Critical parameters for the stability of cefquinome sulfate in aqueous solutions and solid phase

Dołhań, Agnieszka; Urbaniak, Bartosz; Manuszewska, Monika; Klause, Robert; Tomczak, Szymon; Muszalska, Izabela; Sobczak, Agnieszka; Jelińska, Anna

doi:10.1007/s11144-017-1257-0

Cited by 5 publications

(4 citation statements)

References 18 publications

(25 reference statements)

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“…However, some drugs are inherently hard-to-crystallize drugs and used only in the amorphous form. There are no reports about crystalline CFQ in the literature, and only several crystalline salt forms of CFQ were reported. , …”

Section: Resultsmentioning

confidence: 99%

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Reverse Antisolvent Method To Avoid Jelly-like Phase Generation and Preparation of Crystalline Cefquinome

Wang

Zhang

Gao

et al. 2019

Crystal Growth & Design

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In the pharmaceutical industry, crystalline products are preferred because of their higher purity, chemical and physical stability, as well as tunability through crystal engineering. In this study, a crystalline cefquinome (CFQ) product was prepared for the first time. A reverse antisolvent crystallization (RAC) recipe was proposed to avoid the formation of a jelly-like phase (JLP) during the solution crystallization process. A comprehensive characterization and analysis were conducted for the undesirable JLP by using thermogravimetric analysis and rotational rheometry. The results show that the JLP is a semisolid fluid, and it hinders nucleation and growth of crystals. The formation of JLP should be considered as an important factor of lacking crystalline CFQ products in past decades. In this work, the ternary phase diagram was determined to study the mechanism of the RAC process and analyze it for further optimization. The optimized crystallization process was monitored and analyzed by powder X-ray diffraction, in situ Raman spectroscopy, and in situ focused beam reflectance measurement, and produced a higher crystallinity product. In addition, the solubility of the crystalline product and the commercial product was measured in three solvents. The results indicate a higher solubility of the crystalline CFQ product compared to the commercial product which shows great potential for further application.

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Section: Resultsmentioning

confidence: 99%

“…There are no reports about crystalline CFQ in the literature, and only several crystalline salt forms of CFQ were reported. 20,21 To produce a higher quality crystal product of CFQ, selecting the appropriate solvent as antisolvent is of importance. The solvents must meet two basic principles:…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Reverse Antisolvent Method To Avoid Jelly-like Phase Generation and Preparation of Crystalline Cefquinome

Wang

Zhang

Gao

et al. 2019

Crystal Growth & Design

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“…Stability study and kinetic monitoring of cefquinome sulfate using cyclodextrin-based ion-selective electrode were developed by Yehia AM, et al, 38 . Shantier SW et al and Dołhań A et al, 39,40 developed chromatographic and spectrophotometric methods for the analysis and stability studies of cefquinome sulphate in bulk and pharmaceutical dosage forms.…”

Section: Methods Of Analysismentioning

confidence: 99%

Characteristics, Properties and Analytical Methods of Cefquinome - A Review

2019

Chem Sci Trans

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Drugs have been used for the treatment of infectious diseases since the 17 th century. However, chemotherapy as a science began in the first decade of the 20 th century with understanding of the principles of selective toxicity, the specific chemical relationships between microbial pathogens and drugs, the development of drug resistance and the role of combined therapy. Analysis of such drugs, whether used for treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety. Thus, this review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for cefquinome, a fourth generation cephalosporine used to treat infections caused by gram-positive and gram-negative microorganisms.

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“…Generally, cephalosporin has been susceptible to degradation even in solution (12,13) or in solid states (14). CFQ, without exception, shows low stability toward acidic and alkaline hydrolysis, along with its susceptibility to photodegradation and thermal decomposition (15). In this work, stability study of CFQ was performed using two membrane-selective electrodes, one without ionophore (sensor 1) and the other with ionophore (sensor 2).…”

mentioning

confidence: 99%

Stability Study and Kinetic Monitoring of Cefquinome Sulfate Using Cyclodextrin-Based Ion-Selective Electrode: Application to Biological Samples

Yehia

Arafa

Abbas

et al. 2016

Journal of AOAC INTERNATIONAL

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Two novel cefquinome sulfate (CFQ)-selective electrodes were performed with dibutyl sebacate as a plasticizer using a polymeric matrix of polyvinyl chloride. Sensor 1 was prepared using sodium tetraphenylborate as a cation exchanger without incorporation of ionophore, whereas 2-hydroxy propyl β-cyclodextrin was used as ionophore in sensor 2. A stable, reliable, and linear response was obtained in concentration ranges 3.2 × 10(-5) to 1 × 10(-2) mol/L and 1 × 10(-5) to 1 × 10(-2) mol/L for sensors 1 and 2, respectively. Both sensors could be sufficiently applied for quantitative determination of CFQ in the presence of degradation products either in bulk powder or in pharmaceutical formulations. Sensor 2 provided better selectivity and sensitivity, wider linearity range, and higher performance. Therefore it was used successfully for accurate determination of CFQ in biological fluids such as spiked plasma and milk samples. Furthermore, an online kinetic study was applied to the CFQ alkaline degradation process to estimate the reaction rate and half-life with feasible real-time monitoring. The developed sensors were found to be fast, accurate, sensitive, and precise compared with the manufacturer's reversed-phase chromatographic method.

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Critical parameters for the stability of cefquinome sulfate in aqueous solutions and solid phase

Cited by 5 publications

References 18 publications

Reverse Antisolvent Method To Avoid Jelly-like Phase Generation and Preparation of Crystalline Cefquinome

Reverse Antisolvent Method To Avoid Jelly-like Phase Generation and Preparation of Crystalline Cefquinome

Characteristics, Properties and Analytical Methods of Cefquinome - A Review

Stability Study and Kinetic Monitoring of Cefquinome Sulfate Using Cyclodextrin-Based Ion-Selective Electrode: Application to Biological Samples

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