Stability of Indomethacin in Aqueous Solution. (1): Kinetic Studies and Effect of Solvents on the Hydrolysis of Indomethacin.

薫, 千葉; 賢尚, 高橋; 伸正, 早勢; 茂隆, 阿久津; 俊一, 稲垣

doi:10.5649/jjphcs1975.18.43

Cited by 7 publications

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“…It is known that an indomethacin molecule is subjected to hydrolysis in aqueous solutions. 28,29 At neutral pH this process is slow and considerably accelerated in alkaline solutions. It can be assumed that the decomposition of indomethacin can also be accelerated due to hydrolases that are present in bio objects.…”

Section: Systemmentioning

confidence: 99%

Niosomes modified with cationic surfactants to increase the bioavailability and stability of indomethacin

2021

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Niosomes based on the nonionic surfactant Tween 80 and cholesterol and modifi ed with cationic surfactants (cetyltrimethylammonium bromide or its carbamate-bearing analog) were formed by the thin fi lm hydration method. Such a modifi cation of niosomes provides an increase in their ζ potential up to 60 mV, whereas the hydrodynamic diameter of the particles is 100 nm and remains nearly unchanged when the content of the cationic surfactant is varied from 1 to 3 wt.%. The inclusion of anti-infl ammatory drug indomethacin in niosomes makes it possible to exceed its limiting solubility in water by nearly 20 times. The dialysis method demonstrated an increase in the release time of the encapsulated drug by 1.5 times, which is a prerequisite for its prolonged action in biosystems. The study of the kinetics of indomethacin cleavage in alkaline media revealed that the niosomes enhanced the stability of the drug providing protection against hydrolytic destruction processes.

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Section: Systemmentioning

confidence: 99%

Niosomes modified with cationic surfactants to increase the bioavailability and stability of indomethacin

2021

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“…Topical administration to the oral mucous membrane is an alternative route that specifically aims the affected area and avoid systemic side effects [ 11 , 12 ]. For oral mucositis pain control, oral sprays with indomethacin (IM), an NSAID, were developed as an in-hospital preparation to reduce oral mucositis pain and reduce opioid use [ 13 , 14 , 15 ]. However, there are limitations in sustained drug delivery by spraying onto the oral mucosa and the stability of the preparation is not sufficient.…”

Section: Introductionmentioning

confidence: 99%

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

et al. 2020

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In order to relieve pain due to oral mucositis, we attempted to develop mucoadhesive microparticles containing indomethacin (IM) and gel preparations with IM microparticles that can be applied to the oral cavity. The mucoadhesive microparticles were prepared with a simple composition consisting of IM and polyvinyl alcohol (PVA). Two kinds of PVA with different block properties were used, and microparticles were prepared by heating-filtration and mixing-drying. From the X-ray powder diffraction patterns, differential scanning calorimetry thermograms, and morphological features of the IM microparticles, IM should exist as polymorphic forms in the microparticles. Rapid drug release properties were observed in the IM microparticles. Increased drug retention was observed in IM microparticles containing PVA, and the IM-NK(50) gel, using a common block character PVA and heating-filtration, showed good long-term drug retention properties. In vivo experiments showing significantly higher drug concentrations in the oral mucosa were observed with IM microparticles prepared by heating-filtration, and the IM-NK(50) gel maintained significantly higher drug concentrations in the oral mucosa. From these results, the IM-NK(50) gel may be useful as a preparation for relieving oral mucositis pain.

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The physicochemical characteristics and bioavailability of indomethacin from β-cyclodextrin, hydroxyethyl-β-cyclodextrin, and hydroxypropyl-β-cyclodextrin complexes

Jambhekar

Casella

Maher

2004

International Journal of Pharmaceutics

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Stability of Indomethacin in Aqueous Solution. (1): Kinetic Studies and Effect of Solvents on the Hydrolysis of Indomethacin.

Cited by 7 publications

References 0 publications

Niosomes modified with cationic surfactants to increase the bioavailability and stability of indomethacin

Niosomes modified with cationic surfactants to increase the bioavailability and stability of indomethacin

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

The physicochemical characteristics and bioavailability of indomethacin from β-cyclodextrin, hydroxyethyl-β-cyclodextrin, and hydroxypropyl-β-cyclodextrin complexes

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