Stability of ascorbyl palmitate in topical microemulsions

Špiclin, Polona; Gašperlin, Mirjana; Kmetec, Vojko

doi:10.1016/s0378-5173(01)00715-3

Cited by 120 publications

(66 citation statements)

References 6 publications

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“…Tel: +81-29-838-8025; Fax: +81-29-838-8122; E-mail: isaok@affrc.go.jp is used in commercial antioxidant preparations due to its greater lipid solubility. 19) L-Ascorbic acid and its fatty acid esters are used as food additives, antioxidants, browning inhibitors, reducing agents, flavor stabilizers, dough modifiers, and color stabilizers. 20,21) Encapsulating L-ascorbic acid in emulsion systems is highly recommended due to its hydrophilic nature and rapid degradation in bulk aqueous systems.…”

Section: ) L-mentioning

confidence: 99%

Preparation and Characterization of Water-in-Oil-in-Water Emulsions Containing a High Concentration ofL-Ascorbic Acid

Khalid

Kobayashi

Neves

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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This study sought to encapsulate a high concentration of L-ascorbic acid, up to 30% (w/v), in the inner aqueous phase of water-in-oil-water (W/O/W) emulsions with soybean oil as the oil phase. Two-step homogenization was conducted to prepare W/O/W emulsions stabilized by a hydrophobic emulsifier and 30% (v/v) of W/O droplets stabilized by a hydrophilic emulsifier. First-step homogenization prepared W/O emulsions with an average aqueous droplet diameter of 2.0 to 3.0 m. Second-step homogenization prepared W/O/W emulsions with an average W/O droplet diameter of 14 to 18 m and coefficients of variation (CVs) of 18% to 25%. The results indicated that stable W/O/W emulsions containing a high concentration of L-ascorbic acid were obtained by adding gelatin and magnesium sulfate in the inner aqueous phase and glucose in both aqueous phases. L-Ascorbic acid retention in the W/O/W emulsions was 40% on day 30 and followed first-order kinetics.

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Section: ) L-mentioning

confidence: 99%

Preparation and Characterization of Water-in-Oil-in-Water Emulsions Containing a High Concentration ofL-Ascorbic Acid

Khalid

Kobayashi

Neves

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…Therefore, the application of vitamin C in various fields of cosmetics, dermatologicals, or pharmaceuticals are limited despite its benefits. [17,[22][23][24][25] Additionally, to exploit the TDDS more efficiently scientists have worked on some combinational approaches for manufacturing TDDS by iontophoresis, electroporation, ultrasound, and pressure waves, which subsequently reported the synergistic effect of TDDS. [26] In this study, vibrating microneedles de-…”

Section: Introductionmentioning

confidence: 99%

Enhancement of skin permeation of vitamin C using vibrating microneedles

Lee

Baek

Kwag

et al. 2017

Transl Clin Pharmacol

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This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC 0 -∞ and C max increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.

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“…1,2 However, practical application of AsA has greatly been limited due to its low chemical stability and hydrophilic nature. To overcome these limitations, ascorbyl palmitate (AsP) has been introduced, which has enhanced chemical stability and lipophilicity, certainly leading to increased skin absorption ability.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Evaluation of Freeze-dried Liposomes Loaded with Ascorbyl Palmitate Enabling Anti-aging Therapy of the Skin

2007

Bulletin of the Korean Chemical Society

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To prepare freeze-dried ascorbyl palmitate (AsP)-containing liposome which can protect the drug from moisture attack and be used instantly by mixing with water for anti-aging and skin whitening therapy, AsP was encapsulated into liposomes and freeze-dried with trehalose. The freeze-dried liposome formulations were characterized by measuring water contents, particle size, time required for complete reconstitution. With the freeze-dried liposomes, we performed the stability test under accelerated conditions, skin permeation and localization test. The measurement of the time to perfect reconstitution showed that the freeze-dried liposomes can be changed to their initial state rapidly and short term stability test of AsP in reconstituted liposomes under accelerated conditions confirmed that the stability of AsP was considerably enhanced as compared to freshly prepared liposomes. The skin permeation and localization properties of AsP in reconstituted liposomes were not significantly different, indicating that the liposomal structures were maintained before and after freezedrying. In conclusion, the freeze-drying method provided a possible way to overcome the instability issue of AsP induced by the moisture and reproduced similar skin permeation and localization properties as shown by freshly prepared liposomes.

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Stability of ascorbyl palmitate in topical microemulsions

Cited by 120 publications

References 6 publications

Preparation and Characterization of Water-in-Oil-in-Water Emulsions Containing a High Concentration ofL-Ascorbic Acid

Preparation and Characterization of Water-in-Oil-in-Water Emulsions Containing a High Concentration ofL-Ascorbic Acid

Enhancement of skin permeation of vitamin C using vibrating microneedles

Characterization and Evaluation of Freeze-dried Liposomes Loaded with Ascorbyl Palmitate Enabling Anti-aging Therapy of the Skin

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