Standardization and anti-inflammatory activity of aqueous extract of Psittacanthus plagiophyllus Eichl. (Loranthaceae)

Bezerra, Adrielle Nara Serra; Massing, Laís Tatiele; Oliveira, Rodrigo Santos de; Mourão, Rosa Helena Veras

doi:10.1016/j.jep.2017.03.029

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…3S and 5S), we can indicate that the signals between 7.5 and 6.5 ppm correspond to polyphenolic compounds (flavonoids) (Apaza Ticona et al 2021). These extracts rich in polyphenolic compounds may have anti-inflammatory activity (Bezerra et al 2017). In our case, based on the literature and the assays that we carried out, we can indicate that its mechanism of action is inhibition of TNF-α by downregulation gene expression for NF-κB.…”

Section: Effect On the Inflammatory Parametersmentioning

confidence: 85%

Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

Ticona

Pérez

Alejano

et al. 2021

Rev. Bras. Farmacogn.

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Two glycosylated flavonoids, the quercetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside and myricetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside, were isolated from the CH2Cl2/MeOH fraction of Syzygium jambos (L.) Alston, Myrtaceae. The structures of these compounds were elucidated by spectroscopic means. The cytotoxicity of the compounds was evaluated against the RAW 264.7 cell lines by the lactate dehydrogenase assay. All analyzed compounds were less cytotoxic than the positive control (actinomycin D, CC50 = 0.008 μM). The anti-inflammatory and anti-arthritic activities were evaluated by measuring inflammatory parameters in murine models. The two glycosylated flavonoids inhibited the production of tumor necrosis factor-α in RAW 264.7 cell line with IC50 of 1.68 and 1.11 μM, respectively. In addition, all flavonoids decreased the levels of tumor necrosis factor-α, C-reactive protein, and fibrinogen at a dose of 5 mg/kg in murine models. Graphical abstract

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Section: Effect On the Inflammatory Parametersmentioning

confidence: 85%

Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

Ticona

Pérez

Alejano

et al. 2021

Rev. Bras. Farmacogn.

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“…Data of morphology, weight, FAMACHA, body condition score and blood variables were analyzed using comparison of means, performed using two-way ANOVA for comparison between groups and time (repeated measures) and then compared using the Tukey test. The data were analyzed using JMP 8 4 and values were considered significant at P ≤ 0.05.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers reported that quebracho tannins stimulated the immune response and caused protective effects on the intestinal mucosa in sheep experimentally infected with gastrointestinal parasites [26]. Researchers, using aqueous extracts of Psittacanthus plagiophyllus containing 5.39% of tannins, reported potent anti-inflammatory effects, reducing the total count of leukocytes and lymphocytes in a model of inflammation induced by carrageenan [4]. In another study, the supplementation with quebracho extract (0.5 and 1%) promoted anti--inflammatory effects on leukocytes, and the concentration of globulins increased, stimulating the immune response, similar to what was observed in the present study with the greater doses of tannins.…”

Section: Discussionmentioning

confidence: 99%

Addition of Tannin in Lamb Diets after Weaning: Impact on Performance and Hematological and Biochemical Variables

Lucianer

Silva

Cazarotto

et al. 2019

Acta Scientiae. Vet.

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Background:In ruminants, the weaning period is a critical phase, because these young animals are allocated to various facilities and receive different feeds. Alternatively, supplements and additives can be used. The tannins are polyphenols produced by plants; constitute a group of complex secondary metabolic factors that inhibit the consumption by herbivores or the development of microbial agents. The objective of this study was to determine whether the addition of condensed tannin extract from quebracho trees (Schinopsis lorentzii) in lamb diets after weaning would have beneficial effects on growth and health. Materials, Methods & Results:Forty lambs were assigned randomly to 1 of 4 treatments (10 lambs/treatment): T1 (0%; control), T2, T3, and T4 was 0.3, 0.6 and 0.9 % of quebracho extract in the diet, respectively. The T2 (0.3%) lambs had greater body condition scores (P = 0.005), and although they did not differ significantly, they had numerically greater body weight (P = 0.067) and weight gain (P = 0.072), than the control lambs. The anthelmintic and anticoccidial effect was not possible to verify because no animals in any group were naturally infected by helminths or coccidia. The T4 lambs had greater numbers of erythrocytes (days 10 and 40) [P < 0.05], greater hemoglobin concentrations (days 10 and 40), and greater numbers of total leukocytes (day 10) as a result of greater numbers of neutrophil at the end of the adaptation period (day 10) compared to T1. The T3 and T4 lambs had greater (P < 0.05) serum total protein (days 10 and 40) because of greater concentration of serum globulins (days 10 and 40) compared to T1, suggesting that the addition of tannin stimulated the immune system. The addition of quebracho in the diet affected serum concentrations of glucose, triglycerides, and cholesterol at some times and treatments (P < 0.05). However, these changes did not follow a pattern; this finding only suggested that there was an influence on the metabolism of carbohydrates and lipids. The T2 lambs showed no differences on hemogram or serum clinic biochemistries (P > 0.05); however, they had a greater body condition scores than T1 (P < 0.05). Discussion: According to literature, if condensed tannins are supplied in moderate quantities (≤ 5% of diet) to ruminants, they can prevent bloating, increase the supply of undegraded protein in the rumen and improve the use of essential amino acids. It is also known that tannins in diet may increase urea recycling efficiency by increasing the concentration of urea in saliva and salivary flow into the rumen. Studies observed that cattle and sheep given feed containing condensed tannins had higher production of wool, meat, milk, and ovulation rates in females, desirable effects on animal production. According to the literature, dietary supplementation with tannins from chestnut and quebracho (2 g/kg of feed) to Holstein cattle changed the composition of the ruminal microbiota, particularly the bacteria that degrade fiber and starch, reducing the abundance of Prevotella an...

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“…The global paw oedema evolution process for the groups treated with microemulsion was different from the negative control group and the group treated with diclofenac (ANOVA, p < 0.05 ). Dextran generates an osmotic oedema caused by the mast cells degranulation with the release of histamine and serotonin and increase of vascular permeability [ 51 , 52 ]. The decrease of the pow oedema of the animals treated with the juniper microemulsion indicates anti-histamine and anti-serotine activity properties, in the dextran experimental model used.…”

Section: Discussionmentioning

confidence: 99%

Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills

Fierăscu

Ungureanu

Avramescu

et al. 2018

BMC Complement Altern Med

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BackgroundJuniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.MethodsThe prepared hydroethanolic extract of Juniperus communis L. was characterized by GC-MS, HPLC, UV-Vis spectrometry and phytochemical assays. The antioxidant potential was evaluated using the DPPH assay, the antifungal effect was studied on Aspergillus niger ATCC 15475 and Penicillium hirsutum ATCC 52323, while the genoprotective effect was evaluated using the Allium cepa assay. The anti-inflammatory effect was evaluated in two inflammation experimental models (dextran and kaolin) by plethysmometry. Male Wistar rats were treated by gavage with distilled water (negative control), the microemulsion (positive control), diclofenac sodium aqueous solution (reference) and microemulsions containing juniper extract (experimental group). The initial paw volume and the paw volumes at 1, 2, 3, 4, 5 and 24 h were measured.ResultsTotal terpenoids, phenolics and flavonoids were estimated to be 13.44 ± 0.14 mg linalool equivalent, 19.23 ± 1.32 mg gallic acid equivalent, and 5109.6 ± 21.47 mg rutin equivalent per 100 g of extract, respectively. GC-MS characterization of the juniper extract identified 57 volatile compounds in the sample, while the HPLC analysis revealed the presence of the selected compounds (α-pinene, chlorogenic acid, rutin, apigenin, quercitin). The antioxidant potential of the crude extract was found to be 81.63 ± 0.38% (measured by the DPPH method). The results of the antifungal activity assay (for Aspergillus niger and Penicillium hirsutum) were 21.6 mm, respectively 17.2 mm as inhibition zone. Test results demonstrated the genoprotective potential of J. communis undiluted extract, inhibiting the mitodepressive effect of ethanol. The anti-inflammatory action of the juniper extract, administered as microemulsion in acute-dextran model was increased when compared to kaolin subacute inflammation induced model.ConclusionThe hydroalcoholic extract obtained from wild-growing Juniperus communis native to Romanian southern sub-Carpathian hills has genoprotective, antioxidant, antifungal and anti-inflammatory properties.

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Standardization and anti-inflammatory activity of aqueous extract of Psittacanthus plagiophyllus Eichl. (Loranthaceae)

Abstract: These findings provide evidence to support the use of P. plagiophyllus in folk medicine to treat inflammatory disorders.

Cited by 14 publications

References 34 publications

Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

Addition of Tannin in Lamb Diets after Weaning: Impact on Performance and Hematological and Biochemical Variables

Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills

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