2013
DOI: 10.4172/2153-2435.1000233
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Stability Indicating Validated Chromatographic Methods for Determination of Buflomedil in Presence of its Degradation Products

Abstract: Simple, sensitive, selective and precise stability-indicating thin-layer chromatographic (TLC) andhigh-performance liquid chromatographic (HPLC) methodsfor the determination of Buflomedil (BFM) in pharmaceutical tablets were developed and validatedas per the International Conference on Harmonizationguidelines. The TLC method employs aluminum TLCplates precoated with silica gel 60F 254 as the stationary phase and Butanol: ammonia: triethylamine (8:0.5:0.5, v/v/v) as the mobile phase to give compact spots for Bu… Show more

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