Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

Abstract

Two glycosylated flavonoids, the quercetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside and myricetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside, were isolated from the CH2Cl2/MeOH fraction of Syzygium jambos (L.) Alston, Myrtaceae. The structures of these compounds were elucidated by spectroscopic means. The cytotoxicity of the compounds was evaluated against the RAW 264.7 cell lines by the lactate dehydrogenase assay. All analyzed compounds were less cytotoxic than the positive control (actinomycin D, CC50 = 0.008 μM). The anti-inflammatory and anti-arthritic activities were evaluated by measuring inflammatory parameters in murine models. The two glycosylated flavonoids inhibited the production of tumor necrosis factor-α in RAW 264.7 cell line with IC50 of 1.68 and 1.11 μM, respectively. In addition, all flavonoids decreased the levels of tumor necrosis factor-α, C-reactive protein, and fibrinogen at a dose of 5 mg/kg in murine models. Graphical abstract

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

“…Potent antioxidant activity was also observed in the FRAP assay (Table 4). It is well established through the in vitro assays that S. jambos has substantial antioxidant potential (Ticona et al, 2021). This was also supported by the studies of Sobeh et al, who reported that the Egyptian S. jambos harbors plenty of phenolic compounds such as flavonol glycosides, flavones ellagitannins, and phenolic acids, which are known to be endowed with strong antioxidant properties (Sobeh et al, 2018a).…”

Anti-arthritic efficacy of Bombax ceiba ethanolic extract in a murine model for rheumatoid arthritis using in vivo, in vitro and radiological analysis

“…A variety of mediators, including cytokines (IL-1B and TNF-alpha), GM-CSF, interferons, and PGDF, are released during chronic inflammation. These mediators are responsible for pain, bone and cartilage degradation, and severe impairment [ 21 ].Standard drug and hydro-alcoholic Bombax ceiba extract, on the other hand, can significantly suppress paw swelling and decrease paw volume in both acute and chronic phases, which may be due to the suppression of inflammatory mediators released due to Freund's adjuvant induction [ 22 ]. Though the exact mechanism of inflammation suppression is unknown, it can be connected with the presence of alkaloids and flavonoids in suppressing inflammation and antioxidant activity [ 23 ].…”

Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer

“…These phytocompounds are broadly involved in health-promoting effects and crucial components in a variety of pharmaceutical, nutraceutical, medicinal and cosmetic applications. (14) These are also associated with their anti-oxidative (40), anti-mutagenic (41), anti-inflammatory (42), and anti-carcinogenic (43) properties. Some researchers reported the tremendous scope of flavonoids as potential drugs in preventing chronic diseases and future research directions.…”