Niosomes modified with cationic surfactants to increase the bioavailability and stability of indomethacin

Abstract

Niosomes based on the nonionic surfactant Tween 80 and cholesterol and modifi ed with cationic surfactants (cetyltrimethylammonium bromide or its carbamate-bearing analog) were formed by the thin fi lm hydration method. Such a modifi cation of niosomes provides an increase in their ζ potential up to 60 mV, whereas the hydrodynamic diameter of the particles is 100 nm and remains nearly unchanged when the content of the cationic surfactant is varied from 1 to 3 wt.%. The inclusion of anti-infl ammatory drug indomethacin in niosomes makes it possible to exceed its limiting solubility in water by nearly 20 times. The dialysis method demonstrated an increase in the release time of the encapsulated drug by 1.5 times, which is a prerequisite for its prolonged action in biosystems. The study of the kinetics of indomethacin cleavage in alkaline media revealed that the niosomes enhanced the stability of the drug providing protection against hydrolytic destruction processes.

Preparation, Optimization and In vitro Evaluation of Doxorubicin‐loaded into Hyaluronic Acid Coated Niosomes Against Breast Cancer

“…A thin film was formed by gentle evaporation of the organic solvent using rotary evaporator (BUCHI, R‐300) at 45 °C, and 40 rpm, with an initial pressure 500 mbar that gradually decreased to 100 mbar. Cationic niosomes were formed by hydration the thin film with DOX aqueous solution of 1 mg/3.0 mL deionized water for 45 min vigorous stirring [30] . Niosomes downsizing was performed utilizing probe sonication the samples for 5 min at 45 %, followed by 3 min at 35 % of 100 watt.…”

“…Cationic niosomes were formed by hydration the thin film with DOX aqueous solution of 1 mg/3.0 mL deionized water for 45 min vigorous stirring. [30] Niosomes downsizing was performed utilizing probe sonication the samples for 5 min at 45 %, followed by 3 min at 35 % of 100 watt. HA acid coating was performed by incubation equal volumes of cationic niosomes and HA (0.3 mg/ml aqueous solution) at room temperature for 1.0 hr with gentle mixing at 300 rpm.…”

Hyaluronic Acid – Coated Niosomes for Curcumin Targeted Delivery into Breast Cancer Cells

“…The lipid thin film was formed by gently evaporating the organic solvent using a rotary evaporator (BUCHI, R-300) at 45 °C and 40 rpm with an initial pressure of 500 mbar and gradually decreasing to 100 mbar. Cationic niosomes were formed by hydrating the thin film with 3.0 mL of deionized water for 45 min with vigorous stirring.. [18] Niosome size reduction was done by probe sonicating the sample at 45 % for 5 min followed by 3 min at 35 % of 100 watts. HA acid coating was performed by incubating equal amounts of cationic niosomes and HA (1 mg/mL aqueous solution) for 1.0 h at room temperature with gentle mixing at 300 rpm.…”

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

“…Among the methods for imparting a positive charge, the incorporation of cationic surfactants into niosomes is the most often used pathway [160][161][162]. This may increase the stability of composition and may affect the loading efficiency and the release rate of bioactive compounds [163]. Thus, niosomes are a fairly new and efficient drug delivery system.…”