Stable Aqueous Dispersions of Glycopeptide‐Grafted Selectably Functionalized Magnetic Nanoparticles

Borase, Tushar; Ninjbadgar, Tsedev; Kapetanakis, Antonios; Roche, Sandra; O’Connor, Robert; Kerskens, Christian; Heise, Andreas; Brougham, Dermot F.

doi:10.1002/anie.201208099

Cited by 80 publications

(61 citation statements)

References 28 publications

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“…Progress in NCA polymerization has opened opportunities to synthesize a wealth of well-defined polypeptide structures [13][14][15]. As a result, polypeptides promise potential in biomedical fields such as drug delivery [16][17][18][19][20][21], tissue engineering [22] or imaging [23]. The synthesis of glycosylated polypeptides has been achieved using direct polymerization of glycosylated NCA or post-modification by conventional chemistry as well as click chemistry [24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Kapetanakis

Heise

2015

European Polymer Journal

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Kapetanakis

Heise

2015

European Polymer Journal

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“…Brougham et al [60] used surface-modified Fe 3 O 4 nanoparticles bearing primary amino groups as initiators for ROP of γ-propargyl-L-glutamate to prepare Fig. 30 Preparation of stable poly(L-glutamic acid) capsules using silica nanoparticles as template (Reprinted with permission from Harris et al [57].…”

Section: CLmentioning

confidence: 98%

Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures

Pahovnik

Hadjichristidis

2015

Anionic Polymerization

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Different synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for preparation of polypeptides with well-defined chain lengths and chain-end functionality are discussed. Recent examples from literature are used to illustrate different possibilities for synthesis of pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by modification of amino acids, before they are transformed into corresponding Ncarboxyanhydrides, or by post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for preparation of polypeptide-based hybrid materials are discussed as well using examples from recent literature. Syntheses of simple block copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as modifications of nanoparticles and other surfaces with polypeptides are described.

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“…[67] The magnetic particles were grafted with an alkyne functional polypeptide shell by polymerization of γ-propargyl glutamate NCA from APTES functional Fe 3 O 4 nanoparticles followed by copper catalyzed click reaction with azido galactose to introduce sugar functionality onto polypeptide shell ( Figure 3A). This approach produces biocompatible, colloidal stable, monodisperse, highly crystalline superparamagnetic MNPs that are suitable for T 1 -weighted MRI (Figure 3B,D).…”

Section: Research Newsmentioning

confidence: 99%

Hybrid Nanomaterials by Surface Grafting of Synthetic Polypeptides Using N‐Carboxyanhydride (NCA) Polymerization

Borase

Heise

2016

Advanced Materials

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The interaction of materials with their environment is largely dictated by interfacial phenomena. Polymers are very versatile materials to modulate material interfaces to provide functionality, stability and compatibility. A class of polymers that can close the gap between fully synthetic and natural macromolecules are polypeptides derived from N-carboxyanhydride (NCA) polymerization. Recent advances in using this technique to create biomimetic interfaces and hybrid materials are highlighted, with special emphasis on nanomaterials.

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Stable Aqueous Dispersions of Glycopeptide‐Grafted Selectably Functionalized Magnetic Nanoparticles

Cited by 80 publications

References 28 publications

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures

Hybrid Nanomaterials by Surface Grafting of Synthetic Polypeptides Using N‐Carboxyanhydride (NCA) Polymerization

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