Enhancement of skin permeation of vitamin C using vibrating microneedles

Abstract

This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC 0 -∞ and C max increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.

Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

“…Vibrating microneedles have been used to apply a 1.5% AA gel [ 109 ]. The vibrating microneedles enhanced the permeation of AA through the excised abdominal skin of the rat, in a manner dependent on the vibration intensity, application power, and AA gel application time [ 109 ].…”

“…Vibrating microneedles have been used to apply a 1.5% AA gel [ 109 ]. The vibrating microneedles enhanced the permeation of AA through the excised abdominal skin of the rat, in a manner dependent on the vibration intensity, application power, and AA gel application time [ 109 ]. Mesotherapy, a minimally invasive procedure involving a series of gentle, multiple micro-injections into the mesodermal layer under the skin, could be an additional option [ 110 , 111 ].…”

An evaluation of the antiaging properties of strawberry hydrolysate treatment enriched with L‐ascorbic acid applied with microneedle mesotherapy

“…Similarly, Badran et al found skin penetration and drug penetration to be enhanced by microneedling. In vitro and in vivo studies of vitamin C toxicity and efficiency administered in rats with vibrating microneedles (250 μm length) found a statistically significant increase in the permeability of active substances through the skin following treatment …”

Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats.

“…In a study investigating the in vitro and in vivo effectiveness of vibrating microneedles the on transdermal delivery of vitamin C, the microneedles were administered at three different intensity levels (level 1, 2 and 3), five different application times (1, 3, 5, 7, and 10 minutes) and three different application powers (500, 700 and 1000g). Obtained findings of both studies exhibited that vibrating microneedles significantly increased the permeability of Vitamin C from the skin resulting in enhanced AUC0-∞ and Cmax in rats [30]. Moreover, Liu et al performed a study to investigate the effect of vibration on transdermal delivery of insulin.…”