Stability of the seven hexon hypervariable region sequences of adenovirus types 1–6 isolated in Yamagata, Japan between 1988 and 2007

Mizuta, Katsumi; Matsuzaki, Yoko; Hongō, Seiji; Ohmi, Akira; Okamoto, Michiko; Nishimura, Hidekazu; Itagaki, Tsutomu; Katsushima, Noriko; Oshitani, Hitoshi; Suzuki, Akira; Furuse, Yuki; Noda, Masahiro; Kimura, Hirokazu; Ahiko, Tadayuki

doi:10.1016/j.virusres.2008.10.014

Cited by 21 publications

(20 citation statements)

References 28 publications

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“…Several molecular epidemiology studies found that the HAdV-3 hexon sequences have a high variability mainly in the HVRs, including HVR1, HVR3, HVR6, and HVR7, and that they have formed multiple genetic lineages (Mahadevan et al, 2010;Choi et al, 2006;Fujimoto et al, 2008;Mizuta et al, 2009;Biere and Schweiger, 2010). Our results using the globally known HAdV-3 hexon sequences available in GenBank (Fig.…”

Section: Antiserumsupporting

confidence: 49%

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

Tian

Liu

et al. 2015

Virus Research

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Section: Antiserumsupporting

confidence: 49%

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

Tian

Liu

et al. 2015

Virus Research

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“…A recent report on Japanese isolates includes data that are in part congruent with our observations, but not all amino acid changes are identical. 22 However, the Japanese isolates of serotype 5 also form two clusters in phylogenetic analyses, but a separation of serotype 2 in different genetic lineages was not clearly demonstrated. For both serotypes, the distinction of genetic lineages can phylogenetically be verified by the inclusion of database sequences into our data set.…”

Section: Discussionmentioning

confidence: 96%

Human adenoviruses in respiratory infections: Sequencing of the hexon hypervariable region reveals high sequence variability

Biere

Schweiger

2010

Journal of Clinical Virology

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“…Ads display seven hypervariable region (HVR) domains on their hexon proteins that vary in sequence between serotypes [52] and are primary targets for neutralizing antibodies [53, 54]. Variations in these HVRs appear to correlate with FX binding affinity and with the ability of Ad serotypes to transduce hepatocytes [47].…”

Section: Adenovirus Pharmacology In Vivomentioning

confidence: 99%

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

Khare

Chen

Weaver³

et al. 2011

CGT

129

138

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Adenovirus is a robust vector for therapeutic applications, but its use is limited by our understanding of its complex in vivo pharmacology. In this review we describe the necessity of identifying its natural, widespread, and multifaceted interactions with the host since this information will be crucial for efficiently redirecting virus into target cells. In the rational design of vectors, the notion of overcoming a sequence of viral “sinks” must be combined with re-targeting to target populations with capsid as well as shielding the vectors from pre-existing or toxic immune responses. It must also be noted that most known adenoviral pharmacology is deduced from the most commonly used serotypes, Ad5 and Ad2. However, these serotypes may not represent all adenoviruses, and may not even represent the most useful vectors for all purposes. Chimeras between Ad serotypes may become useful in engineering vectors that can selectively evade substantial viral traps, such as Kupffer cells, while retaining the robust qualities of Ad5. Similarly, vectorizing other Ad serotypes may become useful in avoiding immunity against Ad5 altogether. Taken together, this research on basic adenovirus biology will be necessary in developing vectors that interact more strategically with the host for the most optimal therapeutic effect.

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Stability of the seven hexon hypervariable region sequences of adenovirus types 1–6 isolated in Yamagata, Japan between 1988 and 2007

Cited by 21 publications

References 28 publications

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

Human adenoviruses in respiratory infections: Sequencing of the hexon hypervariable region reveals high sequence variability

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

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