Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions

Dołhań, Agnieszka; Jelińska, Anna; Bębenek, Marcelina

doi:10.1155/2014/583461

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…Cefquinome is a fourth‐generation aminothiazolyl cephalosporin that was developed solely for veterinary use. The zwitterion molecular structure of cefquinome facilitates penetration of the outer plasma membrane of Gram‐negative bacteria in a pH‐dependent manner, and the introduction of a methoxyimino‐aminothiazolyl moiety into the acyl side chain conferred resistance to inactivation by β‐lactamases (Dołhań, Jelińska, & Bębenek, ). Cefquinome is considered a time‐dependent antimicrobial agent with a low in vitro postantibiotic effect against S .…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of intramammary cefquinome in lactating goats with and without experimentally inducedStaphylococcus aureusmastitis

Badawy

Amer

Kamel

et al. 2019

Vet Pharm & Therapeutics

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Values for pharmacokinetic variables are usually obtained in healthy animals, whereas drugs are frequently administered to diseased animals. This study investigated cefquinome pharmacokinetics in healthy goats and goats with experimentally induced mastitis. Five adult lactating goats received 75 mg of cefquinome intramammary infusion using a commercially available product into one udder half in healthy goats and goats with clinical mastitis that was induced by intracisternal infusion of 100 cfu of Staphylococcus aureus ATCC 29213 suspended in 5 ml of sterile culture broth. Cefquinome concentrations were determined in plasma and skimmed milk samples using high‐performance liquid chromatography (HPLC). Pharmacodynamics was investigated using the California Mastitis Test and pH of milk. Experimentally induced mastitis significantly increased the California Mastitis Test score and pH, and decreased the maximal cefquinome concentration and shortened the half‐life in milk when compared to healthy goats. In conclusion, mastitis facilitated the absorption of cefquinome from the mammary gland of lactating goats and induced marked changes in milk pH, emphasizing the importance of performing pharmacokinetic studies of antimicrobial agents in infected animals.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of intramammary cefquinome in lactating goats with and without experimentally inducedStaphylococcus aureusmastitis

Badawy

Amer

Kamel

et al. 2019

Vet Pharm & Therapeutics

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“…Chromatographic separation and quantitative analysis were performed by using an HPLC method [12]. The analytical system consisted of a Shimadzu SPD-20A Prominence UV/VIS detector, a Rheodyne with a 50 lL loop.…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…The flow rate was 1.0 mL/min and UV detection was performed at 268 nm. Although the method was evaluated and validated for the stress degradation study, the selectivity was examined during a stability study of CFQ [12].…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…HPLC [12] and colorimetric methods [13] for the determination of cefquinome sulfate in bulk and dosage form were developed. Shantier's studies showed that cefquinome sulfate solutions are degraded via hydrolysis, which appears to depend on temperature and hydroxide ion concentration [13].…”

Section: Introductionmentioning

confidence: 99%

“…The HPLC and TLC methods developed in this study were successfully used to separate the alkaline degradation products from the parent compound [17]. Also the stability of cefquinome sulfate in intravenous solutions was studied [12].…”

Section: Introductionmentioning

confidence: 99%

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Critical parameters for the stability of cefquinome sulfate in aqueous solutions and solid phase

Dołhań

Urbaniak

Manuszewska

et al. 2017

Reac Kinet Mech Cat

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Cefquinome sulfate is a veterinary, parenteral, fourth-generation cephalosporin with a methoxyimino-aminothiazolyl moiety into the acyl side chain and the quaternary quinoline group at position 3 of the cefem ring. Cefquinome sulfate is known to undergo degradation, which could be additionally increased by the presence of some critical factors such as temperature, relative air humidity, buffer components as well as hydrogen and hydroxide ions. The aim of this study was to evaluate the factors underlying the stability of cefquinome sulfate (CFQ) in aqueous solution and in the solid state taking into account general and specific acid-base hydrolysis in the pH range 0.45-10.48 at 343 K; the effect of temperature on the stability at 0% RH and an increased relative air humidity (RH = 76.4%); the influence of relative air humidity at 343 K (66.5-90%). To determine the observed rate constants, an isocratic HPLC-UV method was used. The three pK a values of cefquinome sulfate, kinetic (k obs. , k pH ), and activation parameters (E a , DH = , and DS = ) were determined.

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Faecal concentrations of ceftiofur metabolites in finisher pigs administered intramuscularly with ceftiofur

Gaire

Salas

Dunmire

et al. 2021

Veterinary Medicine & Sci

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The objective of this study was to determine the effects of dietary fibre level and source on faecal ceftiofur metabolites concentrations after intramuscular administration of therapeutic ceftiofur hydrochloride in finisher pigs. Pens of finisher pigs (n = 36), with an equal number of barrows and gilts, were randomly assigned to 1 of 3 dietary treatment groups: basal diet composed of corn grain and soy bean meal with no supplement and formulated to contain 8.7% neutral detergent fibre (NDF), supplemented with 20% distillers dried grains with solubles (a byproduct of the ethanol production from corn grain) formulated to contain 13.6% NDF, primarily insoluble fibre or supplemented with 14.5% sugar beet pulp formulated to contain 13.6% NDF. Faecal samples were collected 6–8 hr after ceftiofur injection from treated and untreated pen‐mate pigs on days 1 and 3 of the 3‐day treatment regimen. Faecal concentrations of ceftiofur metabolites, including the major metabolite, desfuroylceftiofur, were analysed by reverse‐phase high pressure liquid chromatography with ultraviolet detection. Overall, the faecal concentrations of ceftiofur metabolites did not differ significantly between the dietary treatments. The mean concentrations of metabolites tended to be lower (p = .1) on day 3 compared to day 1 of the 3‐day treatment regimen. Faecal concentrations of metabolites were not affected by the gender of the finisher pigs. The concentrations of ceftiofur metabolites in the faeces are likely reflective of the microbial activity in the hindgut. Our data suggest that the fibre level and source used in the study did not affect the faecal concentrations of ceftiofur metabolites.

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Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions

Cited by 7 publications

References 27 publications

Pharmacokinetics and pharmacodynamics of intramammary cefquinome in lactating goats with and without experimentally inducedStaphylococcus aureusmastitis

Pharmacokinetics and pharmacodynamics of intramammary cefquinome in lactating goats with and without experimentally inducedStaphylococcus aureusmastitis

Critical parameters for the stability of cefquinome sulfate in aqueous solutions and solid phase

Faecal concentrations of ceftiofur metabolites in finisher pigs administered intramuscularly with ceftiofur

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