ElectroNeedles technology was developed as part of an earlier Grand Challenge effort on Bio-Micro Fuel Cell project. During this earlier work, the fabrication of the ElectroNeedles was accomplished along with proof-of-concept work on several electrochemically active analytes such as glucose, quinone and ferricyanide. Additionally, earlier work demonstrated technology potential in the field of immunosensors by specifically detecting Troponin, a cardiac biomarker. The current work focused upon fabrication process reproducibility of the ElectroNeedles and then using the devices to sensitively detect p-cresol, a biomarker for kidney failure or nephrotoxicity. Valuable lessons were learned regarding fabrication assurance and quality. The detection of p-cresol was accomplished by electrochemistry as well as using fluorescence to benchmark ElectroNeedles performance. Results from these studies will serve as a guide for the future fabrication processes involving ElectroNeedles as well as provide the groundwork necessary to expand technology applications. One paper has been accepted for publication acknowledging LDRD funding (K. E. Achyuthan et al, Comb. Chem. & HTS, 2008). We are exploring the scope for a second paper describing the applications potential of this technology.
Executive SummaryThis LDRD was conceived to develop a power system that could harvest the energy from carbohydrate fuels that are readily available and can be harvested from biological sources. This included the possibilities of generating power from harvested tree sap, sugars, and even mammalian blood. Since the biological host continues to produce and/or replace these fuels as part its normal biological processes, this approach enables a very long lived, power microsystem. Fuel cells were identified as the energy conversion systems most likely to take advantage of the opportunities of a continuous fuel supply, and therefore the project started from an existing foundation in traditional fuel cell operations.Six basic subtasks were identified for this project; harvesting, membrane separation, catalysis, architecture, enzymology, and power management. Harvesting targeted both harvesting from a tree using a simple spile arrangement, and harvesting through the skin of mammalian hosts using a microneedle patch. Membrane separation provided a physical separator between the anode oxidation of the fuel and the cathodic reduction of oxygen. The catalysis team targeted both the development of new, poison resistant, highly active noble metal catalysts that could readily oxidize the carbohydrate fuel without poisoning the catalysts, and also worked to develop mediator molecules to transport oxidized electrons from enzyme catalysts to anode electrode surfaces. The enzymology team developed protocols for the genetic engineering of enzymes capable of oxidizing the carbohydrates, and also looked into the requirements to immobilize these enzymes against an electrode, together with the catalysis team. The architecture team was tasked with developing a small architecture that could take in these other components and assemble them into working fuel cells running on glucose (a simple carbohydrate) and oxygen. The power management task, added after the initial program was started, focused on handling the variation in the power output from the fuel cells and in turn producing stable, electronic grade power to supply to an external circuit.At the end of the project, the best power generated from a single, 15mm x 21mm x 1mm fuel cell was about 7 mW/cm 2 running on 1 molar (M) glucose in water and oxygen at room temperature. This was achieved using a noble metal catalyst. The best enzymatic fuel cell using an anode based on glucose oxidase was able to demonstrate 5 250μW/cm 2 of power from a 50 millimolar glucose solution. In both cases, however, the lifetime was limited to a few minutes . In the noble metal case, oxidation byproducts quickly poison the catalysts. However, a system solution for in situ cleaning of the anode with little power penalty eventually extending the lifetime to about 700 hours (nearly one month) while producing about 2 mW/cm 2 . In the enzymatic case, the lifetime was limited to minutes of operation by the loss of enzyme and mediator to the flowing fuel.Significant progress was made in stabilizing the enzyme, bu...
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The most singular focus of the electronics industry during the last 50 years has been to miniaturize ICs by miniaturization of transistors and on-chip interconnections. Two major problems are foreseen with this approach; (1) electrical leakage and (2) the lack of improved electrical performance beyond 16nm. As a result, the industry is transitioning from the current SOC-based approach to a through-silicon-via (TSV) based 3D IC-stacked approach. However, a major challenge remains; these 3D ICs need to be interconnected to other ICs with a much higher number of I/Os than are available with current ceramic or organic interposers. While silicon interposers currently in development can provide these high I/Os, they cannot do so at low enough cost. In this extended abstract, 3D Glass Solutions, a division of Life BioScience, Inc., presents our efforts in glass interposer microfabrication. Glass interposers possess many advantages over silicon interposers including: cost, production time, and scale. 3D Glass Solution’s APEX™ Glass ceramic is a photo-sensitive material used to create high density arrays of through glass vias (TGVs) using three simple processing steps: exposure, baking, and etching. To date, we have been successful in producing large arrays of 12 micron diameter TGVs, with 14 micron center-to-center pitch, in 125 micron thick APEX™ Glass ceramic. This extended abstract covers (1) on our efforts producing high aspect ratio TGVs in ultra thin (75–250 micron) APEX™ Glass ceramic wafers, (2) maximum TGV aspect ratios, and (3) TGV fidelity and limits of manufacturing.
The push for heterogeneous integration requires very unique material properties with respect to processing, material constants, and integration capabilities with other materials (such as copper, III–V, magnetics, etc.). Current common circuit board materials such as ceramics and laminates, as well as silicon substrates, suffer from a variety of limitations. For ceramics and laminates, these constraints include: (1) the inability to produce narrow line widths <100 m with narrow gaps between lines <100 m; (2) high surface roughness (on the order of 2μm RMS); (3) layer-to-layer misalignments; and (4) lack of high-quality integrated passives. For silicon, these constraints include: (1) high cost; (2) long design/production lead times; and (3) electrical properties of standard doped silicon are not suitable for millimeter-wave applications. A significant drawback of ceramics and laminates is that they cannot be 3D structured with micron-scale precision which is necessary for advanced interconnects for millimeter-wave IC packaging integration (e.g. transistor-to-board interconnects). These characteristics lead to devices with limited integration options, large footprints, and higher power consumption. To overcome the above limitations, 3D Glass Solutions (3DGS) has developed a photo-sensitive glass ceramics as a board-level system substrate. Compared to ceramics, laminates, and silicon, photo-sensitive glass ceramic materials offer higher interconnect densities, lower processing cost, better spatial resolution, as well as improved electrical properties for both RF and millimeter-wave frequencies. Photo-sensitive glass ceramics are ideal systems-level materials for heterogeneous integration programs as they overcome many of the limitations of legacy materials such as ceramics and laminates for broadband applications (DC – 100GHz). Furthermore, the advanced manufacturing ability of photo-sensitive glass ceramics enable a broad category of IP Blocks. The innovations of the 3DGS technology and research effort include:Low loss and low dispersion: photosensitive glass material has a measured loss tangent of 0.008 at GHz frequencies. Furthermore, the thick and highly-conductive metallization layers allow for low-loss transmission lines.High current and power handling: the metallization processes enable lines with a range of thicknesses (<50m) and widths (>2m), which result in both low resistive loss and high current handling. Additionally, the RF power handling is high due to the high breakdown voltage of glass (10kV/100m) and the possibility of coaxial line integration.Thermal management: high-density metal-filled via arrays generate up to 100W/mK thermal transfer in the 3DGS process and provide an additional thermal path for chips that are not mounted directly on a heterogeneous interface heat spreader.Built-in filtering: when a variety of chiplets with unknown design parameters and with signals of varying time constants are interconnected, EMI becomes a significant problem. The 3DGS approach allows for high-quality filtering, coupling and self-assessment functions to be directly integrated within the 2.5D interposer system as IPDs eliminating wire bonding and providing seamless integration with low loss.Scalability: the glass interconnect plane can be fabricated with footprints up to 40mm × 40mm with integrated air cavities for chip placement, through glass vias for I/Os and redistribution metal. In this presentation, 3DGS will present on three Heterogeneous Integration attributes: (1) design considerations, (2) integration of passive devices, and (3) millimeter wave integration. Design Considerations 3DGS is developing an IP Block library with 11 distinct categories. These categories include: (1) metal filled I/Os, (2) copper redistribution layers, (3) thermal management blocks, (4) cavities, (5) metal filled through glass structures, (6) phased array antenna, (7) conductor undercuts, (8) magnetic core devices, (9) capacitors, (10) inductors, and (11) grounding. While each of these unique IP Blocks contributes their own advantages for analog performance, they can all be integrated into a single chip. Integration of Passives Devices The foundation of the work done by 3DGS is on developing a volume manufacturing approach for high uniformity through glass vias (TGVs). All TGVs for I/O applications are 100% copper filled for low-loss, high power, electrical connections. Two major building blocks of 3DGS' Heterogeneous technology are High Quality Factor inductors and capacitors. 3DGS has developed a broad library of inductor components ranging from 0.5 – 200nH. Footprints are determined by inductance sizes but may be as small as 01005. Capacitors are built by placing two slots inside of the glass material, filling the slots with copper, and using the glass' natural Dk to form a capacitor. The benefit of these capacitors include high breakdown voltage (>1,000V), small footprint, high reliability, and Quality factors between 200–300. Inductors and capacitors can be integrated into a single monolithic RF package called an Integrated Passive Device (IPD). The benefits of the IPD include the elimination of RF losses associated with PCB Interconnects, long metal redistribution line lengths, bond pads, solder balls, and inconsistent assembly. This leads to the production of RF devices, capable of operating in the MHz – GHz frequency range with higher overall system Quality Factors, lower ripple, and lower losses. Furthermore, IPDs can be directly integrated into more complex System-in-Package (SiP) architectures. This approach has been used to build an RF ZigBee module in APEX® Glass [1]. The glass SiP module consisted of 35+ SMT components and was itself soldered to a PCB board. The full RF module was then subjected full complement of reliability tests and met the customer's stringent performance goals. Millimeter Wave Integration A major benefit of glass is the ability to produce low loss structures for millimeter wave applications. 3DGS has been designing and producing a variety of millimeter wave band pass filters with a variety of bandwidths ranging from 5–40%. These bandpass filters are compact, fully shielded and low loss (<2.0dB) with high attenuation (>50dB).
Interposer technologies are gathering more importance in IC packaging as the industry continues miniaturization trends in microfabrication nodes and IC packaging to meet design and utility needs in consumer electronics. Furthermore, IC packaging is widely seen as a method to prolong Moore's law. Historically, silicon has been the material of interest for interposer materials given its prevalence in IC production, but it presents many technical and costs hurdles. In contrast, glass interposer technology presents a low cost alternative, yet attempts at producing advanced through glass vias (TGVs) arrays using traditional methods, such as laser ablation, have inherent process flaws, such as reduced interposer mechanical strength and debris sputtering among others. In this extended abstract we present 3D Glass Solutions' efforts in using our proprietary APEX™ Glass ceramic to create various interposer technologies. This extended abstract will present on the production of large arrays of 10 micron diameter TGVs, with 20 micron center-to-center pitch, in 100 micron thick APEX™ Glass ceramic and the comparisons of wet etching of APEX™ Glass vs. laser ablation.
The objective is a significant advancement in the state-of-the-art of accelerometer design for tactical grade (or better) applications. The design goals are <1 milli-G bias stability across environments and $200 cost. This quantum leap in performance improvement and cost reduction can only be achieved by a radical new approach, not incremental improvements to existing concepts. This novel levitated closed-loop accelerometer is implemented as a hybrid micromachine. The hybrid approach frees the designer from the limitations of any given monolithic process and dramatically expands the available design space. The design can be tailored to the dynamic range, resolution, bandwidth, and environmental requirements of the application while still preserving all of the benefits of monolithic MEMS fabrication -extreme precision, small size, low cost, and low power.
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