Stable PEG-coated silver nanoparticles – A comprehensive toxicological profile

Pînzaru, Iulia; Coricovac, Dorina; Dehelean, Cristina; Moacă, Elena-Alina; Mioc, Marius; Baderca, Flavia; Sizemore, Ioana E.; Brittle, Seth W.; Marti, Daniela; Calina, Daniela; Tsatsakis, Aristidis; Şoica, Codruţa

doi:10.1016/j.fct.2017.11.051

Cited by 126 publications

(90 citation statements)

References 66 publications

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“…In the present study at AgNPs (12 nm) concentration range 0.025-0.5 µ M cell viability and biomass biochemical composition was not affected significantly by the nanoparticles addition in the cultivation medium. Obtained data are in agreement with results presented by Pinzaru et al [32], who showed a lack of toxicity of AgNPs at concentrations lower than 10 μM. The lack of toxic effect of AgNPs to cells in present study can be explained by AgNPs coating with polyethylene glycol (PEG).…”

Section: Discussionsupporting

confidence: 93%

“…The lack of toxic effect of AgNPs to cells in present study can be explained by AgNPs coating with polyethylene glycol (PEG). In Bastos et al [33] and Pinzaru et al [32] studies it was shown that PEG-coated AgNPs showed a lesser degree of toxicity to HaCat cells as compared to bare AgNPs and NPs with other type of coating. At given concentrations AgNPs did not change or produce a slight increase of the proteins, carbohydrates, β-carotene and chlorophyll a content in spirulina biomass.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Peg-Coated Silver and Gold Nanoparticles on <em>Spirulina platensis</em> Biomass during Its Growth in Closed System

Cepoi¹,

Zinicovscaia²,

Rudi³

et al. 2020

Preprint

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Silver and gold nanoparticles are a promising tool for medical and industrial application, therefore, their ecotoxicity should be carefully examined. The effect of silver (12 nm) and gold (4.7) nanoparticles coated with polyethylene glycol on Spirulina platensis biomass growth and biochemical composition was investigated. The spirulina cultivation medium was supplemented with nanoparticles in concentration range 0.025-0.5 µ M. Given concentrations stimulated spirulina biomass growth, while content of proteins, carbohydrates and auxiliary pigments was affected insignificantly by presence of nanoparticles in cultivation medium. The pronounced effect of gold nanoparticles at concentration 0.5 µ M on the lipids content was observed. TEM images demonstrate that nanoparticles penetrate inside the cell, resulting in ultrastructural changes in cells.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of Peg-Coated Silver and Gold Nanoparticles on <em>Spirulina platensis</em> Biomass during Its Growth in Closed System

Cepoi¹,

Zinicovscaia²,

Rudi³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…PEG-CNT composites were found to be hemocompatible, nontoxic to mice fibroblast cell lines and effective as a drug carrier (Hindumathi, Jagannatham, Haridoss, & Sharma, 2018). for wound healing and targeted nanocarriers for skin pathologies and diagnostic applications (Meshram et al, 2018;Pinzaru et al, 2018). For a similar reason, PEG was also used to coat antimicrobial nanoparticles (such as silver, zinc, etc.)…”

Section: Polyethylene Glycolmentioning

confidence: 99%

“…For a similar reason, PEG was also used to coat antimicrobial nanoparticles (such as silver, zinc, etc.) for wound healing and targeted nanocarriers for skin pathologies and diagnostic applications (Meshram et al, 2018;Pinzaru et al, 2018). Hence, PEG is mainly used to coat novel materials for biomedical applications.…”

Section: Polyethylene Glycolmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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“…There are studies regarding * email:Vlazureanu@yahoo.com # Authors that contributed equally the toxicity of silver nanoparticles and samples with a spherical shape, and size between 10-50 nm are presented as a safe profile for healthy cells in terms of viability and in terms of acute/subacute toxicity on an animal model no denotive changes regarding health status after i.p. administration of low doses was observed [12]. Plants are an endless source of compounds with remarkable biological activity [13].…”

mentioning

confidence: 99%

Antimicrobial Activity and Cytotoxic Effect on Gingival Cells of Silver Nanoparticles Obtained by Biosynthesis

Andor¹,

Tischer²,

Berceanu-Văduva³

et al. 2019

Rev. Chim.

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The emergence and development of biofilm is steadily increasing and its currently used prevention and control schemes are free of unwanted effects. Silver nanoparticles obtained through biosynthesis represent an area of interest in the biofilm approach. In the present study, silver nanoparticles were obtained by using the aqueous extract of rosemary leaves which were subsequently tested for antimicrobial activity and for the influence regarding viability of healthy gingival cells. Experiments have shown a significant antimicrobial activity on E. coli, S. aureus, P. aeruginosa and C. albicans. The viability of keratinocytes and gingival fibroblasts was influenced by higher concentrations of test compound (10 and 25 �g/mL).

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Stable PEG-coated silver nanoparticles – A comprehensive toxicological profile

Cited by 126 publications

References 66 publications

Effect of Peg-Coated Silver and Gold Nanoparticles on <em>Spirulina platensis</em> Biomass during Its Growth in Closed System

Effect of Peg-Coated Silver and Gold Nanoparticles on <em>Spirulina platensis</em> Biomass during Its Growth in Closed System

Nanodiamond in composite: Biomedical application

Antimicrobial Activity and Cytotoxic Effect on Gingival Cells of Silver Nanoparticles Obtained by Biosynthesis

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