Standardisation and half-life measurements of  111 In

Dziel, Tomasz; Listkowska, A.; Tymiński, Z.

doi:10.1016/j.apradiso.2015.11.105

Cited by 6 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can easily require a time frame longer than 24 h, but the half-life time of radioisotopes, like 18 F or 68 Ga, is only 110 or 68 min, respectively. Thus, long-lived radionuclides would be necessary, which would, however, lead to a higher radiation dose for the patient. − To circumvent this problem, a pretargeting approach based on bioorthogonal in vivo reactions can be used to employ short-lived radionuclides in combination with slowly accumulating targeting vectors such as nanoparticles . In this approach, a targeting vehicle, modified with reactive moieties for biorthogonal reactions, is first administered.…”

Section: Some Aspects Of Intentional Bioconjugationmentioning

confidence: 99%

Nanoparticular Carriers As Objects to Study Intentional and Unintentional Bioconjugation

Zentel

2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Synthetic nanoparticles are interesting to use in the study of ligation with natural biorelevant structures. That is because they present an intermediate situation between reactions onto soluble polymers or onto solid surfaces. In addition, differently functionalized nanoparticles can be separated and studied independently thereafter. So what would be a "patchy functionalization" on a macroscopic surface results in differently functionalized nanoparticles, which can be separated after the interaction with body fluids. This paper will review bioconjugation of such nanoparticles with a special focus on recent results concerning the formation of a protein corona by unspecific adsorption (lower lines of TOC), which presents an unintentional bioconjugation, and on new aspects of intentionally performed bioconjugation by covalent chemistry (upper line). For this purpose, it is important that polymeric nanoparticles without a protein corona can be prepared. This opens, e.g., the possibility to look for special proteins adsorbed as a result of the natural compound ligated to the nanoparticle by covalent chemistry, like the Fc part of antibodies. At the same time, the use of highly reactive, bioorthogonal functional groups (inverse electron demand Diels−Alder cycloaddition) on the nanoparticles allows an efficient ligation after administration inside the body, i.e., in vivo.

show abstract

Section: Some Aspects Of Intentional Bioconjugationmentioning

confidence: 99%

Nanoparticular Carriers As Objects to Study Intentional and Unintentional Bioconjugation

Zentel

2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…The energy window setting is also an important factor for SPECT imaging, as it affects the quantitative accuracy [16]. 111 In, which has a physical half-life of 2.8 days, decays by orbital electron capture, emitting γ-rays (171 keV: 90.2%, 245 keV: 94.0%) and characteristic X-rays (Kα: 23.1 keV, 69.0%; Kβ: 26.2 keV, 14.1%) [17,18]. In the case of bone scintigraphy, it has been reported that the quanti cation accuracy is improved by optimizing the energy window [19].…”

Section: Introductionmentioning

confidence: 99%

Development of a New Quantification Method Using Partial Volume Effect Correction for Individual Energy Peaks in 111In-pentetreotide SPECT/CT

Yamashita

Miyaji

Motegi

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundSomatostatin receptor scintigraphy (SRS) using 111In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in 111In-pentetreotide single-photon emission computed tomography (SPECT). MethodsPhantom experiments were performed to construct a new quantitative method. In the phantom experiments, a NEMA IEC body phantom was used. Acquisition was performed using two energy peaks (171 keV and 245 keV) on the SPECT/CT system. In the SPECT images of each energy peak, the region of interest was set at each hot sphere and lung insert, and the recovery coefficient (RC) was calculated to understand the PVE. A new quantitative index, the indium uptake index (IUI), was calculated using the RC to correct the PVE. The quantitative accuracy of the IUI in the hot sphere was confirmed. Case studies were performed to clarify the quantitative accuracy. In a case study, the relationship between the IUI and the Krenning score, which is used as a visual assessment, was evaluated for each lesion. ResultsThe obtained RCs showed that the energy peak at 171 keV was faster in recovering the effect of PVE than that at 245 keV. The IUI in the 17 mm diameter hot sphere was overestimated by 3.1% at 171 keV and underestimated by 0.5% at 245 keV compared to the actual IUI. In case studies, the relationship between IUI and Krenning score was rs = 0.805 (p < 0.005) at sum, rs = 0.77 (p < 0.005) at 171 keV, and rs = 0.84 (p < 0.005) at 245 keV.Conclusion We have developed a new quantification method for 111In-pentetreotide SPECT/CT using RC-based PVE correction for an individual energy peak of 171 keV. The quantitative accuracy of this method was high even for accumulations of less than 20 mm, and it showed a good relationship with the Krenning score; therefore, the clinical usefulness of IUI was demonstrated.

show abstract

“…Thus, long-lived radionuclides such as 111 In or 89 Zr with half-life times of 2.8 and 3.3 days would be necessary. 26,27 This would, however, lead to a higher radiation dose for the patient. 23 To circumvent this problem, a pretargeting approach based on bioorthogonal in vivo reactions 28 can be used to employ short-lived radionuclides for slowly accumulating targeting vectors such as nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…However, many applications that are based on the accumulation of nanoparticles within the tumor tissue through the EPR-effect require a longer time frame of more than 24 h before imaging. Thus, long-lived radionuclides such as 111 In or 89 Zr with half-life times of 2.8 and 3.3 days would be necessary. , This would, however, lead to a higher radiation dose for the patient . To circumvent this problem, a pretargeting approach based on bioorthogonal in vivo reactions can be used to employ short-lived radionuclides for slowly accumulating targeting vectors such as nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation

et al. 2019

View full text Add to dashboard Cite

Fast and bioorthogonally reacting nanoparticles are attractive tools for biomedical applications such as tumor pretargeting. In this study, we designed an amphiphilic block copolymer system based on HPMA using different strategies to introduce the highly reactive click units 1,2,4,5-tetrazines (Tz) either at the chain end (Tz-CTA) or statistical into the hydrophobic block. This reactive group undergoes a rapid, bioorthogonal inverse electron-demand Diels–Alder reaction (iEDDA) with trans-cyclooctenes (TCO). Subsequently, this polymer platform was used for the preparation of different Tz-covered nanoparticles, such as micelles and colloids. Thereby it was found that the reactivity of the polymeric micelles is comparable to that of the low molar mass tetrazines. The core-cross-linked micelles can be successfully conjugated at rather low concentrations to large biomacromolecules like antibodies, not only in physiological buffer, but also in human blood plasma, which was confirmed by fluorescence correlation spectroscopy (FCS).

show abstract

Standardisation and half-life measurements of 111 In

Cited by 6 publications

References 8 publications

Nanoparticular Carriers As Objects to Study Intentional and Unintentional Bioconjugation

Nanoparticular Carriers As Objects to Study Intentional and Unintentional Bioconjugation

Development of a New Quantification Method Using Partial Volume Effect Correction for Individual Energy Peaks in 111In-pentetreotide SPECT/CT

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation

Contact Info

Product

Resources

About