Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Abstract

Abstract. The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ 2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local-regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high-risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.

The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

“…There was no difference between age and DFS for 3 years in this study. This is consistent with the previous study which found no significant relationship for the influence of age on the incidence of recurrence in grade 3 endometrial cancer (13). Population of endometrioid type of high risk endometrial cancer with BMI <30 kg/m 2 is in accordance with data from Sanglah General Hospital, Indonesia regarding population from August 2012 to July 2014, which also received distribution of endometrial cancer based on body mass index between 18.5-22.9 kg/m 2 .…”

RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

“…With the development of novel anti-cancer therapies, survival of early stage EC has been significantly improved [15]. However, the therapeutic effects of advanced EC remain unsatisfactory owing to the lack of effective anti-cancer therapies [16]. As an alternative approach, accurate prognosis may improve patients' survival by guiding the selection of therapeutic approaches and care programs.…”

Risk factors for lymph node metastases in women with endometrial cancer: A population‐based, nation‐wide register study—On behalf of the Swedish Gynecological Cancer Group

“…Recent research has shown that evaluation of MI 1 LNM 5 number of women with lymph node metastasis/total LN 5 number of women who had lymph nodes removed. 2 Ungraded nonendometrioid tumors assigned Grade 3. 3 The effect of being one year older at diagnosis.…”

“…Lymph node metastasis (LNM) in endometrial cancer (EC) is a strong prognostic factor for survival. 1,2 However, there is no convincing evidence of the therapeutic benefit of systematic lymphadenectomy (LA) neither in presumed Stage I nor in higher stage disease. 3 Internationally, the use and the extent of LA in EC are debated and the guidelines for recommendations of surgical treatment vary between countries.…”