Standardization of equine infectious anemia immunodiffusion and celisa tests and their application to control of the disease in the united states

Pearson, J.; Gipson, Chester

doi:10.1016/s0737-0806(88)80113-8

Cited by 16 publications

(14 citation statements)

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“…The use of this test allowed the efficient control of EIAV infection in the United States. Between 1972 and 1984, the number of AGID-positive animals decreased from 3.9% to 0.38% [130]. The major drawback of this test is that it is time consuming and sometimes difficult to interpret.…”

Section: Control Of Eiav Infectionmentioning

confidence: 99%

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

2004

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-Equine Infectious Anemia Virus (EIAV) is a lentivirus, of the Retrovirus family, with an almost worldwide distribution, infecting equids. It causes a persistent infection characterized by recurring febrile episodes associating viremia, fever, thrombocytopenia, and wasting symptoms. The disease is experimentally reproducible by inoculation of Shetland ponies or horses with EIAV pathogenic strains. Among lentiviruses, EIAV is unique in that, despite a rapid virus replication and antigenic variation, most animals progress from a chronic stage characterized by recurring peaks of viremia and fever to an asymptomatic stage of infection. The inapparent carriers remain infective for life, as demonstrated by experimental transfer of blood to naive animals. The understanding of the correlates of this immune control is of great interest in defining vaccine strategies. Research on EIAV, this "country cousin" of HIV (Human Immunodeficiency Virus), over the last five decades has produced some interesting results on natural immunological control of lentivirus replication and disease and on the nature and role of virus variation in persistence and pathogenesis. These studies are of interest in the context of HIV and efforts to develop a vaccine. This review will focus on some of the most recent results. equine infectious anemia virus / lentivirus / equids / vaccine / viral evolution

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Section: Control Of Eiav Infectionmentioning

confidence: 99%

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

2004

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“…To control the spread of infection, horses are routinely tested at racetracks, shows, and rodeos, before breeding, and crossing borders. This effort has proven largely successful, bringing the prevalence of EIAV-positive animals down to 0.38% by 1988 [7,10].…”

Section: Introductionmentioning

confidence: 99%

Immune Control of Equine Infectious Anemia Virus Infection by Cell-Mediated and Humoral Responses

Schwartz¹,

Pawelek²,

Harrington³

et al. 2013

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Equine Infectious Anemia Virus (EIAV) is a retrovirus that establishes a persistent infection in horses and ponies. The virus is in the same lentivirus subgroup that includes human immunodeficiency virus (HIV). The similarities between these two viruses make the study of the immune response to EIAV relevant to research on HIV. We developed a mathematical model of within-host EIAV infection dynamics that contains both humoral and cell-mediated immune responses. Analysis of the model yields results on thresholds that would be necessary for a combined immune response to successfully control infection. Numerical simulations are presented to illustrate the results. These findings have the potential to lead to immunological control measures for lentiviral infection.

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“…EIA infection is widely reported in several countries (Pearson and Knowles 1984;Lew et al 1993;Nagarajan and Simard 2001). Although EIA has not been reported in the border countries of Ardahan (Armenia and Georgia) so far, the presence of hematophagous vectors are important risk factors of EIA for equines (Erdem 2007).…”

Section: Discussionmentioning

confidence: 99%

Serosurveillance for equine infectious anaemia in the Ardahan province of Turkey

Albayrak

Özan²

2010

Trop Anim Health Prod

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Equine infectious anaemia is a retroviral infection of horses. All infected horses, including those that are asymptomatic, become carriers and are infectious for life. In this study, blood samples of all equines in the province of Ardahan were collected. The material consisted of 8,947 equines, including 8,769 horses and 178 donkeys, from Ardahan province in northeastern Turkey. Blood was collected from all horses and donkeys and the sera were analysed for the presence of antibodies to equine infectious anaemia virus (EIAV) using an enzyme-linked immunosorbent assay. The results revealed that none of the horses and donkeys were positive for antibodies to EIAV.

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Standardization of equine infectious anemia immunodiffusion and celisa tests and their application to control of the disease in the united states

Cited by 16 publications

References 0 publications

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

Immune Control of Equine Infectious Anemia Virus Infection by Cell-Mediated and Humoral Responses

Serosurveillance for equine infectious anaemia in the Ardahan province of Turkey

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