2005
DOI: 10.1590/s1678-91992005000200004
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Standardization of the PCR technique for the detection of delta toxin in Staphylococcus spp.

Abstract: Coagulase-negative staphylococci (CNS), components of the normal flora of neonates, have emerged as important opportunistic pathogens of nosocomial infections that occur in neonatal intensive care units. Some authors have reported the ability of some CNS strains, particularly Staphylococcus epidermidis, to produce a toxin similar to S. aureus delta toxin. This toxin is an exoprotein that has a detergent action on the membranes of various cell types resulting in rapid cell lysis. The objectives of the present s… Show more

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Cited by 15 publications
(8 citation statements)
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“…The δ-hemolysin gene, hld , was detected using the primers and parameters described by Marconi et al [ 46 ].…”
Section: Methodsmentioning
confidence: 99%
“…The δ-hemolysin gene, hld , was detected using the primers and parameters described by Marconi et al [ 46 ].…”
Section: Methodsmentioning
confidence: 99%
“…This toxin with its detergent function degrades erythrocytes. The delta toxin may cause intestinal diseases that can vary from acute diarrhea to severe enteritis [15,17,18]. Because the association between antimicrobial resistance and virulence factors of CoNS isolates had never been done before as well as in a similar work in staphylococcus aureus strains observed a significant relationship between antibiotic resistance and hemolysin genes thus we made attempt to determine this association in this study.…”
Section: Introductionmentioning
confidence: 96%
“…PCR was used to detect genes that encode the following toxins: classical enterotoxins ( sea , seb , and sec -1) [ 19 , 20 ], panton–valentine leukocidin (PVL) ( luk PV) [ 21 ], toxic shock syndrome toxin 1 ( tst ) [ 19 , 20 ], exfoliative toxins A and B ( eta and etb ) [ 22 ], and cytotoxins ( hla and hld ) [ 23 ].…”
Section: Methodsmentioning
confidence: 99%