Stage of hepatocellular carcinoma is associated with periodontitis

Tamaki, Naofumi; Takaki, Akinobu; Tomofuji, Takaaki; Endo, Yoshikatsu; Kasuyama, Kenta; Ekuni, Daisuke; Yasunaka, Tetsuya; Yamamoto, Kazuhide; Morita, Manabu

doi:10.1111/j.1600-051x.2011.01777.x

Cited by 43 publications

(40 citation statements)

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“…Evidences have implicated that periodontal inflammation may be a potential risk factor for systemic diseases, including diabetes mellitus (14), cardiovascular disease (4), preterm low birth weight (17), chronic kidney diseases (1) and hepatocellular carcinoma (25). The mechanisms by which periodontitis affects these systemic diseases are still unclear.…”

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confidence: 99%

Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats

et al. 2011

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Gingival response to periodontal inflammation generates excessive lipid peroxide and such a condition may augment systemic health through increased circulating lipid peroxide. The purpose of the present study was to investigate whether the generation of lipid peroxide in periodontal inflammation could induce tissue injury in the liver, heart, kidney and brain using a rat model. Twelve Wistar rats (8 week-old male) were divided into 2 groups: the periodontal inflammation group, receiving topical application of lipopolysaccharide and proteases to the gingival sulcus for 4 weeks, and the control group using instead pyrogen-free water. After blood samples were collected, specimens from the brain, heart, liver and kidney were resected to determine the concentration of 8-hydroxydeoxyguanosine (an indicator of oxidative DNA damage). Gingival and serum levels for hexanoyl-lysine were measured to evaluate lipid peroxide. Administration of lipopolysaccharide and proteases induced periodontal inflammation, with increasing gingival and serum levels of hexanoyl-lysine. The level of 8-hydroxydeoxyguanosine increased 2.27, 2.01, 1.49 and 1.40 times in mitochondrial DNA from the liver, heart, kidney and brain of rats with periodontal inflammation, respectively. The results reveal that excessive production of lipid peroxide following periodontal inflammation is involved in oxidative DNA damage of the brain, heart, liver and kidney.

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Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats

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“…The results demonstrated that patients with HCC and periodontitis had higher JIS scores and circulating ROS levels compared with patients with HCC but without periodontitis (23). Therefore, the authors concluded that the stage of HCC may be associated with periodontitis, and increased ROS serum levels caused by periodontitis may be detrimental to hepatic health in patients with HCC (23). Another study proposed that inflammation may result in the migration of metastatic cells to the gingival soft tissues, as well as affecting where they invade, multiply and form a new tumor (26).…”

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confidence: 65%

“…The pathogenesis of the metastasis of malignant tumors to the gingiva is unclear. Following a comprehensive review of the literature, numerous studies were identified that discussed an association between HCC metastasis in particular and chronic periodontitis (20)(21)(22)(23). The patient in the present study had chronic periodontitis before the gingival tumor was observed.…”

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confidence: 89%

“…The results indicated that periodontitis may affect HCC by increasing the number of circulating ROS. Tamaki et al (23) recruited 64 patients with HCC, including 31 patients with chronic periodontitis and 33 periodontally healthy controls, and recorded the Japan Integrated Stage (JIS), which combines the tumor, lymph node, metastasis and Child-Turcotte-Pugh systems, and serum levels of reactive oxygen metabolites (ROM) in all patients. The results demonstrated that patients with HCC and periodontitis had higher JIS scores and circulating ROS levels compared with patients with HCC but without periodontitis (23).…”

Section: A B C Dmentioning

confidence: 99%

“…Tamaki et al (23) recruited 64 patients with HCC, including 31 patients with chronic periodontitis and 33 periodontally healthy controls, and recorded the Japan Integrated Stage (JIS), which combines the tumor, lymph node, metastasis and Child-Turcotte-Pugh systems, and serum levels of reactive oxygen metabolites (ROM) in all patients. The results demonstrated that patients with HCC and periodontitis had higher JIS scores and circulating ROS levels compared with patients with HCC but without periodontitis (23). Therefore, the authors concluded that the stage of HCC may be associated with periodontitis, and increased ROS serum levels caused by periodontitis may be detrimental to hepatic health in patients with HCC (23).…”

Section: A B C Dmentioning

confidence: 99%

See 2 more Smart Citations

Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature

Gong

Zhang

et al. 2015

Oncology Letters

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Abstract. Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a gingival tumor that was initially diagnosed as granulation tissue by a dental surgeon. Examination of the patient's medical history revealed that a solid mass, measuring 1.5 cm in diameter, was identified in the right lobe of the liver 2 years prior to presentation at the current hospital; however, no biopsy was performed. Thus, the tumor was resected and histological examination resulted in an initial diagnosis of atypical squamous cell carcinoma. However, the histopathological characteristics, immunohistochemical features and serum α-fetoprotein expression levels supported a diagnosis of metastatic HCC. In conclusion, the present case study highlights the difficulties in diagnosing metastatic HCC without a history of primary HCC, and the importance of excluding a diagnosis of metastatic tumor when a lesion is identified in the gingival. Furthermore, it was determined that a final diagnosis of gingival metastasis of HCC predominantly depends on pathological characteristics and immunohistochemical features.

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Effects of Periodontal Therapy on Circulating Oxidative Stress

Tomofuji

Ekuni

Morita

2013

Studies on Periodontal Disease

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Stage of hepatocellular carcinoma is associated with periodontitis

Abstract: HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

Cited by 43 publications

References 36 publications

Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats

Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats

Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature

Effects of Periodontal Therapy on Circulating Oxidative Stress

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