Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential

Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

“…Similarly, nutritional status is another factor that influences telomere length [284]. For example, the long-term supplementation of foods that are rich in omega-3 (n-3) polyunsaturated fatty acids (PUFA) [285], vitamins such as vitamin A [286], B or folate [287], C, E [288], and D [289], carotenoids such as lutein and zeaxanthin [290,291], polyphenols [292], fiber [293], greater adherence to the Mediterranean diet, or a diet rich in vegetables and fruits (whole grains, nuts, tea, coffee, and legumes) or consumption of eggs, fish, seaweed, minerals such as copper, iron, magnesium, and calcium [294][295][296][297], delay the shortening of the TL in older adults through glycated hemoglobin (HbA1c) [284,288]. These effects are mainly attributable to the overexpression of endogenous antioxidants that cause a decrease in OxS and mitochondrial dysfunction [298] or they are also attributable to its anti-inflammatory properties [299].…”

Elderberry (Sambucus nigra L.) juice as a novel functional product rich in health-promoting compounds

“…Numerous studies are based on the examination of the antioxidant potential of wild-growing plants in order to regulate metabolic processes. 5 In addition to the antioxidant potential, researches on various plant species also aim to examine the regulation of enzyme overactivity.…”

Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

“…Polyphenol-rich diets are strong antioxidants that function in vitro and in vivo. Polyphenol compounds such as resveratrol, quercetin, and curcumin have a defensive role against oxidative stress injuries [86,87].…”

“…Levels of oxidative stress, antioxidants, mitochondrial alteration, inflammation, shortening of telomeres, and gene mutations all have a critical role in defining cellular aging. Studies propose that oxidative stress and the free radicals formed by it play an indispensable role in telomere shortening through reducing the action of telomerase or telomeric repeat-binding factor 2 (TRF-2) levels [87]. Shortening the telomere length harms health and leads to genomic variability and consequently jeopardizes the function of the cell cycle, and the cells enter the aging and apoptotic phases [87,109].…”

“…Therefore, studies propose that polyphenols, with their antioxidant and anti-inflammatory abilities, can affect telomere length and prevent shortening as far as probable and thus have powerful anti-aging capabilities [87].…”