healing activity of TG and DG on diabetic wound model in rats. Forty-eight adult female Wistar rats in eight groups were used. Alloxan was used to induce diabetes in diabetic groups. Excision wound was made on the dorsal shaved surface of rats, and then Framycetin sulfate cream (FSC) 10%, TG and DG were applied in control and treatment groups. While in normal control and diabetic control groups, no medication was done. Wound photographs were taken on alternative days to evaluate wound healing. Percentage wound contraction, the effect on wound size, and epithelization period parameters were studied. Ghritas were investigated for their preliminary phytochemicals, Physico-chemical properties, skin irritation test, and wound healing activity in normal and diabetic rats. Data were expressed as mean ± SEM and analyzed using Two-way ANOVA followed by Bonferroni’s multiple range test. Studies revealed that TG and DG do not cause any harmful skin reactions, so both ghritas were found to be safe for topical application. Both formulations showed better and fast healing as compared to untreated normal and diabetic control groups. After comparative investigation, it was observed that DG possesses higher wound healing potential in normal and diabetic groups with comparison to TG. Wound healing action in normal and diabetic wounds, it endowed due to the presence of different phytoconstituents reported in the literature and proved to be beneficial in the management of wounds.

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Section: Physico-chemical Evaluation Of Both Ghrita Formulationsmentioning

confidence: 99%

Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats

Shaikh¹,

Murthy²,

Shete³

et al. 2019

ijrps

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“…It has four fold aims (i) to dissolve/extract/hold the lipid soluble active therapeutic principles from the plants and minerals, (ii) to make use of therapeutic values of ghee, (iii) to preserve the drug/drugs for longer time (enhanced shelf life), and (iv) to enhance and hasten the absorption of drugs, when used topically in fatty medias. [ 7 8 9 ] Kuṅkumādi Ghṛta (KG) is one such Ghṛta based widely used formulation in therapeutics. Ghṛta preparations are mentioned to have shelf life of 16 months as per Ayurvedic classics and shelf life notification of Government of India.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical screening and shelf life evaluation of Kuṅkumādi Ghṛta prepared using Kesara and Nāgakesara

et al. 2017

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Introduction:Kuṅkumādi Ghṛta (KG) is an Ayurvedic formulation commonly recommended in skin disorders, especially Mukhadūṣikā (Acne vulgaris). Kesara (stigma of Crocus sativus Linn.) is a prime ingredient in the formulation. However, due to high cost and increased adulteration in Kesara, ‘Nāgakesara’ (Mesua ferrea Linn.) is suggested by Ayurvedic experts as a substitute. Nāgakesara is relatively lower in cost and possesses similar therapeutic attributes to that of Kesara. Recent studies have established standard manufacturing procedures and clinical efficacies of Kesarayukta (with Kesara) Kuṅkumādi Ghṛta (KKG) and Nāgakesara yukta (with Nāgakesara) Kuṅkumādi Ghṛta (NKG) in Mukhadūṣikā. In spite of wide utility of KG in Ayurvedic practice, no published work on its shelf life is available so far.Aims and Objectives:To establish the physicochemical profile and evaluate the shelf life of KKG and NKG.Materials and Methods:Total three batches of KKG and NKG each were prepared in the laboratory by adopting Ayurvedic classical guidelines and the findings were systematically recorded. Comparative differences in organoleptic characters (colour, odour, taste, touch) and values of different physicochemical parameters (Ash value, pH value, Total solid content, Specific gravity, Refractive index, Loss on drying, Acid value, Iodine value, Saponification value, Peroxide value and Rancidity tests) of raw materials [herbal ingredients, Go Ghṛta, Mūrcchita Ghṛta (MG)] as well as finished products (KKG and NKG) were recorded. Long term (real time) shelf life testing was carried out at the intervals i.e., at 0, 3, 6, 9 and 16 months. High performance thin layer chromatography (HPTLC) analysis of samples was also carried out.Results and Conclusion:The average percentage loss in final product was 10.18% in KKG and 7.58% in NKG. The shelf life of MG, KKG and NKG is 16 months. After 16 months, Go Ghṛta showed negative rancidity test, while MG, KKG and NKG showed positive rancidity, indicative of onset of deterioration after 16 months. Present findings validate the Ayurvedic principles stipulating medicated Ghṛta to have a shelf life of 16 months. Chromatographic study showed few differences between KKG and NKG samples. Data obtained by present study may be considered as standard for future researches.

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“…Ghritas were preparations in which oil or ghee was boiled with prescribed kasaya and kalka (fine paste of herbs) according to the formula until the aqueous portion evaporated and this process is called “avartana”. This process ensured transfer of the active botanical ingredients (ABIs) into the oil base [ 3 , 6 ]. Some researchers claimed that these preparations were drug delivery systems to deliver poorly water soluble contents or in other words, the contents that have good lipid solubility [ 4 , 6 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…This process ensured transfer of the active botanical ingredients (ABIs) into the oil base [ 3 , 6 ]. Some researchers claimed that these preparations were drug delivery systems to deliver poorly water soluble contents or in other words, the contents that have good lipid solubility [ 4 , 6 - 10 ]. On the contrary, the ABIs transferred from the decoctions should be polar, hydrophilic components since the extraction was made by boiling the herbals in water [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Reverse engineering of Ayurvedic lipid based formulation, ghrita by combined column chromatography, normal and reverse phase HPTLC analysis

Duraipandi

Selvakumar

2015

BMC Complement Altern Med

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BackgroundGhritas are ayurvedic lipid based preparations in which oil or ghee is boiled with prescribed kasaya (polyherbal decoction) and kalka (fine paste of herbs) until the evaporation of aqueous phase transfers the contents into oily phase. The polyherbal decoction used in the preparation predominantly contains water soluble Active Botanical Ingredients (ABIs).MethodsThe column chromatography was used to fractionate the ghrita into polar and non-polar fractions on silica gel as adsorbent using petroleum ether and mixture of ethanol, methanol & water as eluents. These fractions were further analysed by normal and reverse phase HPTLC analysis for the presence of the contents and its polarity.ResultsThe results showed that all the ABIs present in the formulation were polar since the fractionated non-polar fraction did not show the presence of any active botanical ingredients on normal and reverse phase HPTLC analysis.ConclusionsThe ayurvedic system of medicine has got its own technique of incorporating the polar contents into a lipid base for enhanced absorption and delivery of the ABIs at targets

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Standardization Study of Ghritas

Cited by 7 publications

References 2 publications

Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats

Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats

Physicochemical screening and shelf life evaluation of Kuṅkumādi Ghṛta prepared using Kesara and Nāgakesara

Reverse engineering of Ayurvedic lipid based formulation, ghrita by combined column chromatography, normal and reverse phase HPTLC analysis

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