Stability of Isoniazid and its Related Compounds. III. : Unaerobic Acid-Catalyzed Degradation of Isoniazid

Ternary mutual diffusion of isoniazid in aqueous sodium chloride, sodium hydroxide, and hydrochloric acid at T=298.15K

“…Some studies have been carried out on the stability of this drug in various media [22,23], showing a slow decomposition to isonicotinic acid and isonicotinamide, in acid media (HCl 0.5 mol Á dm À3 ) above T = (343 to 353) K or in basic media at T = 310 K but with NaOH concentrations above 0.5 mol Á dm À3 . Therefore our diffusion measurements were performed at temperatures and concentrations of NaOH and HCl, below those values, to assure that the decomposition of isoniazid is negligible during our measurements.…”

LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method

“…The stability of the drug has been investigated in various media, viz., aqueous solutions and plasma [9], frozen serum and plasma [10,11], solutions containing alcohol [12], sucrose and sorbitol [13]. There even exist a series of publications on the stability of isoniazid and its sodium methanesulfonate derivative [14][15][16][17][18][19]. In these, acid-catalyzed, base-catalyzed and oxidative degradation of isoniazid were investigated, and the evaluation of the degraded samples was done by initially passing them through ion exchange columns and subsequently analysis by UV.…”

Development of a green method for separation and identification of the degradation impurity of isoniazid by SFC-MS/MS

“…HPLC and LC/MS are reported for the stability of the INH and acid degradation products. [26][27][28][29][30][31][32] Only single eco-friendly method is available for determination of INH in xed dose combination. 33 Besides this method, the method based on capillary zone electrophoresis (CZE) was reported 34 for detection of INH and acid degradation products, which can be considered to be an eco-friendly method.…”