Stability of in <sup>111</sup>In-ligand Complexes Studied by TDPAC

Shpinkova, L.G.; Kulakov, V. N.; Сорокин, А.А.; Ryasny, G.K.; Komissarova, B.A.; Nikitin, S. M.

doi:10.1515/zna-1998-6-759

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…111 In ( T 1/2 = 2.8 d), as one of the common isotopes used in nuclear medicine, is particularly suitable for single photon emission computed tomography (SPECT) , and for targeted Auger therapy . At the same time, indium-111 is one of the most suitable radionuclides for PAC spectroscopy . Moreover, there are several other elements for which there exist multiple isotopes, where some can be used in targeted imaging and therapy, and others are suitable for PAC.…”

Section: Introductionmentioning

confidence: 99%

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

et al. 2020

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One of the key components of radiopharmaceuticals for targeting imaging and therapy is a stable bifunctional chelating system to attach radionuclides to selective delivery systems. After-effects of radioactive decay can cause the release of a radioactive isotope from its chelation agent. Perturbed angular correlation (PAC) of γ-rays has become a unique technique to study the behavior of complexes formed between a chelating agent and radionuclide in vivo (in real time) over a relevant range of concentrations (10 −12 M). In the present work, four radionuclides, 111 In, 111m Cd, and 152, 154 Eu, were investigated with diethylenetriaminepentaacetic acid (DTPA) at different pH values to determine the stability constants of the complexes as well as the effects of post-decay processes, which play a major role in determining the suitability of these complexes for application as radiopharmaceuticals (e.g., in vivo generators). The study provides a convenient parameter for the characterization of radionuclide−chelator systems using the PAC method. PAC is proven to be a suitable tool to study novel chelators and radiopharmaceutical precursors attached to radiometals.

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Section: Introductionmentioning

confidence: 99%

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

et al. 2020

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“…La posibilidad de preparar y estudiar complejos de metales con moléculas orgánicas de bajo peso molecular usando esta técnica ha atraído la atención de la comunidad TDPAC interdisciplinaria desde hace varios años (1)(2)(3)(4)(5) . Sin embargo, la formación simultánea de productos inorgánicos en la muestra no ha sido tenida en cuenta, conduciendo en muchos casos a interpretaciones erróneas de los resultados obtenidos.…”

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Tdpac Experiments With Hafnium Fluoride in Organic Compounds

Chain

Pasquevich

2012

AnAFA

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Agentes quelantes poliaminocarboxilados, como el ácido etilendiaminotetraacético (EDTA) y el ácido dietilentriaminopentaacético (DTPA), forman complejos estables con muchos cationes de metales pesados y son de amplio uso en el campo industrial y biomédico. En este trabajo la espectroscopía TDPAC ha sido utilizada para investigar la formación de compuestos de hafnio a partir de 181 Hf-HfF 4 y ácidos poliaminocarboxílicos. En todos los casos la mezcla de los reactivos conduce a la precipitación de sólidos que fueron medidos húmedos a temperatura ambiente. Se observaron distintos comportamientos dependiendo del cociente átomos de fluor/átomos de sodio presente en la muestra. Se verificó la aparición de Na 3 HfF 7 para cocientes F/Na de aproximadamente 1,5 y de Na 5 Hf 2 F 13 para cocientes entre 3 y 4. No se observó evidencia de la complejación de hafnio por los ácidos poliaminocarboxílicos.Palabras Claves: reacciones químicas, complejos de hafnio, tridecafluorodihafnato de sodio, heptafluorohafnato de sodio Polyamino carboxilate chelating agents, like ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA), form stable complexes with many heavy metals ions and are of spread use in the industrial and biomedical field. In this paper TDPAC spectroscopy has been used to investigate the formation of hafnium compounds prepared from 181 Hf-HfF 4 and polyaminocarboxylic acids. In all cases the mixing of the reagents leads to the precipitation of solids that were measured at room temperature. Different behaviors were observed depending on the ratio fluorine/sodium atoms present in the sample. The apparition of Na 3 HfF 7 was verified when the ratio F/Na was approximately 1.5 and Na 5 Hf 2 F 13 appeared when this ratio was between 3 and 4. No evidence of hafnium complexation by the polyaminocarboxilic acids was observed.

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“…The possibility of preparing and studying low molecular weight complexes using this technique has attracted the attention of the interdisciplinary TDPAC community for many years [1][2][3][4][5]. However, the simultaneous formation of inorganic products has not been taken into account, leading in many cases to misinterpretation of the obtained results.…”

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On hafnium chelation by EDTA and DTPA for TDPAC experiments

Chain

Pasquevich

2010

Hyperfine Interact

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Polyaminocarboxilate chelating agents, like ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA), form stable complexes with many heavy metals ions and are of spread use in the industrial and biomedical field. In this paper, Time Differential Perturbed Angular Correlations (TDPAC) spectroscopy has been used to investigate the formation of Hf-complexes prepared from 181 Hf-HfF 4 and polyaminocarboxylic acids, by taking into account the possible formation of inorganic compounds. The obtained wet precipitates were measured at room temperature. Different behaviors were observed depending on the ratio fluorine/sodium atoms present in the sample. The obtaining of sodium heptafluorohafnate Na 3 HfF 7 was verified when the ratio F/Na was approximately 1.5 and tridecafluorodihafnate Na 5 Hf 2 F 13 appeared for relations between 3 and 4. No evidence of hafnium complexation by the polyaminocarboxilic acids was observed.

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Stability of in ¹¹¹In-ligand Complexes Studied by TDPAC

Cited by 13 publications

References 5 publications

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

Tdpac Experiments With Hafnium Fluoride in Organic Compounds

On hafnium chelation by EDTA and DTPA for TDPAC experiments

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Stability of in 111In-ligand Complexes Studied by TDPAC

Cited by 13 publications

References 5 publications

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticals

Tdpac Experiments With Hafnium Fluoride in Organic Compounds

On hafnium chelation by EDTA and DTPA for TDPAC experiments

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Product

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Stability of in ¹¹¹In-ligand Complexes Studied by TDPAC