Staging reproductive aging using Stages of Reproductive Aging Workshop + 10 in black urban African women in the Study of Women Entering and in Endocrine Transition

Jaff, Nicole; Snyman, Tracy; Norris, Shane A.; Crowther, Nigel J.

doi:10.1097/gme.0000000000000235

Cited by 19 publications

(32 citation statements)

References 48 publications

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“…Participants in each stage were as follows: late reproductive (n = 194); early and late menopausal transition (n = 122); early postmenopause (n = 144) and late postmenopause (n = 130). The characteristics of this study population have been reported previously [11]. However, a brief overview of this population will be provided here as this is relevant to the current study.…”

Section: Subject Characteristicsmentioning

confidence: 94%

“…The data from the Study of Women Entering and in Endocrine Transition (SWEET) show a high rate of obesity at menopause (68%) [11] and previous investigations have shown that diabetes and metabolic syndrome are very prevalent in these women [12]. The causes of this are not known, but given the strong association between MT and changes in BFD and lean muscle mass reported in non-African populations [13], the MT may play a role.…”

Section: Introductionmentioning

confidence: 92%

“…These stages are late reproductive (−3b, −3b); early menopausal transition (−2); late menopausal transition (−1); early postmenopause (+1a, +1b, +1c) and late postmenopause (stage +2). This questionnaire has not previously been used on African females but a previous publication has shown that it is valid for staging menopause in this population [11].…”

Section: Questionnaires and Menopausal Transition Stagementioning

confidence: 99%

“…However, it is not known whether this relationship occurs across the MT and whether changes in lean mass during this period will affect BMD. In addition, the prevalence of HIV infection is high in populations of urban, mid-life black South African females [11], but it is not known whether this contributes to changes in body composition.…”

Section: Introductionmentioning

confidence: 99%

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Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection

et al. 2015

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Section: Subject Characteristicsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 92%

Section: Questionnaires and Menopausal Transition Stagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection

et al. 2015

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“…Approximately 700 of the women selected from this cohort were also part of the ‘Study of Women Entering and Endocrine Transition’ (SWEET) [28]. The remaining participants, including approximately 1000 men, were recruited through random selection using a geographical-based sampling frame that covered the Soweto region.…”

Section: Methodsmentioning

confidence: 99%

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

Ali

Soo

Agongo

et al. 2018

Global Health Action

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152

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There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent.

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The Impact of Human Immunodeficiency Virus and Menopause on Bone Mineral Density: A Longitudinal Study of Urban-Dwelling South African Women

Madanhire

Goedecke

Ward

et al. 2020

Journal of Bone and Mineral Research

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An estimated 25% of South African women live with human immunodeficiency virus (HIV). Antiretroviral therapy roll-out has improved life expectancy, so many more women now reach menopause. We aimed to quantify changes in bone mineral density (BMD) during the menopausal transition in urban-dwelling South African women with and without HIV and determine whether HIV infection modified the effect of menopause on BMD changes. A 5-year population-based longitudinal study recruited women aged 40-60 years residing in Soweto and collected demographic and clinical data, including HIV status, anthropometry, and BMD, at baseline and at 5-year follow-up. All women were staged as pre-, peri-, or postmenopausal at both time points. Multivariable linear regression assessed relationships and interactions between HIV infection, menopause, and change in BMD. At baseline, 450 women had mean age 49.5 (SD 5.7) years, 65 (14.4%) had HIV, and 140 (31.1%), 119 (26.4%), and 191 (42.4%) were pre-, peri-, and postmenopausal, respectively; 34/205 (13.6%) women ≥50 years had a total hip (TH) or lumbar spine (LS) T-score ≤ À2.5. At follow-up 38 (8.4%), 84 (18.7%), and 328 (72.9%) were pre-, peri-, and postmenopausal. Those with HIV at baseline lost more total body (TB) BMD (mean difference À0.013 [95% confidence interval À0.026, À0.001] g/cm 2 , p = 0.040) and gained more weight 1. 96 [0.32, 3.60] kg; p = 0.019 than HIV-uninfected women. After adjusting for age, baseline weight, weight change, and follow-up time, the transition from pre-to postmenopause was associated with greater TB BMD losses in women with HIV (À0.092 [À0.042, À0.142] g/cm 2 ; p = 0.001) than without HIV (À0.038 [À0.016, À0.060] g/cm 2 , p = 0.001; interaction p = 0.034). Similarly, in women who were postmenopausal at both time points, those with HIV lost more TB BMD (À0.070 [À0.031, À0.108], p = 0.001) than women without HIV (À0.036 [À0.015, À0.057], p = 0.001, interaction p = 0.049). Findings were consistent but weaker at the LS and TH. Menopause-related bone loss is greater in women with HIV, suggesting women with HIV may be at greater risk of osteoporotic fractures. HIV services should consider routine bone health assessment in midlife women as part of long-term HIV care delivery.

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Staging reproductive aging using Stages of Reproductive Aging Workshop + 10 in black urban African women in the Study of Women Entering and in Endocrine Transition

Cited by 19 publications

References 48 publications

Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection

Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

The Impact of Human Immunodeficiency Virus and Menopause on Bone Mineral Density: A Longitudinal Study of Urban-Dwelling South African Women

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