Stability of penicillin G in ionic liquid [Bmim]PF 6

Qi, Jingxian; Liu, Qingfen; Liu, Huizhou

doi:10.1016/j.cjche.2018.02.030

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…The p K a of the acid group in the Penicillin G molecule is around 2.7, so its average affinity for hydrophobic adsorbents increases when the pH decreases since there is a greater quantity of neutral species present in the solution. However, the stability of this penicillin is much higher at neutral pH than at low pH. − Therefore, the efficiency of the adsorption process is expected to be a trade-off between the yield and the integrity of the antibiotic.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic Adsorption Followed by Desorption with Ethanol–Water for Recovery of Penicillin G from Fermentation Broth

et al. 2020

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The hydrophobic adsorption is an alternative to traditional organic solvent extraction for the recovery and purification of Penicillin G (PenG). However, there is a lack of information concerning the effect of process variables and technical feasibility while balancing product degradation. After assessing the integrity of PenG under different conditions, Amberlite XAD-4 was selected from among three different adsorbents. During the batch process using only 0.05 g XAD-4 /mL medium , the adsorption yield increased from 36% at pH 6 to 44% at pH 4. More than 90% of the antibiotic was captured from the fermentation broth using 0.083 g XAD-4 /mL medium in a 45 min batch performed at pH 4 and 4 °C. Moreover, there was no PenG degradation. The desorption conditions were evaluated, and 95% of the antibiotic could be recovered in only one batch using water−ethanol, which is an unexplored PenG desorption process. The results showed selective adsorption, indicating that the process can also be useful for purification purposes. Hydrophobic adsorption with ethanol desorption is efficient, scalable, and green and could be used in place of traditional methods or in extractive fermentation.

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Section: Introductionmentioning

confidence: 99%

Hydrophobic Adsorption Followed by Desorption with Ethanol–Water for Recovery of Penicillin G from Fermentation Broth

et al. 2020

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“…The dry AFRs are rich in organic fractions with 50% proteins and carbohydrates. [2][3][4] Considering the residual antibiotics are liable to cause serious environmental pollution and even the threat to the health of human beings and animals by inducing drug-resistant bacteria, [5][6][7][8] AFRs have been added to the list of hazardous waste since 2008 in China. Therefore, AFRs require harmless treatment before being discharged.…”

Section: Introductionmentioning

confidence: 99%

Dehydration kinetics of antibiotic fermentation residues by dehydration agents at room temperature

Guo

Zhou

Liu

et al. 2021

Env Prog and Sustain Energy

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Harmless disposal of antibiotics fermentation residues (AFRs) is required due to the risk of inducing drug-resistant via the residual antibiotics. AFRs are rich in colloidal water to be hardly removed by mechanical methods, leading to the energy-intensive dewatering. Dehydration agents (DAs) can be used to treat the wet AFRs, in which colloidal water was transferred into the hydrate of DA and formed solid AFRs-DA mixture at room temperature. In this article, the dehydration kinetics of AFRs was investigated systematically. The results show that the dehydration followed the firstorder kinetic equation and the main influences were temperature, feed ratio, and the particle size of DA. In addition, the quantitative relationship of kinetic parameters with the feed ratio and temperature were established, providing the basic data for further reducing the energy consumption of AFRs disposal.

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Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

et al. 2019

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Mesoporous material supported functionalized ionic liquids have been designed and synthesized, characterized and evaluated as novel heterogeneous catalysts for the Hantzsch reaction. The as-fabricated catalysts show good performance in the Hantzsch synthesis of 1,4-dihydropyridines under ambient conditions, especially the titanium incorporated mesoporous material supported ionic liquid Ti-SBA-15@IL-BF 4 , based on a synergetic effect of titanium site of mesoporous material carrier and the acidic sites of ionic liquid. In addition, the heterogeneous catalyst offers simple operation for recovery and the recycling test showed that it could be reused for five times without significant loss of catalytic activity.

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Stability of penicillin G in ionic liquid [Bmim]PF 6

Cited by 4 publications

References 17 publications

Hydrophobic Adsorption Followed by Desorption with Ethanol–Water for Recovery of Penicillin G from Fermentation Broth

Hydrophobic Adsorption Followed by Desorption with Ethanol–Water for Recovery of Penicillin G from Fermentation Broth

Dehydration kinetics of antibiotic fermentation residues by dehydration agents at room temperature

Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

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