Stability of proteins in aqueous solution and solid state

Abstract

In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.

Preparation and Integrity Examination of Freeze Dried Kit of Trastuzumab-Immunoconjugates and Cold Labeled Immunoconjugates by Applying SDS-Page Electrophoresis

“…In order to prolong the life of protein pharmaceuticals, it is necessary to remove the water from the product. The commonly used method is lyophilization which obtains stable freeze dried kits (16).…”