Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging

Li, Ming; Lü, Jing; Qi, Ji; Zhao, Fei; Zeng, Jin; Yu, Jorn C. C.; Shih, Wei-Chuan

doi:10.1117/1.jbo.19.5.050501

Cited by 47 publications

(30 citation statements)

References 17 publications

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“…1,4,5,[14][15][16][17] An ultimate goal in this field is to develop Raman spectroscopy-based techniques for biomedical applications through instrumentation, [18][19][20][21][22] plasmonic substrates, [23][24][25][26][27] devices, 28,29 assays, 30,31 and techniques. 32,33 Raman spectroscopic measurements, like other optical techniques, pose minimal danger from exposure to ionizing radiation due to the low-energy optical radiation exposure. One additional advantage of the NIR source used in Raman is that the tissue sampling region is much deeper than those provided by other optical approaches due to the reduced tissue scattering and reduced water and chromophore absorption at those wavelengths.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive glucose sensing by transcutaneous Raman spectroscopy

2015

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Abstract. We present the development of a transcutaneous Raman spectroscopy system and analysis algorithm for noninvasive glucose sensing. The instrument and algorithm were tested in a preclinical study in which a dog model was used. To achieve a robust glucose test system, the blood levels were clamped for periods of up to 45 min. Glucose clamping and rise/fall patterns have been achieved by injecting glucose and insulin into the ear veins of the dog. Venous blood samples were drawn every 5 min and a plasma glucose concentration was obtained and used to maintain the clamps, to build the calibration model, and to evaluate the performance of the system. We evaluated the utility of the simultaneously acquired Raman spectra to be used to determine the plasma glucose values during the 8-h experiment. We obtained prediction errors in the range of ∼1.5 − 2 mM. These were in-line with a best-case theoretical estimate considering the limitations of the signal-to-noise ratio estimates. As expected, the transition regions of the clamp study produced larger predictive errors than the stable regions. This is related to the divergence of the interstitial fluid (ISF) and plasma glucose values during those periods. Two key contributors to error beside the ISF/plasma difference were photobleaching and detector drift. The study demonstrated the potential of Raman spectroscopy in noninvasive applications and provides areas where the technology can be improved in future studies.

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Section: Introductionmentioning

confidence: 99%

Noninvasive glucose sensing by transcutaneous Raman spectroscopy

2015

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“…4 PDMS has been employed to construct microfluidic devices since the 1990s, 5 and still maintains its wide applicability to date. [6][7][8][9][10] As a lens material, three types of fabrication techniques have been adopted: (1) lithographic methods, 11 (2) surface tension driven methods, 12 and (3) embossing methods. 13 These current approaches demonstrate the feasibility of creating PDMS lenses with good optical characteristics and reproducibility; however, they either require time-consuming fabrication procedures typically measured in hours, or have high costs due to lithographic and molding equipment required, and generally limit the size of the lens to the micrometer scale.…”

Section: Introductionmentioning

confidence: 99%

Fabricating optical lenses by inkjet printing and heat-assistedin situcuring of polydimethylsiloxane for smartphone microscopy

et al. 2015

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Abstract. We present a highly repeatable, lithography-free and mold-free method for fabricating flexible optical lenses by in situ curing liquid polydimethylsiloxane droplets on a preheated smooth surface with an inkjet printing process. This method enables us to fabricate lenses with a focal length as short as 5.6 mm, which can be controlled by varying the droplet volume and the temperature of the preheated surface. Furthermore, the lens can be attached to a smartphone camera without any accessories and can produce high-resolution (1 μm) images for microscopy applications.

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“…[14,15] Nanoporous plasmonic disks possess large specific surface area and high-density internal plasmonic "hot-spots" with strong electric field enhancement. Taking advantage of the high-density hot spots in NPG disks, we have developed several applications such as ultrasensitive DNA hybridization monitoring at the level of individual molecules, [16] photothermal mechanism and applications, [17,18] label-free molecular imaging and spectroscopy, [19] and integrated microfluidic SERS sensor for label-free biomolecular sensing. [20] …”

Section: Introductionmentioning

confidence: 99%

Monolithic nanoporous gold disks with large surface area and high-density plasmonic hot-spots

et al. 2015

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Plasmonic metal nanostructures have shown great potential in sensing, photovoltaics, imaging and biomedicine, principally due to enhancement of the local electric field by light-excited surface plasmons, the collective oscillation of conduction band electrons. Thin films of nanoporous gold have received a great deal of interest due to the unique 3-dimensional bicontinuous nanostructures with high specific surface area. However, in the form of semi-infinite thin films, nanoporous gold exhibits weak plasmonic extinction and little tunability in the plasmon resonance, because the pore size is much smaller than the wavelength of light. Here we show that by making nanoporous gold in the form of disks of sub-wavelength diameter and sub-100 nm thickness, these limitations can be overcome. Nanoporous gold disks (NPGDs) not only possess large specific surface area but also high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of NPGD can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. The coupling between external and internal nanoarchitecture provides a potential design dimension for plasmonic engineering. The synergy of large specific surface area, high-density hot spots, and tunable plasmonics would profoundly impact applications where plasmonic nanoparticles and non-plasmonic mesoporous nanoparticles are currently employed, e.g., in in-vitro and in-vivo biosensing, molecular imaging, photothermal contrast agents, and molecular cargos.

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Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging

Cited by 47 publications

References 17 publications

Noninvasive glucose sensing by transcutaneous Raman spectroscopy

Noninvasive glucose sensing by transcutaneous Raman spectroscopy

Fabricating optical lenses by inkjet printing and heat-assistedin situcuring of polydimethylsiloxane for smartphone microscopy

Monolithic nanoporous gold disks with large surface area and high-density plasmonic hot-spots

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