Abstract:The compatibility between isoniazid (INH) and pharmaceutical excipients was studied using thermal analysis (DSC and TG/DTG) and vibrational spectroscopy (FTIR). Modifications in the peak shape, peak onset or peak maximum were verified using thermal analysis, especially DSC, in the physical mixtures. FTIR spectra showed good correlation between INH and most of excipients. Lactose and sodium metabisulfite were found to exhibit interactions with isoniazid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.