2019
DOI: 10.1093/ijnp/pyz053
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Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

Abstract: IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 fac… Show more

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Cited by 38 publications
(68 citation statements)
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References 136 publications
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“…Besides describing the most influential symptom domain of each stage, they also provided a timeline of the disorder. According to this timeline, stage 1 lasts about 3 years on average [25]. In this first stage, excitement and hostility symptoms were found to increase over time and becoming the leading symptom group of stage 2, that lasts Clinical Staging in Schizophrenia Spectrum Disorders DOI: http://dx.doi.org/10.5772/intechopen.98276 about 9 years on average [25].…”
Section: The Fountoulakis Staging Conceptmentioning
confidence: 90%
See 1 more Smart Citation
“…Besides describing the most influential symptom domain of each stage, they also provided a timeline of the disorder. According to this timeline, stage 1 lasts about 3 years on average [25]. In this first stage, excitement and hostility symptoms were found to increase over time and becoming the leading symptom group of stage 2, that lasts Clinical Staging in Schizophrenia Spectrum Disorders DOI: http://dx.doi.org/10.5772/intechopen.98276 about 9 years on average [25].…”
Section: The Fountoulakis Staging Conceptmentioning
confidence: 90%
“…A novel concept of clinical staging in schizophrenia was proposed by Fountoulakis and colleagues in 2019 using the Positive and Negative Syndrome Scale (PANSS) and the 5-factor model (a model based on the notion that schizophrenia is characterized by positive, negative, cognitive, affective and hostility symptoms) [25]. They aimed to develop a staging concept empirically through analyzing a very large sample (n = 2358) of stabilized schizophrenia patients with varying ages [25]. Based on the results, they identified 4 major stages of schizophrenia (Figure 8), starting with stage 1, dominated by positive symptoms.…”
Section: The Fountoulakis Staging Conceptmentioning
confidence: 99%
“…The factor scores for the subscales identified in our previous paper (positive [Po], negative [Ne], excitation/hostility [EH], depression and anxiety [DA], and neurocognitive impairment [Ncog]) have been used. 7…”
Section: Measurementsmentioning
confidence: 99%
“…The conclusion was that between centers, heterogeneity though present, had no impact on the results of that or the current study. 7…”
Section: Strengths and Limitations Of The Current Studymentioning
confidence: 99%
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