Stable and Sensitive Electrochemical Detection of Phenolic Compounds at Carbon Nanotube Modified Glassy Carbon Electrodes

Wang, Joseph; Deo, Randhir P.; Musameh, Mustafa

doi:10.1002/elan.200302772

Cited by 98 publications

(63 citation statements)

References 13 publications

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“…Cyclic voltammograms of p-cresol in physiologically buffered sodium phosphate solution are shown in Figure 6. The bare gold surface (black) showed two oxidative waves near +500 and +735 mV vs. Ag/AgCl, similar to results published for electrochemical detection of p-cresol [10]. Oxidation of p-cresol on the nitrophenyl Au surface (red) showed a slightly reduced and positively shifted initial peak at +530 mV followed by an enhanced and negatively shifted peak at +710 mV.…”

Section: Resultssupporting

confidence: 81%

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Medically relevant ElectroNeedle technology development.

Schmidt¹,

Thomas²,

McClain³

et al. 2008

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ElectroNeedles technology was developed as part of an earlier Grand Challenge effort on Bio-Micro Fuel Cell project. During this earlier work, the fabrication of the ElectroNeedles was accomplished along with proof-of-concept work on several electrochemically active analytes such as glucose, quinone and ferricyanide. Additionally, earlier work demonstrated technology potential in the field of immunosensors by specifically detecting Troponin, a cardiac biomarker. The current work focused upon fabrication process reproducibility of the ElectroNeedles and then using the devices to sensitively detect p-cresol, a biomarker for kidney failure or nephrotoxicity. Valuable lessons were learned regarding fabrication assurance and quality. The detection of p-cresol was accomplished by electrochemistry as well as using fluorescence to benchmark ElectroNeedles performance. Results from these studies will serve as a guide for the future fabrication processes involving ElectroNeedles as well as provide the groundwork necessary to expand technology applications. One paper has been accepted for publication acknowledging LDRD funding (K. E. Achyuthan et al, Comb. Chem. & HTS, 2008). We are exploring the scope for a second paper describing the applications potential of this technology.

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Section: Resultssupporting

confidence: 81%

“…Effective electrochemical detection of p-cresol on carbon nanotube (CNT) modified glassy carbon electrodes (GCE) that resist passivation has been reported [10]. We therefore investigated methods for obtaining robust conducting thin films on Au surfaces with properties similar to those of carbon nanotubes.…”

Section: Resultsmentioning

confidence: 99%

Medically relevant ElectroNeedle technology development.

Schmidt¹,

Thomas²,

McClain³

et al. 2008

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“…Recently, the use of carbon nanotubes electrodes proved to resolve these fouling problems [12], but their relatively cost and delicate handling, discourage their suitability for routinely applications. Since the most important aspect of the present work is its simplicity, low handling, low cost and low time consumption, we minimized the drift caused by phenols with different synergic ways.…”

Section: Resultsmentioning

confidence: 99%

Amperometric Electronic Tongue for the Evaluation of the Tea Astringency

et al. 2006

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A new multi-flow-through amperometric detectors design was employed as a sensors array system for the detection of flavor related phenols. Relevant parameters of the amperometric detection were examined and optimized. The multivariate analytical signal was processed with chemometric analysis for exploring and classifying the tea beverages. Multivariate regression was used to correlate the astringency value of several tea beverages, obtained by the UNI (Italian Organization for Standardization) sensory profile test, with the signals collected by this amperometric electronic tongue.

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“…Carbon nanotubes have remarkable electrical properties, such as high specific surface area and chemical stability [28][29][30], and can be used as electrode material to promote electron transfer between electroactive species and the electrode. Addition of CNT to conducting polymer, such as PEDOT, results in a significant increase in the mechanical properties and enhances electrical properties of the polymer by facilitating the charge transfer processes.…”

Section: Isrn Analytical Chemistrymentioning

confidence: 99%

Determination of Phenol and Chlorophenols at Single-Wall Carbon Nanotubes/Poly(3,4-ethylenedioxythiophene) Modified Glassy Carbon Electrode Using Flow Injection Amperometry

Negash

Alemu

Tessema

2014

ISRN Analytical Chemistry

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Phenol and chlorophenols were investigated using single-wall carbon nanotubes (SWCNT) and poly(3,4-ethylenedioxythiophene) (PEDOT) composite modified glassy carbon electrode (SWCNT/PEDOT/GCE) as a detector in flow injection system. Optimization of experimental variables such as the detection potential, flow rate, and pH of the carrier solution (0.1 M sodium acetate) for the determination of phenol (P), 4-chlorophenol (CP), 2,4-dichlorophenol (DCP), 2,4,6-trichlorophenol (TCP), and pentachlorophenol (PCP) were performed. Under these conditions, analytical parameters were calculated from the calibration curve of measured amperometric responses as a function of concentrations of phenol and chlorophenols. The designed electrode exhibited very good analytical performance. The designed electrode was tested with 20 repetitive injections of each analyte and showed good operational stability. The analytical performance of the SWCNT/PEDOT/GCE electrode under flow through conditions was tested and was found to be impressive. The electrode showed a wider dynamic range for the detection of phenol and chlorophenols with low limits of detection compared with other enzymatic and nonenzymatic sensors. These results suggest that the method is quite useful for the analysis and monitoring of phenols and chlorophenols.

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Stable and Sensitive Electrochemical Detection of Phenolic Compounds at Carbon Nanotube Modified Glassy Carbon Electrodes

Cited by 98 publications

References 13 publications

Medically relevant ElectroNeedle technology development.

Medically relevant ElectroNeedle technology development.

Amperometric Electronic Tongue for the Evaluation of the Tea Astringency

Determination of Phenol and Chlorophenols at Single-Wall Carbon Nanotubes/Poly(3,4-ethylenedioxythiophene) Modified Glassy Carbon Electrode Using Flow Injection Amperometry

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