Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications

Szymańska, Emilia; Winnicka, Katarzyna

doi:10.3390/md13041819

Cited by 665 publications

(384 citation statements)

References 106 publications

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“…In preparation step, the active paper was added to chitosan and oleoresin emulsion that caused water content more than the reference. Chitosan was hygroscopic and have a greater capability to form hydrogen bonding [15,16]. The presence of Tween 80 emulsifier in the chitosan film increased hygroscopicity due to its hydrophilic groups [16].…”

Section: Resultsmentioning

confidence: 99%

Characterization of active paper packaging incorporated with ginger pulp oleoresin

Wiastuti

Khasanah

Kawiji

et al. 2016

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Utilization of ginger pulp waste from herbal medicine and instant drinks industry in Indonesia currently used for fertilizer and fuel, whereas the ginger pulp still contains high oleoresin. Active paper packaging were developed incorporated with ginger pulp oleoresin (0%, 2%, 4%, and 6% w/w). Physical (thickness, tensile strength, and folding endurance, moisture content), sensory characteristics and antimicrobial activity of the active paper were evaluated. Selected active paper then were chemically characterized (functional groups). The additional of ginger pulp oleoresin levels are reduced tensile strength, folding endurance and sensory characteristic (color, texture and overall) and increased antimicrobial activity. Due to physical, sensory characteristic and antimicrobial activity, active paper with 2% ginger pulp oleoresin incorporation was selected. Characteristics of selected paper were 9.93% of water content; 0.81 mm of thickness; 0.54 N / mm of tensile strength; 0.30 of folding endurance; 8.43 mm inhibits the growth of Pseudomonas fluorescence and 27.86 mm inhibits the growth of Aspergillus niger (antimicrobial activity) and neutral preference response for sensory properties. For chemical characteristic, selected paper had OH functional group of ginger in 3422.83 cm -1 of wave number and indicated contain red ginger active compounds.

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Section: Resultsmentioning

confidence: 99%

Characterization of active paper packaging incorporated with ginger pulp oleoresin

Wiastuti

Khasanah

Kawiji

et al. 2016

IOP Conf. Ser.: Mater. Sci. Eng.

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“…In Figure 3a, 3b and 3c, the clear inhibitory zones around the drug-eluting stents against the biofilm producing test cultures were presented. The rate of degradation of the polymer in the PBS was considered to be directly proportional to the rate of release of drugs 28 . When the rate of degradation was high, then the release concentration was also found out to be high.…”

Section: Discussionmentioning

confidence: 99%

Drug Eluting Stents Coated With Rapamycin Crystals for the Prevention of Restenosis and Biofilm Formation

Prasanth¹,

Saravanakumari²

2017

Int. J. Res. Ayurveda Pharm.

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Restenosis and biofilm formation during coronary stent implantation were considered to increase the complications of cardiovascular disease. To prevent these dual problems, drug-eluting stents coated with crystallized drug-polymer mixtures (Rapamycin-Polyvinyl pyrrolidone) were developed and its efficacy was investigated in the present study. Single layer coating using seeding and crystallization of drug-polymer mixture on the stent surface were carried out for effective drug delivery at the target site. Efficacy of rapamycin release concentration from the coated drug-eluting stents for the prevention of restenosis using High performance liquid chromatography was determined. Antibacterial activity of the drug-eluting stents against biofilm organisms was simultaneously studied. High performance liquid chromatography established the efficiency of modified coating technique and controlled release of rapamycin from drug-polymer mixture. Antibacterial activity of drug-eluting stents showed maximum inhibitory zone of 31.3mm against Staphylococcus aureus for 2X crystallized rapamycin coated stents. SEM images of rapamycin coatings on the stents exhibits extremely large uniform and continuous layer of parallelogram shaped rapamycin crystals in drug loaded stents. The sustained release of drugs fulfilled the primary aim of developing an anti-infective method for post-operative infection caused by biofilm organisms and also the prevention of restenosis.

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“…Menurut Szymańska & Winnicka (2015) uji swelling dapat membantu dalam menentukan kemampuan kitosan untuk mengikat molekul air dan bagaimana perubahannya ketika disimpan dalam jangka waktu tertentu. Uji ini dilakukan dengan menimbang sejumlah tertentu sampel, kemudian sampel tersebut dimasukkan ke dalam buffer fosfat dengan volume tertentu dan didiamkan selama 24 jam.…”

Section: Sifat Swellingunclassified

Adsorpsi Kolesterol Lemak Sapi dengan N-Metil Kitosan

Kurniasih

Setyaningtyas²,

Kartika³

et al. 2018

J. Rekayasa Kim. Lingkung.

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AbstrakN-metil kitosan merupakan derivat kitosan yang memiliki muatan polikationik dan dapat bereaksi dengan muatan negatif seperti kolesterol. Penelitian ini bertujuan untuk mensintesis N-metil kitosan dan mempelajari adsorpsi kolesterol oleh N-metil kitosan. N-metil kitosan disintesis dari kitosan melalui mekanisme reduktif aminasi. N-metil kitosan hasil sintesis dikarakterisasi dengan FTIR dan diukur kadar air, berat molekul dan indeks swellingnya. Nmetil kitosan kemudian diuji kemampuan adsorpsinya terhadap kolesterol lemak sapi. Studi adsorpsi berupa isoterm adsorpsi juga telah dilakukan. Hasil penelitian menunjukan N-metil kitosan hasil sintesis memiliki kadar air sebesar 5,17%, bobot molekul 130.106,80 g/mol, dan indeks swelling 495,04%. Adsorpsi kolesterol menggunakan N-metil kitosan mengikuti model adsorpsi isoterm Freundlich. N-metil kitosan memiliki kemampuan adsorpsi terhadap kolesterol dalam lemak sapi sebesar 11,61 mg/g. Kata kunci: adsorpsi, lemak sapi, kitosan, kolesterol, N-metil kitosan Abstract N-methyl chitosan is a chitosan derivative that has a polycationic charge and can react to a negative charge such as cholesterol. This study aims to synthesize N-methyl chitosan and study the adsorption of cholesterol by N-methyl chitosan. In this research, N-methyl chitosan has been synthesized from chitosan through reductive amination mechanism. The synthesized Nmethyl chitosan was characterized by FTIR and measured moisture content, molecular weight, and swelling index. N-methyl chitosan then tested its adsorption ability against cow's fat cholesterol. The adsorption study of adsorption isotherm has also been performed. The result shows N-methyl chitosan synthesized has characters such as water content 5.17%, molecule weight 130,106.80 g/mol, and swelling index 495.04%. The adsorption of cholesterol by Nmethyl chitosan follow Freundlich isotherm adsorption model. Adsorption ability of N-methyl chitosan towards cholesterol fat cow is 11.61 mg/g.

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Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications

Cited by 665 publications

References 106 publications

Characterization of active paper packaging incorporated with ginger pulp oleoresin

Characterization of active paper packaging incorporated with ginger pulp oleoresin

Drug Eluting Stents Coated With Rapamycin Crystals for the Prevention of Restenosis and Biofilm Formation

Adsorpsi Kolesterol Lemak Sapi dengan N-Metil Kitosan

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