Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: An analysis of clinical outcomes and patterns of recurrence

Rasool, Nabila; Fader, Amanda N.; Seamon, Leigh G.; Neubauer, Nikki L.; Shahin, Fadi Abu; Alexander, Heather A.; Moore, Kathleen; Moxley, Katherine M.; Secord, Angeles Alvarez; Kunos, Charles; Rose, Peter G.; O’Malley, David M.

doi:10.1016/j.ygyno.2009.10.043

Cited by 44 publications

(28 citation statements)

References 19 publications

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“…The median number of para-aortic lymph nodes removed was 6 (range, 4-11) in the no lymph node dissemination group and 8.5 (range, [5][6][7][8][9][10][11][12][13][14][15][16] in the lymph node dissemination group (P = 0.002).…”

Section: Resultsmentioning

confidence: 99%

Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer

Solmaz

Mat

Dereli

et al. 2015

Aust NZ J Obst Gynaeco

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Section: Resultsmentioning

confidence: 99%

Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer

Solmaz

Mat

Dereli

et al. 2015

Aust NZ J Obst Gynaeco

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“…Creutzberg 42% in grade 3 stages IB and IC endometrial cancers versus 70% and 95% for grade 1Y2 stages IB and IC tumors, respectively. In a more recent large retrospective series, Rasool et al 24 reported an 11% recurrence rate for stage IB/IC grade 3 endometrioid endometrial carcinoma, which was predominantly located outside the pelvis.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Recurrence in Stage I Endometrioid Endometrial Adenocarcinoma With Lymphovascular Space Invasion

Simpkins

Papadia

Kunos

et al. 2013

Int J Gynecol Cancer

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Overall recurrence rates for stage IB-IIA EMCA patients with LVSI are high (23%). Although adjuvant radiation therapy improved pelvic control, it did not impact recurrence rates, cancer-related survival, and OS, likely secondary to distant failures. The role of systemic therapy with or without radiotherapy for early-stage EMCA with LVSI should be evaluated, particularly in patients with high-grade tumors or involvement of the LUS.

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“…This difference supports the hypothesis that G3 patients have a worse prognosis. Although the vaginal cuff is the most common site for tumor recurrence following a hysterectomy in early-stage endometrial carcinoma patients, with locoregional recurrence rates of 4-8% (8,15), Rasool et al (16) reported a high rate of distant recurrence in patients with stage I G3EEC and a risk of extra-pelvic recurrence of 80%, which is higher compared with local regional recurrence. In a previous study of 28 cases with stage IV G3EEC, recurrence was observed in 6 cases, and all of these were distant recurrence (17).…”

Section: A B Discussionmentioning

confidence: 99%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

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Abstract. The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ 2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local-regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high-risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.

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Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: An analysis of clinical outcomes and patterns of recurrence

Cited by 44 publications

References 19 publications

Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer

Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer

Patterns of Recurrence in Stage I Endometrioid Endometrial Adenocarcinoma With Lymphovascular Space Invasion

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

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