Standard uptake value and metabolic tumor volume of 18F-FDG PET/CT predict short-term outcome early in the course of chemoradiotherapy in advanced non-small cell lung cancer

Huang, Wei; Zhou, Tao; Ma, Li; Sun, Hao; Gong, Huaqing; Wang, Juan; Yu, Jinming; Li, Baosheng

doi:10.1007/s00259-011-1838-5

Cited by 103 publications

(96 citation statements)

References 20 publications

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“…We chose the most intense point on each malignant lesion and drew the lesion boundaries using SUV-based contouring software. A fixed 50 % of local maximum intensity was used as the threshold intensity value, and this was deemed reasonable from previous studies [16][17][18]. When the automated software included not only malignant lesions but also background activity, we manually removed the background boundaries by reviewing the background CT findings.…”

Section: Image Interpretation and Quantitationmentioning

confidence: 99%

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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Purpose The aim of this study was to evaluate the relationship between semiquantitative parameters on 18 F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18 F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18 F-FDG PET/ CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p= 0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of 18 F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18 F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

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Section: Image Interpretation and Quantitationmentioning

confidence: 99%

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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“…Lung cancer is the leading cause of cancer death in the world, and 80-85 % of lung cancer cases are classified as non-small cell lung cancer (NSCLC) [1]. The outcome for patients with NSCLC remains quite poor despite improvements in radiotherapy and chemotherapy in the past decade [2].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Tumor Volume Measured by F-18 FDG PET/CT can Further Stratify the Prognosis of Patients with Stage IV Non-Small Cell Lung Cancer

Yoo

Kim

Chong

et al. 2012

Nucl Med Mol Imaging

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Purpose This study aimed to further stratify prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Materials and MethodsThe subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F-18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were measured by receiver operating characteristic (ROC) curve analysis. Kaplan-Meier survival curves were used for evaluation of progression-free survival (PFS). The univariate and multivariate Cox proportional hazards models were used to select the significant prognostic factors. Results Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV-lung and TLG-lung) were significant factors for prediction of PFS (P<0.001, P00.038, respectively). Patients showing lower values of MTV-lung and TLG-lung than the cutoff values had significantly longer mean PFS than those with higher values. Hazard ratios (95 % confidence interval) of MTV-lung and

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“…The potential of FDG-PET/CT for staging in patients with diagnosed NSCLC has been demonstrated [2,23]. Based on SUV changes, 18 F-FDG uptake can determine patient prognoses after treatment [24,25] and predict tumor response [26]. On the other hand, DWI also has an established role in tumor detection [11] and response assessment.…”

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confidence: 99%

Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Heusch¹,

Buchbender²,

Köhler

et al. 2013

Fortschr Röntgenstr

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Purpose: To compare the apparent diffusion coefficient (ADC) in non-small cell lung cancer lesions with standardized uptake values (SUV) derived from combined 18F-fluoro-deoxy-glucose-positron emission tomography/magnetic resonance imaging (FDG-PET/MRI) and those derived from FDG-PET/CT. Materials and Methods: In 18 consecutive patients with histologically proven NSCLC (17 men, 1 woman; mean age, 61???12 years), whole-body FDG-PET/MRI was performed after whole-body FDG-PET/CT. Regions of interest (ROI) encompassing the entire primary tumor were drawn into FDG-PET/CT and FDG-PET/MR images to determine the maximum and mean standardized uptake value (SUVmax; SUVmean) and into ADC parameter maps to assess mean ADC values. Pearson?s correlation coefficients were calculated to compare SUV and ADC values. Results: The SUVmax of NSCLC was 12.3???4.8 [mean ?SD], and the SUVmean was 7.2???2.8 as assessed by FDG-PET/MRI. The SUVmax and SUVmean derived from FDG-PET/CT and FDG-PET/MRI correlated well (R?=?0.93; p?

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Standard uptake value and metabolic tumor volume of 18F-FDG PET/CT predict short-term outcome early in the course of chemoradiotherapy in advanced non-small cell lung cancer

Abstract: SUV and MTV changes from two serial (18)F-FDG PET/CT scans, before and after initial CRT, allow prediction of the treatment response in advanced NSCLC.

Cited by 103 publications

References 20 publications

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Metabolic Tumor Volume Measured by F-18 FDG PET/CT can Further Stratify the Prognosis of Patients with Stage IV Non-Small Cell Lung Cancer

Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

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