Stability of ranitidine in injectable solutions

Vehabović, Midhat; Hadzović, S; Stambolic, Fatima; Hadzic, Amina; Vranjes, Elvedina; Haracic, Ediba

doi:10.1016/s0378-5173(03)00067-x

Cited by 23 publications

(14 citation statements)

References 5 publications

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“…These histamine antagonists remain stable in the drinking water during this time 83,84 . The water bottles at this time were weighed before and after the water was changed, to be able to calculate the amount of water drank by each mouse and calculate the amount of drug taken in per mouse.…”

Section: Methodsmentioning

confidence: 99%

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice

et al. 2016

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Histamine receptor 2 (H2) antagonists are widely used clinically for the control of gastrointestinal symptoms, but also impact immune function. They have been reported to reduce tumor growth in established colon and lung cancer models. Histamine has also been reported to modify populations of myeloid-derived suppressor cells (MDSCs). We have examined the impact of the widely used H2 antagonist ranitidine, on both myeloid cell populations and tumor development and spread, in three distinct models of breast cancer that highlight different stages of cancer progression. Oral ranitidine treatment significantly decreased the monocytic MDSC population in the spleen and bone marrow both alone and in the context of an orthotopic breast tumor model. H2 antagonists ranitidine and famotidine, but not H1 or H4 antagonists, significantly inhibited lung metastasis in the 4T1 model. In the E0771 model, ranitidine decreased primary tumor growth while omeprazole treatment had no impact on tumor development. Gemcitabine treatment prevented the tumor growth inhibition associated with ranitidine treatment. In keeping with ranitidine-induced changes in myeloid cell populations in non-tumor-bearing mice, ranitidine also delayed the onset of spontaneous tumor development, and decreased the number of tumors that developed in LKB1−/−/NIC mice. These results indicate that ranitidine alters monocyte populations associated with MDSC activity, and subsequently impacts breast tumor development and outcome. Ranitidine has potential as an adjuvant therapy or preventative agent in breast cancer and provides a novel and safe approach to the long-term reduction of tumor-associated immune suppression.

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Section: Methodsmentioning

confidence: 99%

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice

et al. 2016

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“…The photochemical oxidation of lincomycin probably leads to Similarly, N-oxide and S-oxides might be the products resulting from the oxidation of ranitidine [26,27].…”

Section: Mechanistic Aspectsmentioning

confidence: 99%

Removal of drugs in aqueous systems by photoassisted degradation

et al. 2005

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Aqueous solutions of tetracycline, lincomycin and ranitidine were irradiated with UV light in homogeneous and heterogeneous systems. Two commercial polycrystalline TiO 2 powders (Degussa P25 and Merck) were used as photocatalysts. After 5 h, an appreciable photolytic degradation of tetracycline and ranitidine was observed while the degradation of lincomycin was noticeably lower. As far as the mineralization is concerned, a small decrease of the TOC values was measured in the case of tetracycline whereas negligible variations were found for lincomycin or ranitidine. The presence of the photocatalysts greatly enhanced the degradation rates of the drugs with respect to those observed during the homogeneous experiments. The Langmuir-Hinshelwood kinetic model adequately describes the experimental results and both the pseudo-first order kinetic constants of the reactions and the adsorption constants were calculated. Merck TiO 2 was more active than P25 Degussa for the photodegradation of tetracycline and ranitidine, whereas both photocatalysts showed similar performances for lincomycin. In the presence of TiO 2 Degussa P25, tetracycline was almost completely mineralized, but the reduction of the initial TOC was ca. 60% in the case of lincomycin and ranitidine. A less significant mineralization was observed by using Merck TiO 2 .

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“…There is a lack of information on the stability of repackaged syrups, and different dosage forms of ranitidine have been found to be susceptible to degradation under various environmental stresses, such as light, humidity, and temperature. [4][5][6] Volonte et al 4 reported that the stability of ranitidine tablets was deAm J Health-Syst Pharm-Vol 65 Feb 15, 2008 pendent on the formulation and the primary container. Ranitidine hydrochloride has also been found to be unstable in low pH buffer solutions.…”

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confidence: 99%

“…5 Moreover, water tends to adsorb onto ranitidine hydrochloride when stored over long periods of time, which may result in stickiness of the drug product and thereby affect its bioavailability and dissolution profiles. Vehabovic et al 6 found injectable solutions of ranitidine hydrochloride to be unstable when stored at 40 and 55 o C for six months.…”

mentioning

confidence: 99%