Stability of Solids and Solid Dosage Forms

Carstensen, J.T.

doi:10.1002/jps.2600630103

Cited by 159 publications

(68 citation statements)

References 91 publications

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“…Já sendo conhecido o perfi l higroscópico, em umidade relativa de 60 e 90 % para os extratos secos contendo 30 % de Aerosil (Figura 1 e 2), para a otimização dos parâmetros de secagem utilizou-se apenas o estudo da manutenção das características físicas frente à umidade relativa de 90 %. Conforme mostra a fi gura 5, o ganho de massa dos extratos secos, mostrou um crescimento brusco nas primeiras 24 horas de exposição à atmosfera de 90 % UR, seguindo uma tendência a um platô para os demais dias de exposição, sugerindo haver um equilíbrio entre a pressão de vapor do material em análise e a pressão de vapor da água da atmosfera, independente dos parâmetros da concentração de Aerosil e da temperatura de secagem (Carstensen, 1976). Quanto aos aspectos físicos dos pós-secos, observou-se comportamentos diferentes.…”

Section: Otimização Da Temperatura De Secagem E Concentração De Aerosilunclassified

Influência da temperatura de secagem e da concentração de Aerosil®200 nas características dos extratos secos por aspersão da Schinus terebinthifolius Raddi (Anacardiaceae)

Vasconcelos¹,

Medeiros²,

Raffin³

et al. 2005

Rev. bras. farmacogn.

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Section: Otimização Da Temperatura De Secagem E Concentração De Aerosilunclassified

Influência da temperatura de secagem e da concentração de Aerosil®200 nas características dos extratos secos por aspersão da Schinus terebinthifolius Raddi (Anacardiaceae)

Vasconcelos¹,

Medeiros²,

Raffin³

et al. 2005

Rev. bras. farmacogn.

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“…Chemical degradation of prazosin salts was high initially, but slowed down subsequently. This could be attributed to the initial surface photodegradation and (27,28). An additional contributor could be the shielding of bulk material by colored photodegradation products formed on the surface (27).…”

Section: Photodegradation Of Prazosin Saltsmentioning

confidence: 99%

“…This could be attributed to the initial surface photodegradation and (27,28). An additional contributor could be the shielding of bulk material by colored photodegradation products formed on the surface (27). In contrast, lesser surface discoloration was observed in PRB HCl AN, thus providing weaker shielding of bulk molecules.…”

Section: Photodegradation Of Prazosin Saltsmentioning

confidence: 99%

Effect of Counterion on the Solid State Photodegradation Behavior of Prazosin Salts

Kumar

Jog²,

Singh³

et al. 2013

AAPS PharmSciTech

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Abstract. The effect of counterion was evaluated on the photodegradation behavior of six prazosin salts, viz., prazosin hydrochloride anhydrous, prazosin hydrochloride polyhydrate, prazosin tosylate anhydrous, prazosin tosylate monohydrate, prazosin oxalate dihydrate, and prazosin camsylate anhydrous. The salts were subjected to UV-Visible irradiation in a photostability test chamber for 10 days. The samples were analyzed for chemical changes by a specific stability-indicating high-performance liquid chromatography method. pH of the microenvironment was determined in 10%w/v aqueous slurry of the salts. The observed order of photostability was: prazosin hydrochloride anhydrous>prazosin camsylate anhydrous∼prazosin-free base>prazosin hydrochloride polyhydrate>prazosin tosylate anhydrous>prazosin oxalate dihydrate∼prazosin tosylate monohydrate. Multivariate analysis of the photodegradation behavior suggested predominant contribution of the state of hydration and also intrinsic photosensitivity of the counterion. Overall, hydrated salts showed higher photodegradation compared to their anhydrous counterparts. Within the anhydrous salts, aromatic and carbonyl counterion-containing salts showed higher susceptibility to light. The pH of microenvironment furthermore contributed to photodegradation of prazosin salts, especially for drug counterions with inherent higher pH. The study reveals importance of selection of a suitable drug salt form for photosensitive drugs during preformulation stage of drug development.

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“…The presence of starch in a Methocel K15 MCR matrix tablet could modify the release rate, due to the disintegration phenomenon is based on the fast water uptake, followed by the Methocel K15 MCR swelling [15]. Thus, the comparative influence of the co-excipients starch and MCC as release modifiers was evaluated.…”

Section: Effect Of Starchmentioning

confidence: 99%

In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices

Rahman¹,

Islam²,

Wahed³

et al. 2009

J. Sci. Res.

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Methocel K15 MCR (a modified hydroxypropylmethylcellulose) matrix tablets of pentoxifylline using microcrystalline cellulose (MCC), starch and lactose were prepared by wet granulation process. There was no significant difference in drug release between the hydrophilic matrices when the Methocel K15 MCR concentration was modified in low percentage. The release of pentoxifylline was influenced by the presence of microcrystalline cellulose, and by the different concentrations of starch and lactose. The data obtained proved that the formulation with 12.5% Methocel K15 MCR and 20% lactose is more useful for a controlled release pentoxifylline, due to the percentage released after 8 hours is nearly to 65%. There was no significant change on release profile after three months storage of tablets. The best-fit release kinetics was achieved with the Higuchi model, followed by the first-order plot.

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Stability of Solids and Solid Dosage Forms

Cited by 159 publications

References 91 publications

Influência da temperatura de secagem e da concentração de Aerosil®200 nas características dos extratos secos por aspersão da Schinus terebinthifolius Raddi (Anacardiaceae)

Influência da temperatura de secagem e da concentração de Aerosil®200 nas características dos extratos secos por aspersão da Schinus terebinthifolius Raddi (Anacardiaceae)

Effect of Counterion on the Solid State Photodegradation Behavior of Prazosin Salts

In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices

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