Stability of Methoxyflurane Loaded Penthrox Inhaler

“…The inhaler has a dilutor hole; at sea level, the inhaler delivers 0.1 to 0.2% methoxyflurane, but covering the hole will increase the concentration to 0.2 to 0.4%. 4 An activated charcoal filter, included with the inhaler, can be fitted to the dilutor hole to scavenge waste gas and reduce the cumulative occupational exposure of rescue personnel. 5 Supplementary oxygen can also be given via a distal port.…”

Section: Discussionmentioning

confidence: 99%

Methoxyflurane for Procedural Analgesia at 4470 m Altitude

Wilkes¹,

Heath²,

Mason

2018

Wilderness & Environmental Medicine

View full text Add to dashboard Cite

Methoxyflurane is a volatile, fluorinated anesthetic agent with analgesic properties. Although no longer used as an anesthetic due to concerns regarding renal toxicity in high doses, it has enjoyed a resurgence as an inhaled analgesic in prehospital care and in the emergency department. The agent is nonflammable and leads to rapid, titratable analgesia without intravenous access. The Penthrox inhaler device is light, robust, and straightforward to administer. Consequently, it has been proposed as an ideal analgesic for the remote high altitude setting. We report its use for procedural analgesia during suprapubic aspiration for acute urinary retention at a remote rescue post at night, in cold winter conditions, at 4470 m altitude in Machermo, Nepal. We found that methoxyflurane provided rapid, effective analgesia for our patient's visceral and procedural pain. The inhaler was easy to administer, and the patient remained responsive to voice, with satisfactory oxygen saturation and respiratory rate throughout. We also briefly review the administration, dosing, efficacy, and safety of methoxyflurane and its role in remote medical care.

show abstract

“…Picture 1shows the Penthrox Inhaler. Penthrox inhaler contains 3 ml Methoxyflurane substances, which is inserted into the cavity of the inhaler tube, and then rotated around before inhaled through the mouth by the patient (Crankshaw, 2015).…”

mentioning

confidence: 99%

Pain Management With Penthrox Inhaler in Prehospital Care:literature Review

Setiaman¹,

Peristiowati²,

Ellina³

2021

IJAR

View full text Add to dashboard Cite

Introduction:Traumas that give symptoms of severe pains could lead to stress induced pain if not given an immediate pain relief. Penthroxinhaler an immediate pain reliever, can be given in pre-hospital services by ambulance officers (paramedics or ambulance nurses). Penthroxinhaler is a low-dose Methoxyflurane single-use inhaler, and has been used for more than 40 years in the medical field in managing trauma pain. Aim:The purpose of this study was to explore the original research related to the prospects of trauma pain management with Penthrox Inhaler, the benefits of using Penthrox inhaler in pre-hospital trauma pain management, and to identify the side effects from using Penthrox Inhaler based on researches published in international journals. Method:The method used in this literature review is the PICO method a type of systematic literature review. Problem/patient: Severe pain. Intervention: Penthrox Inhaler, Comparison: none. Outcome: Pain relief, Keyword : Pain relief. Result:The administration of Low Dose Methoxyflurane in cases of trauma pain showed a very significant effect.GivingLow Dose Methoxyflurane was given faster to the patientcompared to other drugs. With the provision of LDM, the pain reduction was with a VAS value, which stated very satisfying by 42.8% and satisfying 67.3%. The side effects of using gas drugs are generally seen, whether it causes neprotoxicity and the level of tolerability by the patient himself.Before giving Methoxyflurane to patients, must ensure that the oxygen saturation level is above 90% and the maximum dosage given must be 6 ml in the span of 2 hours to reduce side effects.Ambulance officers can be safe with an exposure time of 8 hours while administering Penthrox to patients.

show abstract

Stability of Methoxyflurane Loaded Penthrox Inhaler

Abstract: ABSTRACT

Cited by 4 publications

References 10 publications

Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers

Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers

Methoxyflurane for Procedural Analgesia at 4470 m Altitude

Pain Management With Penthrox Inhaler in Prehospital Care:literature Review

Contact Info

Product

Resources

About