Stabilized Cu2O nanoparticles on rGO highly catalyzed direct oxidative coupling synthesis of α-ketoamides with molecular oxygen

Lu, Weiyang; Sun, Wei; Tan, Xiaofeng; Wang, Bin; Yang, Hua; Gao, Lingfeng; Zheng, Gengxiu

doi:10.1016/j.catcom.2019.105806

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…3B), two broad and asymmetrical peaks were identified in the Cu 2p region. It confirmed a mixed-valence state of Cu species in CuO x /CF-3 [43,44], consistent with the XRD results. Additionally, the existence of Cu 2+ and Cu + was further identified from the Cu LM2 X-ray excited Auger spectroscopy of CuO x /CF-3, as depicted in Fig.…”

Section: Morphology Phase and Surface Chemical Statessupporting

confidence: 89%

Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction: Synthesis, kinetics, and mechanisms

Geng

An²,

Wang³

et al. 2022

Journal of Environmental Chemical Engineering

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Section: Morphology Phase and Surface Chemical Statessupporting

confidence: 89%

Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction: Synthesis, kinetics, and mechanisms

Geng

An²,

Wang³

et al. 2022

Journal of Environmental Chemical Engineering

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“…These consequences could indicate that the surface Cu 2+ species was developed by the oxidation of CuO NPs in the air. [34,35] Furthermore, the changes in the Zeta potential and particle size distribution of eventual CO-MX NCs were demonstrated by the DLS measurements. Compared with the TC-MX NSs (−35 mV, Figure 1F), the surface potential of CO-MX NCs was significantly reduced due to the positively charged Cu 2 O nanoparticles on the surface and the oxidized Cu 2+ (Figure 3D).…”

Section: Characterization Of Co-mx Ncsmentioning

confidence: 94%

“…These peaks could be applied to calculate the ratio of Cu + to Cu 2+ content as ≈1:1. [34] Meanwhile, no CuO crystal plane diffraction peak in the XRD spectrum of CO-MX NCs was evident. These consequences could indicate that the surface Cu 2+ species was developed by the oxidation of CuO NPs in the air.…”

Section: Characterization Of Co-mx Ncsmentioning

confidence: 99%

Transition Metal Oxide‐Decorated MXenes as Drugless Nanoarchitectonics for Enriched Nanocatalytic Chemodynamic Treatment

Xia,

Li,

et al. 2024

Adv Healthcare Materials

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Despite their unique characteristics, the recently emerged two‐dimensional (2D) MXenes with sole photothermal conversion ability are required to explore their superfluous abilities in biomedicine. To this end, small‐molecule‐based chemotherapeutics suffer from various shortcomings of time‐consuming and expensiveness in terms of molecular docking and subsequent mechanistic (preclinical/clinical) performance checks, hampering their full potential of precisely eradicating diseases. This study demonstrates the fabrication of Ti3C2 MXene nanosheets (TC‐MX NSs) and decoration with transition metal oxides, i.e., copper oxide (Cu2O/MX, shortly denoted as CO‐MX NCs) as drugless nanoarchitectonics for synergistic photothermal (PTT)‐chemodynamic therapeutic (CDT) efficacies. Initially, the monolayer/few‐layered TC‐MX NSs are prepared using the chemical etching‐assisted ultrasonic exfoliation method and then deposited with Cu2O nanoconstructs using the in situ reduction method. Further, the photothermal ablation under near‐infrared (NIR)‐II laser irradiation evidently showed mild PTT effects of CO‐MX NCs. The deposited Cu2O on TC‐MX NSs facilitated the release of copper (Cu+) ions in the acidic microenvironment intracellularly for Fenton‐like reaction‐assisted CDT effects and enriched PTT effects synergistically. Mechanistically, these deadly free radicals intracellularly imbalanced the glutathione (GSH) levels and subsequently resulted in mitochondrial dysfunction, inducing apoptosis of 4T1 cells. Finally, the in vivo investigations in BALB/c mice confirmed the substantial therapeutic effects of ablating breast carcinoma. Together, these findings demonstrated the potential synergistic photothermal‐chemodynamic therapeutic effects of the designed CO‐MX NCs as drugless nanoarchitectonics against breast carcinoma.This article is protected by copyright. All rights reserved

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“…The α-ketoamides 54 were synthesized from acetophenones 19 and secondary amines 53 using Cu2O nanoparticle in presence of oxygen and NIS (N-iodosuccinimide) at room temperature (Scheme 13). [41] The nano particles were recycled successfully. This protocol for synthesis of α-ketoamide derivatives displayed broad substrate scope which involves several electron rich/deficient aryl ketones and various secondary amines.…”

Section: Scheme 11 Synthetic Route For the α-Ketoamides 44mentioning

confidence: 99%

A concise review on copper catalyzed synthesis of α-ketoamides

Swain,

Gautam

2024

Preprint

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The α-keto-amides are essential building blocks for the synthesis of β-lactams and oxazolidinones. As it contains multiple reactive centers, it could be a suitable starting material for following reactions such as Michael addition reaction, Pictet–Spengler reaction, Mannich, Stetter reaction etc. There are many US FDA approved drug molecules which bear α-keto amid moieties, such as boceprevir, telaprevir, fostemsavir, varespladib etc. Copper-catalyzed synthesis of α-ketoamides from acetophenones, aryl acetic acids, alkynes, aryl acetaldehydes, α-keto acids, α-azido ketones, and 1,3-diketo compounds have been reported. This review describes the research articles (since the year 2012) related copper-catalyzed α-keto amides synthesis and mechanism of those reactions.

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Stabilized Cu2O nanoparticles on rGO highly catalyzed direct oxidative coupling synthesis of α-ketoamides with molecular oxygen

Cited by 9 publications

References 35 publications

Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction: Synthesis, kinetics, and mechanisms

Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction: Synthesis, kinetics, and mechanisms

Transition Metal Oxide‐Decorated MXenes as Drugless Nanoarchitectonics for Enriched Nanocatalytic Chemodynamic Treatment

A concise review on copper catalyzed synthesis of α-ketoamides

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