Stabilization of Antitumor Agent Busulfan through Encapsulation within a Water‐Soluble Pillar[5]arene

Abstract

The complexation of the antitumor agent busulfan by negatively charged carboxylatopillar[5]arene in water is reported. The encapsulation within carboxylatopillar[5]arene reduces the hydrolytic degradation of busulfan from 90.7% to 25.2% after 24 days and accordingly enhances its stability by providing a hydrophobic shelter for busulfan in water. Moreover, the complexation results in 12 times improvement of water solubility for busulfan. Our result provides a supramolecular approach for stabilizing the anticancer agent busulfan.

Pillar[5]arene-Derived Terpyridinepalladium(II) Complex: Synthesis, Characterization, and Application in Green Catalysis

“…They were first prepared by Ogoshi et al in 2008 through methylene-bridged 1,4-dimethoxybenzene . Compared with crown ethers and calixarenes, the molecular symmetry and rigidity of pillar[5]arene are better, while in contrast with cucurbiturils and cyclodextrins, pillar[5]arenes are easier to functionalize on their frameworks Soon after their syntheses, different types of pillar[5]arenes, such as monofunctionalized pillar[5]arenes, difunctionalized pillar[5]arenes, perfunctionalized pillar[5]arenes, phenylene-substituted pillar[5]arenes, pillar[5]arene dimers, and rim-differentiated pillar[5]arenes, have been designed and prepared successfully . Up to now, pillar[5]arenes have been widely applied in various fields, such as controlled drug release/cancer therapy, catalysis, molecular separation/purification, light harvesting, detection, and stabilization of metal nanoparticles …”