LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method

Influence of TiO2 morphology on the photocatalytic efficiency of direct Z-scheme g-C3N4/TiO2 photocatalysts for isoniazid degradation

“…Bhutani et al studied the LC and LC-MS stress decomposition behavior of ISN by applying different stress conditions [34]. Ustinova et al studied the photo-and oxidation degradation of isoniazid and metronidazole using Fenton's reagent [35].…”

Ternary mutual diffusion of isoniazid in aqueous sodium chloride, sodium hydroxide, and hydrochloric acid at T=298.15K

“…Isoniazid (isonicotinic hydrazide INH, figure 1) [1,2], first synthesized by Meyer and Mally in 1912 has been used since the 1950s as a first-line antituberculosis drug, characterized by an outstanding minimal inhibitory concentration in the human body [(0.1 to 0.17) mol Á dm À3 ] and having a high specificity toward Mycobacterium tuberculosis. This drug is often administered together with others, as currently recommended by international guidelines when the tuberculosis is still resistant, regardless of the existence of multiple classes of antibiotics.…”

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

“…4 The action mechanism of INH is not totally understood however, the pharmacological activity of the biologically active molecule is related to its chemical structure. 5,6 Several authors have reported on the stability of isoniazid [7][8][9][10] and its compatibility with drugs [11][12][13] and pharmaceutical excipients. 14 Given the above, the development of dosage forms containing isoniazid should be judicious.…”